Cytoskeletal alterations in human platelets exposed to oxidative stress are mediated by oxidative and Ca2+-dependent mechanisms

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides

1980 • 1,179 citations

The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.

1982 • 893 citations

Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes

1984 • 411 citations

Menadione-induced cytotoxicity is associated with protein thiol oxidation and alteration in intracellular Ca2+ homeostasis

1984 • 376 citations

Redox cycling and sulphydryl arylation; Their relative importance in the mechanism of quinone cytotoxicity to isolated hepatocytes

1988 • 296 citations

Ca2+-dependent protease in human platelets. Specific cleavage of platelet polypeptides in the presence of added Ca2+.

1977 • 274 citations

Metabolism and reactions of quinoid anticancer agents

1987 • 273 citations

Formation and reduction of glutathione-protein mixed disulfides during oxidative stress

1987 • 267 citations

Altered thiol and calcium homeostasis in oxidative hepatocellular injury

1985 • 249 citations

Cystamine induces toxicity in hepatocytes through the elevation of cytosolic Ca2+ and the stimulation of a nonlysosomal proteolytic system.

1986 • 249 citations

Identification of actin-binding protein as the protein linking the membrane skeleton to glycoproteins on platelet plasma membranes.

1985 • 236 citations

Identification of two proteins (actin-binding protein and P235) that are hydrolyzed by endogenous Ca2+-dependent protease during platelet aggregation.

1985 • 236 citations

Differential effects of phorbol ester on phenylephrine and vasopressin-induced Ca2+ mobilization in isolated hepatocytes.

1985 • 199 citations

Hepatic low-level chemiluminescence during redox cycling of menadione and the menadione-glutathione conjugate: Relation to glutathione and NAD(P)H:quinone reductase (DT-diaphorase) activity

1983 • 180 citations

Isolation and characterization of actin and actin-binding protein from human platelets.

1981 • 174 citations

Critical role of sulfhydryl group(s) in ATP‐dependent Ca²⁺ sequestration by the plasma membrane fraction from rat liver

1983 • 172 citations

Inhibition of hepatocyte plasma membrane Ca²⁺‐ATPase activity by menadione metabolism and its restoration by thiols

1985 • 168 citations

Calcium activated neutral protease: domain structure and activity regulation

1987 • 168 citations

Menadione-induced bleb formation in hepatocytes is associated with the oxidation of thiol groups in actin

1988 • 168 citations

Correlation between cytosolic Ca2+ concentration and cytotoxicity in hepatocytes exposed to oxidative stress

1988 • 139 citations

Actin filament content and organization in unstimulated platelets.

1984 • 112 citations

Characterization of platelet extracts before and after stimulation with respect to the possible role of profilactin as microfilament precursor

1981 • 100 citations

Isolation of brain .alpha.-actinin. Its characterization and a comparison of its properties with those of muscle .alpha.-actinins

1984 • 95 citations

Isolation and characterization of a calcium-sensitive alpha-actinin-like protein from human platelet cytoskeletons.

1981 • 95 citations

Purification of human platelet calcium-activated protease. Effect on platelet and endothelial function.

1983 • 95 citations

The effect of mild diamide oxidation on the structure and function of human erythrocyte spectrin.

1986 • 94 citations

Alterations of surface morphology caused by the metabolism of menadione in mammalian cells are associated with the oxidation of critical sulfhydryl groups in cytoskeletal proteins

1988 • 83 citations

Hydrogen peroxide lowers ATP levels in platelets without altering adenyalte energy charge and platelet function.

1977 • 82 citations

Protein 4.1 in sickle erythrocytes. Evidence for oxidative damage.

1987 • 76 citations

Cytoskeletal reorganization of human platelets after stimulation revealed by the quick-freeze deep-etch technique.

1987 • 69 citations

Organization of the actin cytoskeleton of resting and activated platelets in suspension.

1986 • 67 citations

The high affinity (Ca2+-Mg2+)-ATPase in liver plasma membranes is a Ca2+ pump. Reconstitution of the purified enzyme into phospholipid vesicles.

1987 • 46 citations

Reversed‐phase high‐performance liquid chromatographic analysis of endogenous purine ribonucleotide pools in BHK monolayer cultures

1983 • 22 citations

Association of actin with the platelet membrane

1984 • 18 citations

Platelet cytoskeleton — Membrane interactions

1985 • 3 citations