Antigen-Specific Therapy of Murine Lupus Nephritis Using Nucleosomal Peptides: Tolerance Spreading Impairs Pathogenic Function of Autoimmune T and B Cells

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

1998 • 3,085 citations

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

1994 • 1,722 citations

Antinuclear Antibodies: Diagnostic Markers for Autoimmune Diseases and Probes for Cell Biology

1989 • 1,543 citations

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

A very high level of crossreactivity is an essential feature of the T-cell receptor

1998 • 930 citations

Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

1998 • 685 citations

Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus.

1993 • 637 citations

Systemic Exposure to Irradiated Apoptotic Cells Induces Autoantibody Production

1998 • 573 citations

Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production.

1996 • 516 citations

Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens.

1992 • 435 citations

Antigen-induced B-cell death and elimination during germinal-centre immune responses

1995 • 377 citations

Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis.

1995 • 371 citations

Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes.

1996 • 360 citations

Synovium as a source of increased amino-terminal parathyroid hormone-related protein expression in rheumatoid arthritis. A possible role for locally produced parathyroid hormone-related protein in the pathogenesis of rheumatoid arthritis.

1998 • 340 citations

Systemic autoimmune disease arises from polyclonal B cell activation.

1987 • 314 citations

A New Role for B Cells in Systemic Autoimmunity: B Cells Promote Spontaneous T Cell Activation in MRL-lpr/lprMice

1998 • 301 citations

Induction of a cationic shift in IgG anti-DNA autoantibodies. Role of T helper cells with classical and novel phenotypes in three murine models of lupus nephritis.

1987 • 236 citations

B cells process and present lupus autoantigens that initiate autoimmune T cell responses.

1994 • 236 citations

Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen.

1993 • 234 citations

Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus.

1996 • 221 citations

B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events.

1996 • 220 citations

A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire.

1994 • 216 citations

Specific T cell recognition of minimally homologous peptides: Evidence for multiple endogenous Ligands

1995 • 209 citations

Review: Nephritogenic autoantibodies in lupus: Current concepts and continuing controversies

1996 • 207 citations

Nucleosome‐restricted antibodies are detected before anti‐dsdna and/or antihistone antibodies in serum of mrl‐mp lpr/lpr and +/+ mice, and are present in kidney eluates of lupus mice with proteinuria

1994 • 207 citations

Anti-CD40 Ligand Antibody Treatment of SNF1 Mice with Established Nephritis: Preservation of Kidney Function

1998 • 202 citations

Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes.

1997 • 190 citations

Peptide inhibition of glomerular deposition of an anti-DNA antibody

1997 • 186 citations

Structure and specificity of T cell receptors expressed by potentially pathogenic anti-DNA autoantibody-inducing T cells in human lupus.

1995 • 165 citations

Lupus nephritis

1997 • 165 citations

Antibodies to histones in systemic lupus erythematosus: localization of prominent autoantigens on histones H1 and H2B.

1983 • 158 citations

Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology.

1998 • 156 citations

Roles of IL-4 and IL-12 in the development of lupus in NZB/W F1 mice.

1997 • 153 citations

Comparison of pathogenic and non-pathogenic murine antibodies to DNA: antigen binding and structural characteristics

1994 • 150 citations

B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes.

1995 • 149 citations

In the absence of a CD40 signal, B cells are tolerogenic

1995 • 149 citations

Degenerate recognition of a dissimilar antigenic peptide by myelin basic protein-reactive T cells. Implications for thymic education and autoimmunity.

1993 • 149 citations

Histone‐specific Th0 and Th1 clones derived from systemic lupus erythematosus patients induce double‐stranded DNA antibody production

1997 • 141 citations

Self antigens and epitope spreading in systemic autoimmunity

1997 • 140 citations

Antigen-unspecific B Cells and Lymphoid Dendritic Cells Both Show Extensive Surface Expression of Processed Antigen–Major Histocompatibility Complex Class II Complexes after Soluble Protein Exposure In Vivo or In Vitro

1997 • 128 citations

Cutting Edge: Predictable TCR Antigen Recognition Based on Peptide Scans Leads to the Identification of Agonist Ligands with No Sequence Homology

1998 • 118 citations

Inhibition of experimental autoimmune encephalomyelitis induction in SJL/J mice by using a peptide with high affinity for IAs molecules.

1990 • 118 citations

Antibodies from patients with drug-induced and idiopathic lupus erythematosus react with epitopes restricted to the amino and carboxyl termini of histone.

1985 • 101 citations

Immune tolerance to autoantibody-derived peptides delays development of autoimmunity in murine lupus.

1995 • 100 citations

VH‐Gene Representation in Autoantibodies Reflects the Normal Human B‐Cell Repertoire

1992 • 99 citations

I-Ad-binding peptides derived from unrelated protein antigens share a common structural motif.

1988 • 94 citations

Genetic basis of systemic lupus erythematosus

1996 • 92 citations

Junctional region sequences of T-cell receptor beta-chain genes expressed by pathogenic anti-DNA autoantibody-inducing helper T cells from lupus mice: possible selection by cationic autoantigens.

1991 • 90 citations

Systemic antigen in the treatment of T-cell-mediated autoimmune diseases

1997 • 85 citations

Promiscuous Presentation and Recognition of Nucleosomal Autoepitopes in Lupus: Role of Autoimmune T Cell Receptor α Chain

1998 • 84 citations

Autoimmunity caused by disruption of central T cell tolerance. A murine model of drug-induced lupus.

1997 • 82 citations

CD4+ T cell lines with selective patterns of autoreactivity as well as CD4- CD8- T helper cell lines augment the production of idiotypes shared by pathogenic anti-DNA autoantibodies in the NZB x SWR model of lupus nephritis.

1988 • 78 citations

Analysis of recombinant inbred lines derived from "autoimmune" (NZB) and "high leukemia" (C58) strains: independent multigenic systems control B cell hyperactivity, retrovirus expression, and autoimmunity.

1982 • 69 citations

ANTIBODIES TO HISTONES IN SYSTEMIC LUPUS ERYTHEMATOSUS AND DRUG-INDUCED LUPUS SYNDROMES

1992 • 67 citations

Genetic analysis of the inheritance of B cell hyperactivity in relation to the development of autoantibodies and glomerulonephritis in NZB x SWR crosses.

1983 • 65 citations

Genetic dissection of lupus nephritis in murine models of SLE.

1997 • 63 citations

Resting B cells from autoimmune lupus-prone New Zealand Black and (New Zealand Black x New Zealand White)F1 mice are hyper-responsive to T cell-derived stimuli.

1997 • 50 citations

Mapping of linear histone regions exposed at the surface of the nucleosome in solution

1997 • 42 citations

Dual Reactivity of Several Monoclonal Anti-nucleosome Autoantibodies for Double-stranded DNA and a Short Segment of Histone H3

1996 • 39 citations

Review

1996 • 36 citations

Autoimmune ovarian disease: mechanism of disease induction and prevention

1997 • 28 citations

Nucleosome‐driven Autoimmune Response in Lupus Pathogenic T Helper Cell Epitopes and Costimulatory Signals

1997 • 24 citations