IFN-gamma receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Fas(lpr) mice.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 2,450 citations

THE GROWTH OF MOUSE BONE MARROW CELLS IN VITRO

1966 • 1,944 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

1988 • 845 citations

Biology of the Laboratory Mouse

1941 • 826 citations

Etiopathogenesis of Murine SLE¹

1981 • 517 citations

Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice.

1998 • 354 citations

Mechanisms of apoptosis and its potential role in renal tubular epithelial cell injury

1996 • 334 citations

Increased tumor necrosis factor and IL-1 beta gene expression in the kidneys of mice with lupus nephritis.

1988 • 321 citations

Roles of interferon-gamma and interleukin-4 in murine lupus.

1997 • 301 citations

Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene.

1993 • 287 citations

IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways.

1998 • 275 citations

Apoptosis in glomerular sclerosis

1996 • 257 citations

Tumor necrosis factor and IL-1 in New Zealand Black/White mice. Enhanced gene expression and acceleration of renal injury.

1989 • 255 citations

IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL/Ipr mice.

1997 • 254 citations

An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity.

1991 • 198 citations

Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice.

1994 • 194 citations

Treatment of murine lupus with monoclonal anti-T cell antibody.

1985 • 186 citations

Activation-induced apoptosis in human macrophages: developmental regulation of a novel cell death pathway by macrophage colony-stimulating factor and interferon gamma.

1995 • 174 citations

Interaction of mutant lpr gene with background strain influences renal disease

1985 • 168 citations

Regulation of monocyte chemoattractant protein-1 and macrophage colony-stimulating factor-1 by IFN-gamma, tumor necrosis factor-alpha, IgG aggregates, and cAMP in mouse mesangial cells.

1993 • 147 citations

IgG3 production in MRL/lpr mice is responsible for development of lupus nephritis.

1991 • 142 citations

Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells

1995 • 141 citations

Polyreactive autoantibodies are nephritogenic in murine lupus nephritis.

1987 • 139 citations

Cryoglobulinemia induced by a murine IgG3 rheumatoid factor: skin vasculitis and glomerulonephritis arise from distinct pathogenic mechanisms.

1990 • 122 citations

Regulation of Fas and Fas ligand expression in cultured murine renal cells and in the kidney during endotoxemia

1996 • 104 citations

Mesangial cell accessory functions: Mediation by intercellular adhesion molecule-1

1990 • 97 citations

Biphasic increase in circulating and renal TNF-α in MRL-lpr mice with differing regulatory mechanisms

1995 • 91 citations

Systemic mononuclear-cell vasculitis in MRL/Mp-lpr/lpr mice. A histologic and immunocytochemical analysis.

1987 • 90 citations

Colony stimulating factor-1 in the induction of lupus nephritis

1993 • 82 citations

Treatment of autoimmune MRL/Ipr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease.

1983 • 76 citations

Macrophage Growth Factors Introduced into the Kidney Initiate Renal Injury

1996 • 69 citations

Autoreactive kidney-infiltrating T-cell clones in murine lupus nephritis

1992 • 66 citations

Increased macrophage colony-stimulating factor in neonatal and adult autoimmune MRL-lpr mice.

1991 • 64 citations

Apoptosis in proliferative glomerulonephritis: decreased apoptosis expression in lupus nephritis

1997 • 60 citations

B cells in systemic autoimmune disease: recent insights from Fas-deficient mice and men

1996 • 60 citations

The lpr gene causes an intrinsic T cell abnormality that is required for hyperproliferation.

1988 • 57 citations

TNF-alpha enhances colony-stimulating factor-1-induced macrophage accumulation in autoimmune renal disease.

1996 • 41 citations

IFN-gamma limits macrophage expansion in MRL-Fas(lpr) autoimmune interstitial nephritis: a negative regulatory pathway.

1998 • 38 citations

Systemic autoimmune nephritogenic components induce CSF-1 and TNF-α in MRL kidneys

1997 • 38 citations

Enhanced interferon-gamma (IFN) production by lymph node cells from autoimmune (MRL/1, MRL/n) mice.

1989 • 31 citations

Upregulation of lymphoid and renal interferon-gamma mRNA in autoimmune MRL-Fas(lpr) mice with lupus nephritis.

1997 • 30 citations

Self-regulation of autoreactive kidney-infiltrating T cells in MRL-lpr nephritis

1993 • 21 citations