PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Small GTP-Binding Proteins

2001 • 2,449 citations

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1997 • 1,190 citations

Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)

1999 • 1,084 citations

Direct control of the Forkhead transcription factor AFX by protein kinase B

1999 • 1,080 citations

The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function

1999 • 1,007 citations

The structural basis of the activation of Ras by Sos

1998 • 765 citations

Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt

1999 • 762 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Regulation of protein kinase C ζ by PI 3-kinase and PDK-1

1998 • 612 citations

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.

1996 • 568 citations

Small GTP-Binding Proteins

1992 • 526 citations

The small GTPase RalA targets filamin to induce filopodia

1999 • 449 citations

Cellular Signaling

2000 • 415 citations

Multiple Ras Effector Pathways Contribute to G1Cell Cycle Progression

1999 • 414 citations

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

1992 • 361 citations

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.

1996 • 335 citations

Bridging Ral GTPase to Rho Pathways

1995 • 330 citations

Identification and Characterization of Ral-Binding Protein 1, a Potential Downstream Target of Ral GTPases

1995 • 304 citations

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.

1994 • 270 citations

Involvement of Ral GTPase in v-Src-induced phospholipase D activation

1995 • 261 citations

Isotype-Specific Functions of Raf Kinases

1999 • 259 citations

A Role for the Ral Guanine Nucleotide Dissociation Stimulator in Mediating Ras-induced Transformation

1996 • 245 citations

Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors

1999 • 232 citations

Evidence for a Ras/Ral signaling cascade

1996 • 214 citations

RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis

2000 • 179 citations

A putative effector of Ral has homology to Rho/Rac GTPase activating proteins.

1995 • 176 citations

Stimulation of gene induction and cell growth by the Ras effector Rlf

1997 • 167 citations

Identification and Characterization of a Novel Protein Interacting with Ral-binding Protein 1, a Putative Effector Protein of Ral

1998 • 143 citations

An Eps Homology (EH) Domain Protein That Binds to the Ral-GTPase Target, RalBP1

1997 • 128 citations

An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity

2000 • 125 citations

Discovery of PDKI, One of the Missing Links in Insulin Signal Transduction

2001 • 125 citations

RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein.

1996 • 121 citations

Ras-dependent activation of the small GTPase Ral

1998 • 112 citations

Ral GTPases Contribute to Regulation of Cyclin D1 through Activation of NF-κB

2000 • 105 citations

Phospholipase D and RalA Cooperate with the Epidermal Growth Factor Receptor To Transform 3Y1 Rat Fibroblasts

2000 • 100 citations

p130Cas Regulates the Activity of AND-34, a Novel Ral, Rap1, and R-Ras Guanine Nucleotide Exchange Factor

2000 • 97 citations

Plasma membrane recruitment of RalGDS is critical for Ras-dependent Ral activation

1999 • 89 citations

Ral-GTPase Influences the Regulation of the Readily Releasable Pool of Synaptic Vesicles

2002 • 83 citations

Discovery of PDK1, One of the Missing Links in Insulin Signal Transduction

2001 • 80 citations

Ras-independent activation of Ral by a Ca2+-dependent pathway

1998 • 79 citations

Ras-Dependent Regulation of c-Jun Phosphorylation Is Mediated by the Ral Guanine Nucleotide Exchange Factor-Ral Pathway

2000 • 78 citations

Identification and Characterization of a New Family of Guanine Nucleotide Exchange Factors for the Ras-related GTPase Ral

2000 • 77 citations

Colocalization of Ras and Ral on the membrane is required for Ras-dependent Ral activation through Ral GDP dissociation stimulator

1997 • 67 citations

Regulation of Ras Signaling Specificity by Protein Kinase C

2001 • 63 citations

Prenylation of Target GTPases Contributes to Signaling Specificity of Ras-Guanine Nucleotide Exchange Factors

2001 • 31 citations