Roles of interferon-gamma and interleukin-4 in murine lupus.

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.

1978 • 1,619 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice.

1994 • 543 citations

Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.

1993 • 506 citations

In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon.

1987 • 396 citations

Induction of various autoantibodies by mutant gene lpr in several strains of mice.

1984 • 390 citations

The Roles of Costimulation and Fas in T Cell Apoptosis and Peripheral Tolerance

1996 • 367 citations

The role of B cells in lpr/lpr-induced autoimmunity.

1994 • 356 citations

The role of IFN-gamma in delayed-type hypersensitivity mediated by Th1 clones.

1989 • 304 citations

Abnormalities induced by the mutant gene Ipr: expansion of a unique lymphocyte subset.

1982 • 295 citations

Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene.

1993 • 287 citations

Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice.

1996 • 265 citations

The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn.

1993 • 241 citations

Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen.

1993 • 234 citations

The contribution of L3T4+ T cells to lymphoproliferation and autoantibody production in MRL-lpr/lpr mice.

1988 • 232 citations

Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites

1992 • 217 citations

An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity.

1991 • 198 citations

Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice.

1994 • 194 citations

Experimental therapy of systemic lupus erythematosus: the treatment of NZB/W mice with mouse soluble interferon‐γ receptor inhibits the onset of glomerulonephritis

1995 • 188 citations

Murine monoclonal anti-DNA antibodies penetrate cells, bind to nuclei, and induce glomerular proliferation and proteinuria in vivo.

1992 • 178 citations

Presence of anti-Sm reactivity in autoimmune mouse strains

1978 • 168 citations

Propagation and regulation of systemic autoimmunity by gammadelta T cells.

1996 • 155 citations

Murine lupus in the absence of alpha beta T cells.

1996 • 151 citations

Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells

1995 • 141 citations

Peripheral T cells undergoing superantigen-induced apoptosis in vivo express B220 and upregulate Fas and Fas ligand.

1996 • 141 citations

The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice.

1996 • 128 citations

Quantitative polymerase chain reaction analysis reveals marked overexpression of interleukin-1β, interleukin-10 and interferon-γ mRNA in the lymph nodes of lupus-prone mice

1995 • 120 citations

Inquiry into Murine and Human Lupus

1995 • 111 citations

B cell dependence on and response to accessory signals in murine lupus strains.

1983 • 108 citations

Stochastic control of anti-Sm autoantibodies in MRL/Mp-lpr/lpr mice.

1987 • 100 citations

Sialadenitis in the MRL-l mouse: morphological and immunohistochemical characterization of resident and infiltrating cells.

1987 • 96 citations

24. Animal Models for Human Disease

2019 • 86 citations

Transcriptional Repression and Differential Splicing of Fas m-RNA by Early Transposon (ETn) Insertion in Autoimmune LPR Mice

1993 • 80 citations

Evidence for an intrinsic B cell defect in lpr/lpr mice apparent in neonatal chimeras.

1990 • 76 citations

Complement—immunoglobulin interactions

1995 • 76 citations

lpr And gld: Single Gene Models Of Systemic Autoimmunity And Lymphoproliferative Disease

1991 • 74 citations

Studies of congenic MRL-Ipr/Ipr.xid mice.

1983 • 72 citations

B lymphocytes from the autoimmune-prone mouse strain MLR/lpr manifest an intrinsic defect in tetraparental MRL/lpr in equilibrium DBA/2 chimeras.

1991 • 63 citations

lpr T cells are necessary for autoantibody production in lpr mice.

1993 • 60 citations

The lpr gene causes an intrinsic T cell abnormality that is required for hyperproliferation.

1988 • 57 citations

Subclass restriction of anti-Sm antibodies in MRL mice.

1982 • 53 citations

The recruitment of lymphocytes into the skin by T cell lymphokines: the role of gamma-interferon.

1988 • 51 citations

Abnormal Splenic and Thymic IL‐4 and TNF‐α Expression in MRL‐lpr/lpr Mice

1995 • 45 citations

T cell-independent and T cell-dependent B cell activation increases IFN-gamma R expression and renders B cells sensitive to IFN-gamma-mediated inhibition.

1994 • 32 citations

Modulation of the immunoglobulin dysregulation in GvH- and SLE-like diseases by the murine IL-4 receptor (IL-4-R)

1995 • 32 citations

Expression of lymphokine genes in splenic lymphocytes of autoimmune mice

1989 • 29 citations

The genetics of autoantibody production in MRL/lpr lupus mice.

1989 • 24 citations

In vivo treatment with a monoclonal antibody to interferon-gamma neither affects the survival nor the incidence of lupus-nephritis in the MRL/lpr-lpr mouse

1992 • 24 citations

Glomerular Lesions in MRL mice A Light and Immunofluorescence Microscopic Study*

1986 • 14 citations

ANIMAL MODELS OF HUMAN DISEASE. Transgenic and Knockout Models of Autoimmunity: Building a Better Disease?

1996 • 9 citations

Stochastic control of anti-Sm autoantibodies in MRL/Mp-lpr/lpr mice.

1987 • 6 citations

The lpr gene causes an intrinsic T cell abnormality that is required for hyperproliferation

1988 • 6 citations