Defensins – innate immunity at the epithelial frontier

β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6

1999 • 1,760 citations

Peptide Antibiotics and Their Role in Innate Immunity

1995 • 1,602 citations

Defensins. Natural peptide antibiotics of human neutrophils.

1985 • 1,411 citations

Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

1999 • 1,069 citations

Human β-Defensin-1 Is a Salt-Sensitive Antibiotic in Lung That Is Inactivated in Cystic Fibrosis

1997 • 1,069 citations

Cystic Fibrosis Airway Epithelia Fail to Kill Bacteria Because of Abnormal Airway Surface Fluid

1996 • 1,042 citations

Defensins: Antimicrobial and Cytotoxic Peptides of Mammalian Cells

1993 • 986 citations

Activation of nuclear factor kappa B in inflammatory bowel disease

1998 • 736 citations

Human beta-defensin-1: an antimicrobial peptide of urogenital tissues.

1998 • 733 citations

Antimicrobial peptides in mammalian and insect host defence

1999 • 723 citations

Nuclear factor κB is activated in macrophages and epithelial cells of inflamed intestinal mucosa

1998 • 696 citations

Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium.

1999 • 602 citations

Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung.

1998 • 577 citations

Production of β-defensins by human airway epithelia

1998 • 574 citations

Widespread expression of beta‐defensin hBD‐1 in human secretory glands and epithelial cells

1996 • 571 citations

Identification of Defensin-1, Defensin-2, and CAP37/Azurocidin as T-cell Chemoattractant Proteins Released from Interleukin-8-stimulated Neutrophils

1996 • 551 citations

hBD‐1: a novel β‐defensin from human plasma

1995 • 547 citations

Paneth cells of the human small intestine express an antimicrobial peptide gene

1992 • 525 citations

Expression and Regulation of the Human β-Defensins hBD-1 and hBD-2 in Intestinal Epithelium

1999 • 496 citations

Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells

2000 • 489 citations

MucoidPseudomonas aeruginosa, TNF- α , and IL-1 β , but Not IL-6, Induce Human β -Defensin-2 in Respiratory Epithelia

2000 • 409 citations

Inducible Expression of Human β-Defensin 2 byFusobacterium nucleatumin Oral Epithelial Cells: Multiple Signaling Pathways and Role of Commensal Bacteria in Innate Immunity and the Epithelial Barrier

2000 • 406 citations

Production of β-Defensin Antimicrobial Peptides by the Oral Mucosa and Salivary Glands

1999 • 366 citations

Interactions between human defensins and lipid bilayers: Evidence for formation of multimeric pores

1994 • 349 citations

Defensin‐6 mRNA in human Paneth cells: implications for antimicrobia peptides in host defense of the human bowel

1993 • 348 citations

Defensins

1994 • 325 citations

Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract.

1998 • 321 citations

CD14-dependent Lipopolysaccharide-induced β-Defensin-2 Expression in Human Tracheobronchial Epithelium

2000 • 309 citations

Mechanisms for induction of acquired host immunity by neutrophil peptide defensins

1999 • 301 citations

Human Enteric Defensins

1996 • 301 citations

Expression of the Peptide Antibiotic Human β-Defensin 1 in Cultured Gingival Epithelial Cells and Gingival Tissue

1998 • 278 citations

Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells.

1996 • 277 citations

Human airway epithelia express a beta-defensin.

1997 • 264 citations

Structure and mapping of the human β-defensin HBD-2 gene and its expression at sites of inflammation

1998 • 257 citations

Defensins

1995 • 256 citations

Broad-spectrum antimicrobial activity of human intestinal defensin 5

1997 • 228 citations

Epithelial antibiotic induced in states of disease

1997 • 223 citations

Gene‐Encoded Peptide Antibiotics and the Concept of Innate Immunity: An Update Review

1998 • 219 citations

The Human β-Defensin-1 and α-Defensins Are Encoded by Adjacent Genes: Two Peptide Families with Differing Disulfide Topology Share a Common Ancestry

1997 • 212 citations

Defensins are mitogenic for epithelial cells and fibroblasts

1993 • 199 citations

Localization of human intestinal defensin 5 in Paneth cell granules

1997 • 188 citations

Enteric β-Defensin: Molecular Cloning and Characterization of a Gene with Inducible Intestinal Epithelial Cell Expression Associated with Cryptosporidium parvum Infection

1998 • 179 citations

Defensins and innate host defence of the gastrointestinal tract

1999 • 177 citations

Antimicrobial defensin peptides of the human ocular surface

1999 • 170 citations

Prognostic factors in patients with Zollinger-Ellison syndrome and multiple endocrine neoplasia type 1

1999 • 169 citations

Epithelial peptide antibiotics

1999 • 165 citations

Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha

1996 • 160 citations

Identification of Human β-Defensin-2 in Respiratory Tract and Plasma and Its Increase in Bacterial Pneumonia

1998 • 151 citations

Defensins promote fusion and lysis of negatively charged membranes

1993 • 150 citations

β-Defensins: Endogenous Antibiotics of the Innate Host Defense Response

1998 • 144 citations

Solution Structure of Bovine Neutrophil .beta.-Defensin-12: The Peptide Fold of the .beta.-Defensins Is Identical to That of the Classical Defensins

1995 • 142 citations

Enteric Defensin Expression in Necrotizing Enterocolitis

1998 • 137 citations

Ocular Surface Epithelia Express mRNA for Human Beta Defensin-2

1999 • 123 citations

Regulation of Human β-Defensins by Gastric Epithelial Cells in Response to Infection withHelicobacter pylorior Stimulation with Interleukin-1

2000 • 120 citations

Detection of human defensin 5 in reproductive tissues

1997 • 114 citations

Mapping of the Gene Encoding Human β-Defensin-2 (DEFB2) to Chromosome Region 8p22–p23.1

1997 • 113 citations

Defensin-1, a peptide detected in the saliva of oral squamous cell carcinoma patients.

1999 • 81 citations

Human beta-defensin-1: A urinary peptide present in variant molecular forms and its putative functional implication.

1998 • 78 citations

Isolation of human intestinal defensins from ileal neobladder urine

1998 • 75 citations

Human Enteric Defensin Genes: Chromosomal Map Position and a Model for Possible Evolutionary Relationships

1996 • 75 citations

β-Defensin Expression in Human Mammary Gland Epithelia

2000 • 72 citations

Reduced antimicrobial peptide expression in human burn wounds

1999 • 70 citations

Structural Analysis of Human β-Defensin-1 and Its Significance in Urinary Tract Infection

2000 • 69 citations

Localization of expression of human beta defensin-1 in the pancreas and kidney.

1998 • 68 citations

Peptide Antibiotics: Holy or Heretic Grails of Innate Immunity?

1996 • 68 citations

Differential expression of human α‐ and β‐defensins mRNA in gastrointestinal epithelia

2000 • 67 citations

Induction of Human β-Defensin-2 mRNA Expression by Helicobacter pylori in Human Gastric Cell Line MKN45 Cells on cag Pathogenicity Island

1999 • 65 citations

Antibacterial Peptides in Bronchoalveolar Lavage Fluid

1998 • 61 citations

Detection of Human Defensins in the Placenta

1997 • 61 citations

Pattern of expression of beta-defensins in oral squamous cell carcinoma

1999 • 58 citations

Polymorphisms of the humanβ-defensin-1gene

1998 • 58 citations

Expression of β‐defensin genes by human salivary glands

1999 • 56 citations

Expression of human beta-defensins in intraocular tissues.

2000 • 54 citations

Investigation of beta defensin gene expression in the ocular anterior segment by semiquantitative RT-PCR

2000 • 43 citations

Human beta defensin 1 gene: Six new variants

2000 • 27 citations

Presence of human beta-defensin-2 in oral squamous cell carcinoma.

2000 • 19 citations

Effect of defensins on the blood level of corticosterone and the immune response during stress

1993 • 9 citations

Tympanometric Hysteresis Effect and Errors in Middle Ear Pressure Determination - a Preliminary Study in Children with Secretory Otitis Media

2000 • 8 citations