Chemical carcinogenesis: too many rodent carcinogens.

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1983 • 3,602 citations

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

Allelotype of Colorectal Carcinomas

1989 • 1,333 citations

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

1990 • 1,100 citations

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.

1989 • 961 citations

Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis

1990 • 741 citations

Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U.S. NCI/NTP

1988 • 736 citations

Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.

1989 • 733 citations

Endogenous Oxidative DNA Damage, Aging, and Cancer

1989 • 711 citations

Estrogens as a cause of human cancer: the Richard and Hinda Rosenthal Foundation award lecture.

1988 • 703 citations

Diet, nutrition, and cancer

1976 • 678 citations

Ranking Possible Carcinogenic Hazards

1987 • 570 citations

Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1.

1986 • 519 citations

Genomic 5-methyldeoxycytidine decreases with age.

1987 • 504 citations

A carcinogenic potency database of the standardized results of animal bioassays

1984 • 471 citations

T Cells Responsive to Myelin Basic Protein in Patients with Multiple Sclerosis

1990 • 447 citations

Dietary pesticides (99.99% all natural).

1990 • 400 citations

Biomarkers of increased susceptibility to gastrointestinal cancer: new application to studies of cancer prevention in human subjects.

1988 • 380 citations

Cellular biochemistry of the stepwise development of cancer with chemicals: G. H. A. Clowes memorial lecture.

1984 • 363 citations

Genetic Origin of Mutations Predisposing to Retinoblastoma

1985 • 363 citations

Gap junctional communication and carcinogenesis

1990 • 310 citations

Campylobacter pylori and gastroduodenal disease

1990 • 303 citations

Human Lymphocytes Exposed to Low Doses of Ionizing Radiations Become Refractory to High Doses of Radiation as Well as to Chemical Mutagens that Induce Double-strand Breaks in DNA

1988 • 283 citations

Carcinogenicity of mutagens: predictive capability of the Salmonella mutagenesis assay for rodent carcinogenicity.

1987 • 275 citations

Mutagenesis and carcinogenesis: Endogenous and exogenous factors

1989 • 266 citations

Inhibition of dietary fat-promoted colon carcinogenesis in rats by supplemental calcium or vitamin D₃

1988 • 215 citations

Anticarcinogenesis and Radiation Protection

1987 • 210 citations

Genetics of cancer predisposition.

1987 • 199 citations

Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation and reactive oxygen formation by bile acids.

1987 • 199 citations

Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice.

1990 • 199 citations

A method to quantitate the relative initiating and promoting potencies of hepatocarcinogenic agents in their dose-response relationships to altered hepatic foci

1987 • 197 citations

Diet, Nutrition, and Cancer A Critical Evaluation

1985 • 189 citations

Measurement of unscheduled DNA synthesis and S‐phase synthesis in rodent hepatocytes following in vivo treatment: Testing of 24 compounds

1989 • 188 citations

The resistance of putative premalignant liver cell populations, hyperplastic nodules, to the acute cytotoxic effects of some hepatocarcinogens.

1976 • 188 citations

Induction of Cytogenetic Adaptive Response of Somatic and Germ Cellsin Vivoandin Vitroby Low-dose X-irradiation

1990 • 186 citations

Clonal adaptation during carcinogenesis

1990 • 180 citations

Chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1982.

1986 • 166 citations

Inhibition of Lung Injury, Inflammation, and Interstitial Pulmonary Fibrosis by Polyethylene Glycol-conjugated Catalase in a Rapid Inhalation Model of Asbestosis

1990 • 165 citations

Third chronological supplement to the carcinogenic potency database: standardized results of animal bioassays published through December 1986 and by the National Toxicology Program through June 1987.

1990 • 147 citations

Oncogenes and the molecular origins of cancer

1991 • 142 citations

The impact of toxicity on carcinogenicity studies: implications for risk assessment

1988 • 134 citations

Summary of carcinogenic potency and positivity for 492 rodent carcinogens in the carcinogenic potency database.

1989 • 133 citations

Carcinogens induce intrachromosomal recombination in yeast

1989 • 129 citations

Some tautologous aspects of the comparison of carcinogenic potency in rats and mice

1985 • 126 citations

Interspecies extrapolation in carcinogenesis: prediction between rats and mice.

1989 • 124 citations

Evidence for intrachromosomal gene conversion in cultured mouse cells

1983 • 124 citations

Chromosomal Aberrations: Basic and Applied Aspects

2011 • 118 citations

Issues in carcinogenicity testing: Dose selection

1985 • 111 citations

Diet and human carcinogenesis

1987 • 109 citations

Stomach Cancer and Food Storage

1989 • 108 citations

NaCl induced ornithine decarboxylase and DNA synthesis in rat stomach mucosa

1984 • 104 citations

Molecular evidence that homologous recombination occurs in proliferating human somatic cells.

1990 • 93 citations

Primary hepatocellular carcinoma and hepatitis B infection during childhood

1987 • 93 citations

Cell proliferation and promotion of rat liver carcinogenesis: different effect of hepatic regeneration and mitogen induced hyperplasia on the development of enzyme-altered foci

1990 • 87 citations

Diet and carcinogenesis

1981 • 86 citations

Flow cytometric analysis of the effect of sodium chloride on gastric cancer risk in the rat.

1985 • 85 citations

High- to low-dose extrapolation: critical determinants involved in the dose response of carcinogenic substances.

1987 • 85 citations

Loss of constitutional heterozygosity in colorectal tumors from patients with familial polyposis coli and those with nonpolyposis colorectal carcinoma.

1989 • 81 citations

Inflammation, oxidative DNA damage, and carcinogenesis.

1987 • 78 citations

Molecular analyses of in vivo hprt mutations in human T-lymphocytes III. Longitudinal study of hprt gene structural alterations and T-cell clonal origins

1989 • 76 citations

Drosophila Chorion Gene Amplification Requires an Upstream Region Regulating s18 Transcription

1986 • 72 citations

Salt and gastrointestinal cancer

1988 • 71 citations

Cell cycle-specific mutagenesis at the hypoxanthine phosphoribosyltransferase locus in adult rat liver epithelial cells.

1980 • 67 citations

Theories of Carcinogenesis

2007 • 64 citations

Molecular analyses of in vivo hypoxanthine‐guanine phosphoribosyltransferase mutations in human T‐lymphocytes: II. Demonstration of a clonal amplification of hprt mutant T‐lymphocytes in vivo

1988 • 64 citations

Mutations in human lymphocytes commonly involve gene duplication and resemble those seen in cancer cels.

1988 • 62 citations

Evaluation of the cocarcinogenic effect of wounding in Rous sarcoma virus tumorigenesis.

1989 • 57 citations

Stimulation of tyrosine-specific protein phosphorylation in the rat liver plasma membrane by oxygen radicals

1986 • 57 citations

Ranking the potential carcinogenic hazards to workers from exposures to chemicals that are tumorigenic in rodents.

1987 • 52 citations

Campylobacter pylori in Gastritis and Peptic Ulcer Disease

1990 • 52 citations

Evidence that the familial adenomatous polyposis gene is involved in a subset of colon cancers with a complementable defect in c-myc regulation.

1989 • 50 citations

Age-Related Factors in Carcinogenesis

1986 • 45 citations

Effect of Dose Rate on the Induction of Experimental Lung Cancer in Hamsters by α Radiation

1985 • 40 citations

Short-term testing — are we looking at wrong endpoints?

1988 • 39 citations

Dose response of hepatocyte replication in rats following continuous exposure to diethylnitrosamine.

1989 • 37 citations

Correlation between High Salt Intake and Mortality Rates for Oesophageal and Gastric Cancers in Henan Province, China

1987 • 35 citations

Possible Etiologic Mechanisms in Chemical Carcinogenesis

1987 • 33 citations

Liver hyperplasia is not necessarily associated with increased expression of c-fos and c-myc mRNA

1990 • 31 citations

A serological case-control study of primary hepatocellular carcinoma in Guangxi, China.

1985 • 30 citations

Calcium chloride inhibits stimulation of replicative DNA synthesis by sodium chloride in the pyloric mucosa of rat stomach

1989 • 26 citations

The role of micronutrient deficiency in carcinogenesis

1987 • 25 citations

A Unifying Concept for Carcinogenic Risk Assessments

1984 • 22 citations

The effect of dose and time on the induction of genetic alterations insaccharomyces cerevisiae by aminoacridines in the presence and absence of visible light irradiation in comparison with the dose-effect-curves of mutagens with other type of action

1976 • 20 citations

Squamous-cell carcinoma and oral, pharyngeal and nasal lesions caused by foreign bodies in feed. Cases from a long-term study in rats

1989 • 20 citations

Cell Differentiation, Genes and Cancer

1989 • 17 citations

Campylobacter pylori and gastroduodenal disease.

1989 • 14 citations

Hypomethylation of DNA in estrogen-induced and -dependent hamster kidney tumors

1988 • 13 citations

Induction of Squamous Metaplasia, Dysplasia and Carcinoma in situ of the Mouse Tracheal Mucosa by Inhalation of Sodium Chloride Mist Following Subcutaneous Injection of 4‐Nitroquinoline 1‐Oxide

1989 • 12 citations

Pre-existing, non-malignant disorders associated with increased cancer risk.

1980 • 9 citations

Issues of biochemical applications to risk assessment: how should the MTD be selected for chronic bioassays?

1987 • 7 citations

Diet, Nutrition, and Cancer: A Critical Evaluation

2018 • 4 citations