A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulins

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

A simple and very efficient method for generating cDNA libraries

1983 • 4,606 citations

Ras C-terminal processing enzymes—New drug targets?

1991 • 461 citations

Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences.

1990 • 414 citations

Regulation of the Assembly and Expression of Variable-Region Genes

1986 • 402 citations

Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes.

1991 • 364 citations

Organization of human immunoglobulin heavy chain diversity gene loci.

1988 • 317 citations

Allelic Exclusion in Transgenic Mice That Express the Membrane form of Immunoglobulin μ

1987 • 293 citations

Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions.

1991 • 276 citations

Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life.

1990 • 252 citations

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.

1990 • 224 citations

A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus

1990 • 220 citations

Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family‐specific oligonucleotide probes

1991 • 215 citations

The B-cell antigen receptor complex

1991 • 213 citations

A new human immunoglobulin VH family preferentially rearranged in immature B-cell tumours

1988 • 174 citations

Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints.

1988 • 174 citations

A conserved human germline V kappa gene directly encodes rheumatoid factor light chains.

1986 • 166 citations

A repertoire of monoclonal antibodies with human heavy chains from transgenic mice.

1989 • 145 citations

Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains.

1988 • 138 citations

Synthetic sites for transcription termination and a functional comparison with tryptophan operon termination sites in vitro.

1981 • 110 citations

The human VK locus

1988 • 90 citations

Human antibody production in transgenic mice: expression from 100 kb of the human IgH locus

1991 • 82 citations

The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line.

1992 • 82 citations

Lack of feedback inhibition of V kappa gene rearrangement by productively rearranged alleles.

1991 • 80 citations

Production of sterile transcripts of C_γ genes in an IgM-producing human neoplastic B cell line that switches to IgG-producing cells

1989 • 74 citations

The V_ϰ gene repertoire in the human germ line

1990 • 70 citations

The recurrent expression of variable region segments in human IgM anti-DNA autoantibodies.

1989 • 68 citations

Rearrangement of a chicken immunoglobulin gene occurs in the lymphoid lineage of transgenic mice

1987 • 64 citations

Rearrangement and expression of rabbit immunoglobulin kappa light chain gene in transgenic mice.

1987 • 49 citations

Immunoglobulin D switching can occur through homologous recombination in human B cells.

1990 • 45 citations

Class switch from μ to δ is mediated by homologous recombination between σ_μ and σ_μ sequences in human immunoglobulin gene loci

1989 • 44 citations

Allelic exclusion in transgenic mice carrying mutant human IgM genes.

1988 • 42 citations

Amino acids at the site of V kappa-J kappa recombination not encoded by germline sequences.

1987 • 39 citations

Immunoglobulin x light chain gene promoter and enhancer are not responsible for B-cell restricted gene rearrangement

1989 • 28 citations

Immunoglobulin D Switching Can Occur through Homologous Recombination in Human Β Cells

1990 • 14 citations