Mechanisms controlling cellular suicide: role of Bcl-2 and caspases

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Apoptosis. Its significance in cancer and cancer Therapy

1994 • 2,148 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

X-linked IAP is a direct inhibitor of cell-death proteases

1997 • 1,961 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Genetic control of programmed cell death in the nematode C. elegans

1986 • 1,790 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)

1996 • 1,464 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Structure of Bcl-x _L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

1997 • 1,429 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Life, death, and the pursuit of apoptosis.

1996 • 1,333 citations

Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

1997 • 1,329 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

1994 • 1,145 citations

Role of poly(ADP-ribose) formation in DNA repair

1992 • 1,142 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 1,078 citations

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1994 • 1,043 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

1995 • 964 citations

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.

1993 • 959 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen

1993 • 857 citations

Structure and mechanism of interleukin-lβ converting enzyme

1994 • 842 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Prevention of Apoptosis by a Baculovirus Gene During Infection of Insect Cells

1991 • 810 citations

Cell Growth Arrest and Induction of Cyclin-Dependent Kinase Inhibitor p21 ^WAF1/CIP1 Mediated by STAT1

1996 • 796 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase

1990 • 783 citations

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1992 • 766 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

Inactivation of Bcl-2 by phosphorylation.

1995 • 744 citations

Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2

1997 • 742 citations

Induction of apoptosis by the Bcl-2 homologue Bak

1995 • 738 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

Apoptosis in Human Atherosclerosis and Restenosis

1995 • 684 citations

A License to Kill

1996 • 649 citations

Inhibition of ICE Family Proteases by Baculovirus Antiapoptotic Protein p35

1995 • 645 citations

Programmed cell death and Bcl-2 protection in very low oxygen

1995 • 638 citations

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

1997 • 635 citations

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

1995 • 616 citations

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.

1994 • 605 citations

Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death.

1993 • 602 citations

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

1994 • 590 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

1992 • 588 citations

Lamin proteolysis facilitates nuclear events during apoptosis.

1996 • 587 citations

The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis

1993 • 586 citations

Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer

1994 • 567 citations

RAIDD is a new 'death' adaptor molecule

1997 • 547 citations

The CARD domain: a new apoptotic signalling motif

1997 • 532 citations

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.

1995 • 524 citations

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

1995 • 514 citations

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

1995 • 501 citations

A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

1995 • 491 citations

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

1993 • 488 citations

Evidence for apoptosis in human atherogenesis and in a rat vascular injury model.

1995 • 484 citations

CPP32/Apopain Is a Key Interleukin 1β Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis

1996 • 480 citations

Proapoptotic Protein Bax Heterodimerizes with Bcl-2 and Homodimerizes with Bax via a Novel Domain (BH3) Distinct from BH1 and BH2

1996 • 462 citations

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis.

1993 • 452 citations

Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.

1995 • 431 citations

Induction of apoptosis by the transcription factor c-Jun

1997 • 421 citations

Bcl-2 Undergoes Phosphorylation by c-Jun N-terminal Kinase/Stress-activated Protein Kinases in the Presence of the Constitutively Active GTP-binding Protein Rac1

1997 • 406 citations

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-XL

1997 • 381 citations

Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells

1997 • 367 citations

The Baculovirus p35 Protein Inhibits Fas- and Tumor Necrosis Factor-induced Apoptosis

1995 • 366 citations

Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation

1990 • 364 citations

The 19-Kilodalton Adenovirus E1B Transforming Protein Inhibits Programmed Cell Death and Prevents Cytolysis by Tumor Necrosis Factor α

1992 • 354 citations

Activation of cyclin A-dependent protein kinases during apoptosis.

1994 • 352 citations

The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein.

1996 • 346 citations

Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase.

1994 • 345 citations

Interaction and Regulation of Subcellular Localization of CED-4 by CED-9

1997 • 345 citations

Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2.

1993 • 336 citations

Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.

1996 • 335 citations

Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.

1995 • 321 citations

Interaction between the C. elegans cell-death regulators CED-9 and CED-4

1997 • 304 citations

Angiotensin Type 2 Receptor Dephosphorylates Bcl-2 by Activating Mitogen-activated Protein Kinase Phosphatase-1 and Induces Apoptosis

1997 • 301 citations

Identification of a novel regulatory domain in Bcl-xL and Bcl-2

1997 • 287 citations

Bcl-2 expression prevents activation of the ICE protease cascade.

1996 • 254 citations

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.

1997 • 252 citations

Mcl-1, a member of the Bcl-2 family, delays apoptosis induced by c-Myc overexpression in Chinese hamster ovary cells.

1994 • 249 citations

Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.

1996 • 247 citations

Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities.

1996 • 236 citations

Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase.

1994 • 233 citations

Apoptosis induced by HIV-1 infection of the central nervous system.

1996 • 230 citations

Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis

1997 • 211 citations

Cleavage of retinoblastoma protein during apoptosis: an interleukin 1 beta-converting enzyme-like protease as candidate.

1996 • 204 citations

Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2.

1996 • 195 citations

An African swine fever virus gene with similarity to the proto-oncogene bcl-2 and the Epstein-Barr virus gene BHRF1

1993 • 194 citations

Tyrosine kinase activation provides an early and requisite signal for Fas-induced apoptosis.

1994 • 184 citations

Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining.

1992 • 171 citations

Degradation of Retinoblastoma Protein in Tumor Necrosis Factor- and CD95-induced Cell Death

1997 • 170 citations

Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced

1997 • 168 citations

Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes

1996 • 166 citations

Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing

1992 • 165 citations

Bcl-2 protein expression during murine development.

1994 • 164 citations

Diphtheria toxin: membrane interaction and membrane translocation

1992 • 154 citations

Cytoplasmic truncation of the p55 tumour necrosis factor (TNF) receptor abolishes signalling, but not induced shedding of the receptor.

1992 • 152 citations

Programmed cell death by bcl-2-dependent and independent mechanisms in B lymphoma cells.

1993 • 147 citations

P1 Aspartate-Based Peptide .alpha.-((2,6-Dichlorobenzoyl)oxy)methyl Ketones as Potent Time-Dependent Inhibitors of Interleukin-1.beta.-Converting Enzyme

1994 • 147 citations

A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow.

1995 • 147 citations

Bcl-2 and adenovirus E1B 19 kDA protein prevent E1A-induced processing of CPP32 and cleavage of poly(ADP-ribose) polymerase.

1996 • 144 citations

Growth- and tumor-promoting effects of deregulated BCL2 in human B-lymphoblastoid cells.

1989 • 138 citations

Interaction and Regulation of the Caenorhabditis elegans Death Protease CED-3 by CED-4 and CED-9

1997 • 130 citations

Suppression of Interleukin-1β-converting Enzyme-mediated Cell Death by Insulin-like Growth Factor

1996 • 121 citations

CED-4 induces chromatin condensation in Schizosaccharomyces pombe and is inhibited by direct physical association with CED-9

1997 • 120 citations

A Peptide Sequence from Bax That Converts Bcl-2 into an Activator of Apoptosis

1996 • 111 citations

bfl-1, a bcl-2 homologue, suppresses p53-induced apoptosis and exhibits potent cooperative transforming activity.

1996 • 109 citations

Affinity labeling displays the stepwise activation of ICE-related proteases by Fas, staurosporine, and CrmA-sensitive caspase-8

1997 • 107 citations

Apoptosis: Bcl-2-related proteins get connected

1997 • 100 citations

Mechanism of the inhibition of Ca2+, Mg2+-dependent endonuclease of bull seminal plasma induced by ADP-ribosylation.

1984 • 97 citations

Involvement of caspase-4(-like) protease in Fas-mediated apoptotic pathway

1997 • 97 citations

Baculovirus inhibitor of apoptosis functions at or upstream of the apoptotic suppressor P35 to prevent programmed cell death

1997 • 94 citations

Cytokine triggered molecular pathways that control cell cycle arrest

1992 • 89 citations

T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection

1997 • 88 citations

Nuclear lamin proteins: domains required for nuclear targeting, assembly, and cell-cycle-regulated dynamics

1991 • 79 citations

p21-activated kinase has substrate specificity similar to Acanthamoeba myosin I heavy chain kinase and activates Acanthamoeba myosin I

1997 • 79 citations

Role of apoptosis in HIV disease pathogenesis

1995 • 79 citations

Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding

1997 • 79 citations

The molecular basis of E2F-1/DP-1-induced S-phase entry and apoptosis.

1996 • 56 citations

Inhibitors of epidermal growth factor receptor kinase and of cyclin-dependent kinase 2 activation induce growth arrest, differentiation, and apoptosis of human papilloma virus 16-immortalized human keratinocytes.

1997 • 53 citations

Fas stimulation induces RB dephosphorylation and proteolysis that is blocked by inhibitors of the ICE protease family

1997 • 47 citations

Complementation by BCL2 and C-HA-RAS Oncogenes in Malignant Transformation of Rat Embryo Fibroblasts

1990 • 42 citations

The Large Subunit of the DNA Replication Complex C (DSEB/RF-C140) Cleaved and Inactivated by Caspase-3 (CPP32/YAMA) during Fas-induced Apoptosis

1997 • 37 citations

Failure to activate interleukin 1β‐converting enzyme‐like proteases and to cleave retinoblastoma protein in drug‐resistant cells

1996 • 22 citations