Transgenic mice containing a human heavy chain immunoglobulin gene fragment cloned in a yeast artificial chromosome

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

1990 • 1,531 citations

Cloning of Large Segments of Exogenous DNA into Yeast by Means of Artificial Chromosome Vectors

1987 • 1,517 citations

Simplified mammalian DNA isolation procedure

1991 • 1,508 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Teratocarcinomas and embryonic stem cells : a practical approach

1987 • 878 citations

Teratocarcinomas and embryonic stem cells: A practical approach

1987 • 768 citations

Introns increase transcriptional efficiency in transgenic mice.

1988 • 733 citations

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

1985 • 710 citations

Guide to Yeast Genetics and Molecular Biology

1991 • 607 citations

Selection of phage antibodies by binding affinity

1992 • 514 citations

Transgenic Animals

1988 • 473 citations

Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus.

1988 • 432 citations

Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the J_H locus

1993 • 404 citations

Organization of human immunoglobulin heavy chain diversity gene loci.

1988 • 317 citations

A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice

1993 • 275 citations

[10] Analysis and manipulation of yeast mitochondrial genes

1991 • 256 citations

Genomic DNA microextraction: A method to screen numerous samples

1992 • 221 citations

Germ-line transmission and expression of a human-derived yeast artificial chromosome

1993 • 155 citations

Efficient transformation of mammalian cells with constructs containing a puromycin-resistance marker

1988 • 146 citations

Structural instability of human tandemly repeated DNA sequences cloned in yeast artificial chromosome vectors

1990 • 139 citations

Physical map of the 3′ region of the human immunoglobulin heavy chain locus: clustering of autoantibody-related variable segments in one haplotype.

1991 • 115 citations

Complete physical map of the human immunoglobulin heavy chain constant region gene complex.

1989 • 109 citations

Engraftment and Development of Human T and B Cells in Mice After Bone Marrow Transplantation

1991 • 100 citations

Modification and transfer into an embryonal carcinoma cell line of a 360-kilobase human-derived yeast artificial chromosome.

1990 • 91 citations

Transfer of a yeast artificial chromosome carrying human DNA from Saccharomyces cerevisiae into mammalian cells.

1990 • 90 citations

Transgenic mice generated by pronuclear injection of a yeast artificial chromosome

1992 • 88 citations

The human HPRT gene on a yeast artificial chromosome is functional when transferred to mouse cells by cell fusion

1991 • 84 citations

Dispersed localization of D segments in the human immunoglobulin heavy-chain locus.

1988 • 81 citations

Rapid screening of a human genomic library in yeast artificial chromosomes for single-copy sequences.

1989 • 74 citations

Amplification of large artificial chromosomes.

1990 • 72 citations

XIST and the mapping of the X chromosome inactivation centre

1991 • 69 citations

V_H gene usage in humans: biased usage of the V_H6 gene in immature B lymphoid cells

1991 • 60 citations

Cloning and in vivo expression of the human GART gene using yeast artificial chromosomes.

1991 • 58 citations

The human immunoglobulin C_μ–C_δlocus: complete nucleotide sequence and structural analysis

1989 • 45 citations

Molecular complementation of a collagen mutation in mammalian cells using yeast artificial chromosomes.

1992 • 43 citations

Stable integration and expression in mouse cells of yeast artificial chromosomes harboring human genes.

1991 • 36 citations

Targeted alterations in yeast artificial chromosomes for inter-species gene transfer

1992 • 35 citations

Transfer of the human HPRT and GART genes from yeast to mammalian cells by microinjection of YAC DNA

1991 • 21 citations

Targeted integration of neomycin into yeast artificial chromosomes (YACs) for transfection into mammalian cells

1992 • 21 citations

Developmental Regulation of Secreted and Membrane Forms of Immunoglobulin μ Chain

1989 • 16 citations

A strategy for rapid production and screening of yeast artificial chromosome libraries

1992 • 10 citations

Integrative selection of human chromosome-specific yeast artificial chromosomes.

1991 • 9 citations