Generation of a mouse strain that produces immunoglobulin kappa chains with human constant regions

Reshaping human antibodies for therapy

1988 • 1,555 citations

Replacing the complementarity-determining regions in a human antibody with those from a mouse

1986 • 1,356 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains.

1984 • 1,002 citations

The somatic generation of immune recognition

1971 • 974 citations

Maturation of the immune response in germinal centers

1991 • 904 citations

Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage Lambda

1989 • 810 citations

A humanized antibody that binds to the interleukin 2 receptor.

1989 • 624 citations

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

1984 • 534 citations

Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments

1980 • 402 citations

Reshaping Human Antibodies: Grafting an Antilysozyme Activity

1988 • 348 citations

Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation.

1982 • 320 citations

A hapten-specific chimaeric IgE antibody with human physiological effector function

1985 • 289 citations

Relationship of germinal centers in lymphoid tissue to immunologic memory. VI. Transfer of B cell memory with lymph node cells fractionated according to their receptors for peanut agglutinin.

1983 • 274 citations

Stable Expression and Somatic Hypermutation of Antibody V Regions in B-Cell Developmental Pathways

1989 • 271 citations

Genetics, Expression, and Function of Idiotypes

1983 • 264 citations

Peanut lectin binding properties of germinal centers of mouse lymphoid tissue

1980 • 259 citations

The immunogenicity of chimeric antibodies.

1989 • 176 citations

Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappa.

1993 • 160 citations

Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse

1989 • 157 citations

A repertoire of monoclonal antibodies with human heavy chains from transgenic mice.

1989 • 145 citations

Engraftment and Development of Human T and B Cells in Mice After Bone Marrow Transplantation

1991 • 100 citations

Somatic mutations in antibodies expressed by germinal centre B cells early after primary immunization

1990 • 83 citations

A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulins

1992 • 82 citations

Human antibody production in transgenic mice: expression from 100 kb of the human IgH locus

1991 • 82 citations

[12] The EBV-hybridoma technique

1986 • 45 citations

Phage Display Technology in Antibody Engineering: Design of Phagemid Vectors and in vitro Maturation Systems

1992 • 44 citations

Production of human antibodies using bacteriophage

1993 • 43 citations

Immunoglobulin genes of thexlight chain type from two human lymphoid cell lines are closely related

1984 • 39 citations

V genes of the primary antibody response of C57BL110 mice to the hapten phenyloxazolone

1988 • 22 citations

Ruggero Ceppellini (1917–1988)

1988 • 5 citations