IFN-γ Receptor Signaling Is Essential for the Initiation, Acceleration, and Destruction of Autoimmune Kidney Disease in MRL-FaslprMice

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Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice.

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IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL/Ipr mice.

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IFN-γ Is Critical for Long-Term Allograft Survival Induced by Blocking the CD28 and CD40 Ligand T Cell Costimulation Pathways

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An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity.

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Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice.

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Interaction of mutant lpr gene with background strain influences renal disease

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Regulation of monocyte chemoattractant protein-1 and macrophage colony-stimulating factor-1 by IFN-gamma, tumor necrosis factor-alpha, IgG aggregates, and cAMP in mouse mesangial cells.

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IgG3 production in MRL/lpr mice is responsible for development of lupus nephritis.

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Biphasic increase in circulating and renal TNF-α in MRL-lpr mice with differing regulatory mechanisms

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Treatment of autoimmune MRL/Ipr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease.

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Macrophage Growth Factors Introduced into the Kidney Initiate Renal Injury

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Autoreactive kidney-infiltrating T-cell clones in murine lupus nephritis

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Apoptosis in proliferative glomerulonephritis: decreased apoptosis expression in lupus nephritis

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The lpr gene causes an intrinsic T cell abnormality that is required for hyperproliferation.

1988 • 57 citations

TNF-alpha enhances colony-stimulating factor-1-induced macrophage accumulation in autoimmune renal disease.

1996 • 41 citations

Systemic autoimmune nephritogenic components induce CSF-1 and TNF-α in MRL kidneys

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IFN-γ Limits Macrophage Expansion in MRL-FaslprAutoimmune Interstitial Nephritis: A Negative Regulatory Pathway

1998 • 28 citations

Self-regulation of autoreactive kidney-infiltrating T cells in MRL-lpr nephritis

1993 • 21 citations