Ageing of Neurospora crassa. I. Evidence for the free radical theory of ageing from studies of a natural-death mutant

Superoxide Dismutase

1969 • 12,578 citations

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Superoxide Dismutases

1975 • 1,673 citations

THE MAINTENANCE OF THE ACCURACY OF PROTEIN SYNTHESIS AND ITS RELEVANCE TO AGEING

1963 • 950 citations

Lipid peroxidation damage to cell components.

1973 • 925 citations

NEUROSPORA. II. METHODS OF PRODUCING AND DETECTING MUTATIONS CONCERNED WITH NUTRITIONAL REQUIREMENTS

1945 • 533 citations

On the Reaction Mechanism of Yeast Glutathione Reductase

1965 • 484 citations

Ageing of Clones of Mammalian Cells

1973 • 409 citations

THE TUBE METHOD OF MEASURING THE GROWTH RATE OF NEUROSPORA

1943 • 374 citations

Free Radical Theory of Aging: Effect of Free Radical Reaction Inhibitors on the Mortality Rate of Male LAF1 Mice

1968 • 339 citations

Rate And Magnitude Of Age Pigment Accumulation In The Human Myocardium

1959 • 336 citations

The purification and properties of Neurospora malate dehydrogenase

1965 • 238 citations

Membrane Stabilization by Drugs: Tranquilizers, Steroids, and Anesthetics

1966 • 234 citations

SUPEROXIDE DISMUTASE, CATALASE AND GLUTATHIONE PEROXIDASE: SOLUTIONS TO THE PROBLEMS OF LIVING WITH OXYGEN

1974 • 224 citations

Effect of Antioxidants and Nutrients on Lipid Peroxidation Fluorescent Products and Aging Parameters in the Mouse

1973 • 224 citations

Neurospora. II. Methods of Producing and Detecting Mutations Concerned with Nutritional Requirements

1945 • 216 citations

Response of Glutathione Peroxidase to Dietary Selenium in Rats

1974 • 196 citations

Selenium in Biology

1975 • 192 citations

Lipofuscin Pigment Accumulation and Distribution in Five Rat Organs as a Function of Age

1968 • 132 citations

Effect of Ethoxyquin on the Longevity of C3H Mice

1971 • 129 citations

Free radical reactions and their importance in biochemical systems.

1973 • 129 citations

The Purification and Properties of Superoxide Dismutase from Neurospora crassa

1972 • 129 citations

The Tube Method of Measuring the Growth Rate of Neurospora

1943 • 120 citations

Lipid oxidation in biological membranes

1970 • 117 citations

Effect of Antioxidants on Life-Span of C57BL Mice

1971 • 109 citations

Errors in Protein Synthesis and Clonal Senescence in Fungi

1969 • 104 citations

Mistranslation and Ageing in Neurospora

1970 • 98 citations

Selenium and Tellurium in Rats: Effect on Growth, Survival and Tumors

1971 • 97 citations

Extension of the Lifespan of Cultured Normal Human Diploid Cells by Vitamin E

1974 • 96 citations

Lysosomal enzymes and aging in vitro: Subcellular enzyme distribution and effect of hydrocortisone on cell life-span☆

1975 • 92 citations

Studies on ageing in nematodes III. Electronmicroscopical studies on age-associated cellular damage

1972 • 85 citations

Studies on ageing in nematodes IV. The effect of anti-oxidants on cellular damage and life span

1972 • 81 citations

Genetically determined multiple forms of glutamic dehydrogenase in Neurospora crassa

1962 • 79 citations

The Maintenance of the Accuracy of Protein Synthesis and Its Relevance to Aging

2001 • 67 citations

Fluorescent Products and Lysosomal Components in Aging Drosophila melanogaster

1974 • 65 citations

Purification of Superoxide Dismutase From Fungi and Characterization of the Reaction of the Enzyme with Catechols by Electron Spin Resonance Spectroscopy

1973 • 55 citations

Age dependent changes in enzymes involved in macromolecular synthesis in Turbatrix aceti

1975 • 53 citations

The position of aging studies

1974 • 47 citations

A GENE THAT CAUSES NATURAL DEATH IN NEUROSPORA CRASSA

1951 • 39 citations

Autofluorescent structures in cultured WI-38 cells

1974 • 39 citations

Effect of membrane stabilizing drugs on mortality in Drosophila melanogaster

1971 • 38 citations

Purification and Partial Characterization of Glucose 6-Phosphate Dehydrogenase from Neurospora crassa

1971 • 35 citations

New Evidence Concerning Mechanisms of Action of Vitamin E and Selenium

1975 • 29 citations

Ageing of Neurospora crassa. IV. Induction of senescence in wild type by dietary amino acid analogs and reversal by antioxidants and membrane stabilizers

1976 • 28 citations

Preparation of mitochondrial membrane proteins fromNeurospora crassa: prevention of lipid autoxidation damage by an antioxidant

1973 • 27 citations

Tocopherol, Ubiquinones and Ubichromenols in Yeasts and Mushrooms

1961 • 26 citations

A REGULATORY SYSTEM CONTROLLING INHIBITION IN THE SEXUAL CYCLE OFNEUROSPORA

1969 • 21 citations

Ageing of Neurospora crassa. II. Organic hydroperoxide toxicity and the protective role of antioxidant and the antioxygenic enzymes

1976 • 21 citations

Ageing of Neurospora crassa. III. Induction of cellular death and clonal senescence of an inositol-less mutant by inositol starvation and the protective effect of dietary antioxidants

1976 • 16 citations

The effect of the administration of compounds which contain sulfhydryl groups on the survival rates of mice, rats, and guinea pigs.

1965 • 12 citations

Procedure for measurement of logarithmic growth

1973 • 2 citations