Antimicrobial peptides in innate immunity of the human intestine

Innate Immune Recognition

2002 • 8,157 citations

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

2001 • 4,997 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Toll-like receptors and innate immunity

2001 • 4,138 citations

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

1999 • 3,351 citations

Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides

2001 • 2,867 citations

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

2002 • 2,438 citations

MICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT

1977 • 2,394 citations

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

2000 • 2,076 citations

Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction

1999 • 1,905 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6

1999 • 1,760 citations

A family of human receptors structurally related to Drosophila Toll

1998 • 1,735 citations

The leucine-rich repeat as a protein recognition motif

2001 • 1,584 citations

Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double-blind, placebo-controlled trial

2000 • 1,505 citations

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

2001 • 1,498 citations

Defensins. Natural peptide antibiotics of human neutrophils.

1985 • 1,411 citations

Mucosal flora in inflammatory bowel disease

2002 • 1,344 citations

Cationic peptides: a new source of antibiotics

1998 • 1,322 citations

Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression

2001 • 1,305 citations

Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease

2000 • 1,246 citations

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

1998 • 1,218 citations

A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.

1995 • 1,205 citations

Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

2001 • 1,096 citations

The Toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

1988 • 1,077 citations

Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

1995 • 965 citations

TIRAP: an adapter molecule in the Toll signaling pathway

2001 • 962 citations

Microbial modulation of innate defense: goblet cells and the intestinal mucus layer

2001 • 959 citations

Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by β-Defensin 2

2002 • 885 citations

Lipopolysaccharide Activates Distinct Signaling Pathways in Intestinal Epithelial Cell Lines Expressing Toll-Like Receptors

2000 • 754 citations

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

1993 • 732 citations

Induction of Direct Antimicrobial Activity Through Mammalian Toll-Like Receptors

2001 • 709 citations

A Cyclic Antimicrobial Peptide Produced in Primate Leukocytes by the Ligation of Two Truncated α-Defensins

1999 • 686 citations

Defensins of vertebrate animals

2002 • 659 citations

Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium.

1999 • 602 citations

Production of β-defensins by human airway epithelia

1998 • 574 citations

Double blind, placebo controlled trial of metronidazole in Crohn's disease.

1991 • 543 citations

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

2000 • 538 citations

Inhibition of Lipopolysaccharide-Induced Signal Transduction in Endotoxin-Tolerized Mouse Macrophages: Dysregulation of Cytokine, Chemokine, and Toll-Like Receptor 2 and 4 Gene Expression

2000 • 517 citations

FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis.

1995 • 499 citations

Bacterial strategies for overcoming host innate and adaptive immune responses

2002 • 476 citations

Lipopolysaccharide Rapidly Traffics to and from the Golgi Apparatus with the Toll-like Receptor 4-MD-2-CD14 Complex in a Process That Is Distinct from the Initiation of Signal Transduction

2002 • 452 citations

Downregulation of bactericidal peptides in enteric infections: A novel immune escape mechanism with bacterial DNA as a potential regulator

2001 • 425 citations

Toll-like Receptor 4 Resides in the Golgi Apparatus and Colocalizes with Internalized Lipopolysaccharide in Intestinal Epithelial Cells

2002 • 414 citations

Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: a cohort study

2002 • 413 citations

Toll-related receptors and the control of antimicrobial peptide expression inDrosophila

2000 • 380 citations

Antimicrobial peptides of vertebrates

1998 • 377 citations

Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites

1997 • 373 citations

Microbial Lipopeptides Stimulate Dendritic Cell Maturation Via Toll-Like Receptor 2

2001 • 360 citations

Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin‐10 or antibodies to interleukin‐12

1996 • 358 citations

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

1999 • 336 citations

NF-kappa B is a central regulator of the intestinal epithelial cell innate immune response induced by infection with enteroinvasive bacteria.

1999 • 334 citations

Cathelicidins: a family of endogenous antimicrobial peptides

2002 • 318 citations

CD14-dependent Lipopolysaccharide-induced β-Defensin-2 Expression in Human Tracheobronchial Epithelium

2000 • 309 citations

Commensal-Associated Molecular Patterns Induce Selective Toll-Like Receptor-Trafficking from Apical Membrane to Cytoplasmic Compartments in Polarized Intestinal Epithelium

2002 • 306 citations

Development of chronic colitis is dependent on the cytokine MIF

2001 • 305 citations

Apoptosis of human intestinal epithelial cells after bacterial invasion.

1998 • 302 citations

Human Enteric Defensins

1996 • 301 citations

Participation of mammalian defensins and cathelicidins in anti-microbial immunity: receptors and activities of human defensins and cathelicidin (LL-37)

2001 • 274 citations

Activation of NF-κB in intestinal epithelial cells by enteropathogenic Escherichia coli

1997 • 258 citations

Structural features and biological activities of the cathelicidin‐derived antimicrobial peptides

2000 • 257 citations

Innate mechanisms of epithelial host defense: spotlight on intestine

1999 • 233 citations

Long-term treatment of ulcerative colitis with ciprofloxacin: A prospective, double-blind, placebo-controlled study

1998 • 232 citations

Cell length, cell growth and cell division

1976 • 229 citations

Broad-spectrum antimicrobial activity of human intestinal defensin 5

1997 • 228 citations

Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease

2001 • 217 citations

Effect of defensins on interleukin-8 synthesis in airway epithelial cells

1997 • 203 citations

Human β-defensin 2 but not β-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel disease

2002 • 201 citations

Localization of human intestinal defensin 5 in Paneth cell granules

1997 • 188 citations

Defensins and innate host defence of the gastrointestinal tract

1999 • 177 citations

Differential cytokine regulation of complement C3, C4, and factor B synthesis in human intestinal epithelial cell line, Caco-2.

1993 • 141 citations

Paneth Cell Defensins and Innate Immunity of the Small Bowel

2001 • 141 citations

Probiotics in infective diarrhoea and inflammatory bowel diseases

2000 • 140 citations

Salmonella enteritidis FliC (Flagella Filament Protein) Induces Human β-Defensin-2 mRNA Production by Caco-2 Cells

2001 • 139 citations

The Use of Probiotics in Gastrointestinal Disease

2001 • 127 citations

Regulation of Human β-Defensins by Gastric Epithelial Cells in Response to Infection withHelicobacter pylorior Stimulation with Interleukin-1

2000 • 120 citations

Enteral versus parenteral nutrition: the significance of bacterial translocation and gut-barrier function

2000 • 116 citations

An essential amino acid induces epithelial β-defensin expression

2000 • 113 citations

Lactoferrin protects gut mucosal integrity during endotoxemia induced by lipopolysaccharide in mice.

2000 • 105 citations

Defensins – innate immunity at the epithelial frontier

2001 • 102 citations

A 450-kb contig of defensin genes on human chromosome 8p23

1999 • 100 citations

Intestinal mucins in colonization and host defense against pathogens.

1999 • 94 citations

Expression of antimicrobial neutrophil defensins in epithelial cells of active inflammatory bowel disease mucosa

2002 • 84 citations

Innate immunity and colonic inflammation: enhanced expression of epithelial alpha-defensins.

2002 • 83 citations

The Salmonella typhimurium Flagellar Basal Body Protein FliE Is Required for Flagellin Production and to Induce a Proinflammatory Response in Epithelial Cells

2002 • 72 citations

Development of Intestinal Microbiota

1997 • 67 citations

Identification of an Inhibitor of Tissue-type Plasminogen Activator-mediated Fibrinolysis in Human Neutrophils

1995 • 61 citations

Short-Chain Fatty Acids in Ulcerative Colitis

2009 • 60 citations

Lessons from genetic models of inflammatory bowel disease.

1997 • 59 citations

Trafficking of Shigella Lipopolysaccharide in Polarized Intestinal Epithelial Cells

1999 • 55 citations

Antimicrobial Protection of the Mouse Testis: Synthesis of Defensins of the Cryptdin Family1

1997 • 54 citations

Toll-like receptors (TLRs) signalling and expression pattern

2001 • 39 citations

Activation of Mitogen-activated Protein Kinases p42/44, p38, and Stress-activated Protein Kinases in Myelo-monocytic Cells byTreponema Lipoteichoic Acid

2001 • 37 citations

Microbiological evaluation of jejunal aspirates and faecal samples after oral administration of bifidobacteria and lactic acid bacteria

1994 • 35 citations

Antimicrobial peptides in innate intestinal host defence

2000 • 19 citations

Role of cytoplasmic and secretory phospholipase A2 in intestinal epithelial cell prostaglandin E2 formation.

2000 • 16 citations

Lysozyme localization in normal and diseased human gastric and colonic mucosa

1992 • 16 citations