Microbial modulation of innate defense: goblet cells and the intestinal mucus layer

Temperature Gradient Gel Electrophoresis Analysis of 16S rRNA from Human Fecal Samples Reveals Stable and Host-Specific Communities of Active Bacteria

1998 • 1,347 citations

Developmental microbial ecology of the neonatal gastrointestinal tract

1999 • 1,344 citations

A Light and Electron Microscopic Study

1976 • 1,232 citations

Epithelial Mucin Genes

1995 • 982 citations

Glycosyltransferases

1989 • 904 citations

Probiotics inhibit enteropathogenicE. coliadherence in vitro by inducing intestinal mucin gene expression

1999 • 820 citations

Influences of microbiota on intestinal immune system development

1999 • 752 citations

Antibody to Interleukin-5 Inhibits Helminth-Induced Eosinophilia in Mice

1989 • 635 citations

INFECTIONS OF THE GASTRO-INTESTINAL TRACT

1980 • 631 citations

A Model of Host-Microbial Interactions in an Open Mammalian Ecosystem

1996 • 619 citations

Emergence of permanently differentiated cell clones in a human colonic cancer cell line in culture after treatment with sodium butyrate.

1984 • 532 citations

The Structure and Assembly of Secreted Mucins

1999 • 523 citations

Infections of the Gastrointestinal Tract

1996 • 506 citations

A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem

1999 • 493 citations

IL-4 Induces Mucin Gene Expression and Goblet Cell Metaplasia In Vitro and In Vivo

1999 • 453 citations

Physiology of the Gastrointestinal Tract

1988 • 438 citations

Growth adaptation to methotrexate of HT-29 human colon carcinoma cells is associated with their ability to differentiate into columnar absorptive and mucus-secreting cells.

1990 • 414 citations

Role of Cytokines and CD4+ T‐Cell Subsets in the Regulation of Parasite Immunity and Disease

1989 • 405 citations

The gnotobiotic animal as a tool in the study of host microbial relationships

1971 • 382 citations

Human colonic adenocarcinoma cells

1976 • 375 citations

Mucin secretion is modulated by luminal factors in the isolated vascularly perfused rat colon

2000 • 363 citations

Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1.

1986 • 355 citations

Absorptive and mucus-secreting subclones isolated from a multipotent intestinal cell line (HT-29) provide new models for cell polarity and terminal differentiation.

1987 • 343 citations

Activation of NF-κB via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa -induced mucin overproduction in epithelial cells

1998 • 335 citations

Mucin gene structure and expression: protection vs. adhesion

1995 • 321 citations

Mucin degradation in human colon ecosystems. Isolation and properties of fecal strains that degrade ABH blood group antigens and oligosaccharides from mucin glycoproteins.

1985 • 314 citations

Probiotics A critical review

1999 • 310 citations

Molecular analysis of the composition of the bifidobacterial and lactobacillus microflora of humans

1996 • 304 citations

Proteinaceous Bacterial Adhesins and Their Receptors

1982 • 301 citations

Probiotics-A Critical Review.

1999 • 300 citations

Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells

1999 • 286 citations

Mucin Degradation in Human Colon Ecosystems

1981 • 274 citations

Histochemistry of the surface mucous gel layer of the human colon.

1997 • 263 citations

Application of denaturant gradient gel electrophoresis for the analysis of the porcine gastrointestinal microbiota

1999 • 263 citations

Mucin degradation in the human colon: production of sialidase, sialate O-acetylesterase, N-acetylneuraminate lyase, arylesterase, and glycosulfatase activities by strains of fecal bacteria

1992 • 261 citations

Regulation and biological function of helminth-induced cytokine responses

1991 • 260 citations

Differential expression of the human mucin genes MUC1 to MUC5 in relation to growth and differentiation of different mucus-secreting HT-29 cell subpopulations

1993 • 258 citations

Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils.

1999 • 244 citations

Mucin gene (MUC 2 and MUC 5AC) upregulation by Gram-positive and Gram-negative bacteria

1998 • 228 citations

Comparative histochemistry of gastrointestinal mucosubstances

1976 • 228 citations

Th2-Induced Airway Mucus Production Is Dependent on IL-4Rα, But Not on Eosinophils

1999 • 192 citations

Mucus from Marine Molluscs

1998 • 192 citations

Denaturing Gradient Gel Electrophoresis Analysis of 16S Ribosomal DNA Amplicons To Monitor Changes in Fecal Bacterial Populations of Weaning Pigs after Introduction of Lactobacillus reuteri Strain MM53

2000 • 188 citations

Tumor and lymphoid cell lines from a patient with carcinoma of the colon for a cytotoxicity model.

1978 • 185 citations

Glycoproteins and Their Relationship to Human Disease

1998 • 182 citations

The Attachment of Bacteria to the Surfaces of Animal Cells

1977 • 178 citations

Alteration of Gastrointestinal Mucin by Fiber Feeding in Rats

1990 • 165 citations

Molecular Ecological Analysis of the Succession and Diversity of Sulfate-Reducing Bacteria in the Mouse Gastrointestinal Tract

2000 • 156 citations

The transcriptional responses of respiratory epithelial cells toBordetella pertussisreveal host defensive and pathogen counter-defensive strategies

2000 • 154 citations

Diet-dependent and diet-independent metabolic responses underlie growth stasis of pigs at weaning.

1995 • 152 citations

Rat intestinal mucosal responses to a microbial flora and different diets.

1995 • 150 citations

Proinflammatory cytokines trigger MUC gene expression and mucin release in the intestinal cancer cell line LS180

2000 • 146 citations

Purification and characterization of a membrane-bound and a secreted mucin-type glycoprotein carrying the carcinoma-associated sialyl-Lea epitope on distinct core proteins.

1991 • 146 citations

Bacterial Glycosulphatases and Sulphomucin Degradation

1997 • 143 citations

Inhibition of gastric mucin synthesis by Helicobacter pylori

2000 • 141 citations

Microbial flora of the mouse ileum mucous layer and epithelial surface

1982 • 131 citations

Histochemical, Lectin-Histochemical and Morphometrical Characteristics of Intestinal Goblet Cells of Germfree and Conventional Mice.

1996 • 126 citations

Development of resistance with host age to adhesion of K99+ Escherichia coli to isolated intestinal epithelial cells

1980 • 126 citations

Dietary fibre and intestinal microflora: effects on intestinal morphometry and crypt branching

1998 • 125 citations

Review

1998 • 124 citations

Characterization of Binding of Candida albicans to Small Intestinal Mucin and Its Role in Adherence to Mucosal Epithelial Cells

2000 • 120 citations

Recent advances in mucosal immunity

1983 • 118 citations

Probiotics and the immune system.

1999 • 116 citations

Small bowel morphology in experimental canine cholera. A light and electron microscopic study.

1970 • 113 citations

The human intestinal cell lines Caco-2 and LS174T as models to study cell-type specific mucin expression

1996 • 111 citations

Effects of neurotransmitters, gut hormones, and inflammatory mediators on mucus discharge in rat colon

1998 • 107 citations

Intestinal mucin distribution in the germ-free rat and in the heteroxenic rat harbouring a human bacterial flora: effect of inulin in the diet

1996 • 106 citations

Pre-epithelial mucus layer in the colon of conventional and germ-free rats

1990 • 102 citations

Human mucin glycoproteins: varied structures predict diverse properties and specific functions

1995 • 101 citations

Morphometric analysis of intestinal mucins under different dietary conditions and gut flora in rats

1995 • 100 citations

Prostaglandin E2 stimulates rat and human colonic mucin exocytosis via the EP4 receptor

1999 • 100 citations

Anaphylactic release of intestinal goblet cell mucus.

1980 • 99 citations

MUC2 gene suppression in human colorectal carcinomas and their metastases: in vitro evidence of the modulatory role of DNA methylation.

1997 • 99 citations

Immune-mediated alteration of the terminal sugars of goblet cell mucins in the small intestine of Nippostrongylus brasiliensis-infected rats.

1993 • 99 citations

Cloning, sequencing and distribution of the Salmonella typhimurlum LT2 siaiidase gene, nanH, provides evidence for interspecies gene transfer

1992 • 98 citations

Human intestinal goblet cells in monolayer culture: Characterization of a mucus-secreting subclone derived from the HT29 colon adenocarcinoma cell line

1988 • 98 citations

Signaling Pathways for Transduction of the Initial Message of the Glycocode into Cellular Responses

1998 • 97 citations

Early functional effects of Clostridium difficile toxin A on human colonocytes

1997 • 95 citations

Intestinal mucins in colonization and host defense against pathogens.

1999 • 94 citations

Expression and function of α2,3‐sialyl‐ and α,3/l,4‐fucosyltransferases in colon adenocarcinoma cell lines: Role in synthesis of E‐selectin counter‐receptors

1995 • 93 citations

Immunological Aspects of Host/Microbiota Interactions at the Intestinal Epithelium

1997 • 90 citations

Characterization of mucins and proteoglycans synthesized by a mucin-secreting HT-29 cell subpopulation

1995 • 87 citations

Recent advances in mucosal immunity

1982 • 87 citations

Adaptation to 5‐fluorouracil of the heterogeneous human colon tumor cell line ht‐29 results in the selection of cells committed to differentiation

1991 • 81 citations

Entamoeba Histolytica: Early Progressive Pathology in the Cecum of the Gerbil (Meriones Unguiculatus)

1985 • 81 citations

The Thioredoxin System of Helicobacter pylori

2000 • 80 citations

Mitogen-activated protein kinase activation regulates intestinal epithelial differentiation

1999 • 80 citations

Characterization of quantitative mucin variants from a human colon cancer cell line.

1987 • 79 citations

Intestinal mucins: the binding sites for Salmonella typhimurium.

2000 • 77 citations

Factors involved in colonization of the gut epithelial surface

1978 • 74 citations

Patterns of expression of lineage-specific markers during the in vitro-induced differentiation of HT29 colon carcinoma cells.

1995 • 74 citations

Differential stimulation of intestinal mucin secretion by cholera toxin and carbachol

1997 • 74 citations

Age and Diet Affect the Composition of Porcine Colonic Mucins

1993 • 72 citations

Synthesis and secretion of mucin by the human colonic tumour cell line LS180

1994 • 71 citations

Susceptibility of porcine intestine to pilus-mediated adhesion by some isolates of piliated enterotoxigenic Escherichia coli increases with age

1992 • 70 citations

Mucin degradation in the human gastrointestinal tract and its significance to enteric microbial ecology

1993 • 69 citations

Reduced amount of intestinal mucus by treatment with anti‐CD4 antibody interferes with the spontaneous cure of Nippostrongylus brasiliensis‐infection in mice

1995 • 67 citations

Mucin exocytosis: a major target for Helicobacter pylori.

1993 • 63 citations

Age-specific colonization of porcine intestinal epithelium by 987P-piliated enterotoxigenic Escherichia coli

1989 • 62 citations

Bacterial toxin interaction with the developing intestine

1993 • 59 citations

Human mucin genes: genomic organization and expression of MUC4, MUC5AC and MUC5B

1995 • 59 citations

Tumor Necrosis Factor (TNFα) Regulates Intestinal Mucus Production during Salmonellosis

1993 • 58 citations

Glycosylation patterns of mucins in colonic disease

1995 • 57 citations

A histochemical study of glycogen and mucin in developing human foetal epithelia

1968 • 56 citations

Variation of mucin distribution in the rat intestine, caecum and colon: effect of the bacterial flora

1999 • 56 citations

Mucin and nonmucin secretagogue activity of Entamoeba histolytica and cholera toxin in rat colon

1991 • 54 citations

Induction of mucin gene expression in human colonic cell lines by PMA is dependent on PKC-ε

1999 • 53 citations

Total Parenteral Nutrition Decreases Luminal Mucous Gel and Increases Permeability of Small Intestine

1994 • 51 citations

Listeria monocytogenesStimulates Mucus Exocytosis in Cultured Human Polarized Mucosecreting Intestinal Cells through Action of Listeriolysin O

1998 • 49 citations

The influence of diets and gut microflora on lectin binding patterns of intestinal mucins in rats.

1995 • 48 citations

Total Parenteral Nutrition Alters Molecular and Cellular Indices of Intestinal Inflammation in Neonatal Piglets

1999 • 48 citations

Changes in colonic mucins of germfree rats in response to the introduction of a "normal" rat microbial flora. Rat colonic mucin.

1992 • 48 citations

Morphological characteristics, epithelial cell proliferation, and crypt fission in cecum and colon of growing pigs.

1997 • 47 citations

Interaction of cholera toxin with cloned human goblet cells in monolayer culture

1990 • 46 citations

Studies on the role of mucus and mucosalhypersensitivity reactions during rejection ofTrichostrongylus colubriformis from the intestine ofimmune sheep using an experimental challenge model

1999 • 44 citations

Germfree and Gnotobiotic Animal Models: Background and Applications

1996 • 43 citations

Intestinal mucus entrapment of Trichinella spiralis larvae induced by specific antibodies.

1991 • 43 citations

Production of MUC1 and MUC2 mucins by human tumor cell lines

1991 • 42 citations

Glycosulfatase activity of helicobacter pylori toward gastric mucin

1992 • 39 citations

A glycosyl hydrolase activity of mammalian reovirus σ1 protein can contribute to viral infection through a mucus layer 1 1Edited by M. Yaniv

1999 • 36 citations

Mucin-secreting cells in rats infected with Nippostrongylus brasiliensis

1963 • 35 citations

Effects of Perorally Applied Endotoxin on Colonic Mucins of Germfree Rats

1996 • 35 citations

A mucus-secreting human colonic cancer cell line. Purification and partial characterization of the secreted mucins

1989 • 34 citations

Expression of MUC1 and MUC2 Mucins by Human Tumor Cell Lines

1992 • 34 citations

Interferon-γ modulates cAMP-induced mucin exocytosis without affecting mucin gene expression in a human colonic goblet cell line

1994 • 32 citations

Effects of diet on acidic and neutral goblet cell populations in the small intestine of early weaned pigs.

1991 • 31 citations

Effect of Helicobacter pylori lipopolysaccharide on the synthesis of sulfated gastric mucin.

1992 • 30 citations

INTESTINAL WATER—SOLUBLE MUCINS IN GERMFREE, EXGERMFREE AND CONVENTIONAL ANIMALS

1984 • 28 citations

Direct secretory effect of interleukin-1 via type I receptors in human colonic mucous epithelial cells (HT29-C1.16E).

1996 • 27 citations

Microbial Interactions

1978 • 27 citations

The fast release of mucin secretion from human colonic cells induced by Entamoeba histolytica is dependent on contact and protein kinase C activation.

1992 • 27 citations

Mucins secreted by cell lines derived from colorectal mucinous carcinoma and adenocarcinoma

1997 • 27 citations

Functional Heterogeneity of Colonic Adenocarcinoma Mucins for Inhibition of Entamoeba histolytica Adherence to Target Cells1

1998 • 27 citations

Sulphomucins favour adhesion of Helicobacter pylori to metaplastic gastric mucosa.

1999 • 24 citations

Effects of diet on acidic and neutral goblet cell populations in the small intestine of early weaned pigs

1991 • 23 citations

Influence of colonizing micro-flora on the mucin histochemistry of the neonatal mouse colon

1990 • 23 citations

Advances in Microbial Ecology

1984 • 19 citations

Influence of conventionalization on cecal wall structure of germ-free Wistar rats: quantitative light and qualitative electron microscopic observations

1989 • 18 citations

Adverse Host Responses to Bacterial Toxins in Human Infants

2000 • 17 citations

Recent aspects of the regulation of intestinal mucus secretion

1996 • 16 citations

Biosynthesis of two distinct types of mucin in HM3 human colon cancer cells

1994 • 15 citations

Goblet cell mucin in human foetal colon, its composition and susceptibility to enzyme degradation: a histochemical study.

1989 • 11 citations

A cell line (LIM 2463) derived from a tubulovillous adenoma of the rectum

1991 • 9 citations

Deleted Work

1955 • 0 citations

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