Strategies for expressing human antibody repertoires in transgenic mice

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

Making Antibodies by Phage Display Technology

1994 • 1,516 citations

The human immunoglobulin VH repertoire

1995 • 469 citations

Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the J_H locus

1993 • 404 citations

Antigen-specific human antibodies from mice comprising four distinct genetic modifications

1994 • 382 citations

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1994 • 382 citations

Antigen–specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs

1994 • 351 citations

Structure and physical map of 64 variable segments in the 3′ 0.8–megabase region of the human immunoglobulin heavy–chain locus

1993 • 332 citations

Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation

1993 • 283 citations

Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells.

1994 • 258 citations

Somatic hypermutation

1995 • 248 citations

A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q

1994 • 243 citations

A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus

1990 • 220 citations

Germ-line transmission and expression of a human-derived yeast artificial chromosome

1993 • 155 citations

Organization of the human immunoglobulin lambda light-chain locus on chromosome 22q11.2

1995 • 139 citations

A method for the generation of YAC transgenic mice by pronuclear microinjection

1993 • 130 citations

Construction of a Panel of Transgenic Mice Containing a Contiguous 2-Mb Set of YAC/P1 Clones from Human Chromosome 21q22.2

1995 • 104 citations

Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies

1994 • 101 citations

The Immunoglobulin Heavy Chain Locus Contains Another B-Cell-Specific 3' Enhancer Close to the α Constant Region

1993 • 92 citations

Transgenic mice containing a human heavy chain immunoglobulin gene fragment cloned in a yeast artificial chromosome

1993 • 87 citations

A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulins

1992 • 82 citations

Human antibody production in transgenic mice: expression from 100 kb of the human IgH locus

1991 • 82 citations

The immunoglobulin κ locus — or — what has been learned from looking closely at one-tenth of a percent of the human genome

1993 • 81 citations

Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM

1994 • 74 citations

Somatic hypermutation of an immunoglobulin mu heavy chain transgene.

1993 • 69 citations

Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation.

1993 • 62 citations

YAC transgenics and the study of genetics and human disease

1995 • 57 citations

The immunoglobulin heavy chain locus contains another B-cell-specific 3' enhancer close to the alpha constant region.

1993 • 50 citations

Generation of a mouse strain that produces immunoglobulin kappa chains with human constant regions

1993 • 48 citations

Creation of Mice Expressing Human Antibody Light Chains by Introduction of a Yeast Artificial Chromosome Containing the Core Region of the Human Immunoglobulin κ Locus

1993 • 45 citations

The diversity of antigen‐specific monoclonal antibodies from transgenic mice bearing human immunoglobulin gene miniloci

1994 • 44 citations

Targeted alterations in yeast artificial chromosomes for inter-species gene transfer

1992 • 35 citations

Antibodies generated from human immunoglobulin miniloci in transgenic mice

1994 • 32 citations

Tools of the Trade YAC Vectors: Humanizing the mouse genome

1994 • 14 citations

Extension of yeast artificial chromosomes by cosmid multimers

1993 • 7 citations