Characterization of Non-peptide Antagonist and Peptide Agonist Binding Sites of the NK1 Receptor with Fluorescent Ligands

Principles of Fluorescence Spectroscopy

1999 • 27,045 citations

Neurotransmitter functions of mammalian tachykinins.

1993 • 1,101 citations

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

1991 • 875 citations

Locating ligand-binding sites in 7tm receptors by protein engineering

1994 • 282 citations

Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P (NK ₁ ) Receptor Antagonist

1991 • 221 citations

Discovery of a potent substance P antagonist: recognition of the key molecular determinant

1992 • 220 citations

Different binding epitopes on the NK1 receptor for substance P and a non-peptide antagonist

1993 • 213 citations

Localization of agonist and antagonist binding domains of the human neurokinin-1 receptor.

1992 • 190 citations

Amino–aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345

1993 • 185 citations

Interaction of Substance P with the Second and Seventh Transmembrane Domains of the Neurokinin-1 Receptor

1994 • 136 citations

Probing the Structure and Function of the Tachykinin Neurokinin-2 Receptor through Biosynthetic Incorporation of Fluorescent Amino Acids at Specific Sites

1996 • 133 citations

The extracellular domain of the neurokinin-1 receptor is required for high-affinity binding of peptides

1992 • 118 citations

The discovery of (2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine as a novel, nonpeptide substance P antagonist

1992 • 108 citations

Mutations along transmembrane segment II of the NK-1 receptor affect substance P competition with non-peptide antagonists but not substance P binding.

1994 • 105 citations

Thrombin Receptor Activating Mutations

1996 • 102 citations

Chimeric NK1 (substance P)/NK3 (neurokinin B) receptors. Identification of domains determining the binding specificity of tachykinin agonists.

1993 • 99 citations

The Tachykinin Receptors

1994 • 99 citations

High‐level Expression of the Human Neurokinin‐1 Receptor in Mammalian Cell Lines using the Semliki Forest Virus Expression System

1994 • 98 citations

Characterization of the binding domain of the beta-adrenergic receptor with the fluorescent antagonist carazolol. Evidence for a buried ligand binding site.

1990 • 97 citations

Extracellular Domains of the Bradykinin B2 Receptor Involved in Ligand Binding and Agonist Sensing Defined by Anti-peptide Antibodies

1996 • 93 citations

Molecular Mechanism of Action of Non-peptide Ligands for Peptide Receptors

1995 • 78 citations

Fluorescence Polarization

1983 • 71 citations

Mapping Peptide-binding Domains of the Substance P (NK-1) Receptor from P388D 1 Cells with Photolabile Agonists

1995 • 71 citations

Luminescence quenching by nitroxide spin labels in aqueous solution: studies on the mechanism of quenching

1992 • 71 citations

The peptide binding site of the substance P (NK-1) receptor localized by a photoreactive analogue of substance P: presence of a disulfide bond.

1996 • 62 citations

The Use of Photolabelled Peptides to Localize the Substance‐P‐Binding Site in the Human Neurokinin‐1 Tachykinin Receptor

1996 • 60 citations

Probing the Binding Domain of the NK2 Receptor with Fluorescent Ligands: Evidence That Heptapeptide Agonists and Antagonists Bind Differently

1995 • 47 citations

Specific residues at the top of transmembrane segment V and VI of the neurokinin-1 receptor involved in binding of the nonpeptide antagonist CP 96,345 [corrected]

1994 • 42 citations

A fluorescence-based detergent binding assay for protein hydrophobicity

1986 • 36 citations

Interaction of [fluorescein-Trp25]Glucagon with the Human Glucagon Receptor Expressed in Drosophila Schneider 2 Cells

1995 • 35 citations

Conserved His^VI‐17 of the NK‐1 receptor is involved in binding of non‐peptide antagonists but not substance P

1993 • 34 citations

Characterization of a Fluorescent Substance P Analog

1994 • 27 citations

Synthesis and Characterization of Selective Fluorescent Ligands for the neurokinin NK2 Receptor

1994 • 25 citations

Evidence for protonation in the human neutrophil formyl peptide receptor binding pocket

1993 • 22 citations

Transformation of methionine into S-tert-butylhomocysteine. Application to a methionine-containing peptide: substance P

1983 • 15 citations

Substituent control of intramolecular hydrogen bonding in formyl-protonated o-anisaldehydes: a stable ion and semiempirical MO investigation

1993 • 15 citations

Photoaffinity labeling of the human substance P (neurokinin-1) receptor with [3H2]azido-CP-96,345, a photoreactive derivative of a nonpeptide antagonist.

1996 • 13 citations

Antibody-Induced Conformational Changes in the Torpedo Nicotinic Acetylcholine Receptor: A Fluorescence Study

1994 • 12 citations

Biochemical Characterization and Solubilization of Human NK₂Receptor Expressed in Chinese Hamster Ovary Cells

1993 • 10 citations

The accessibility of peptides bound to the mouse MHC class II molecule IE^d studied by fluorescence

1994 • 2 citations