Characterization of the binding domain of the beta-adrenergic receptor with the fluorescent antagonist carazolol. Evidence for a buried ligand binding site.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY

1963 • 10,322 citations

Zwischenmolekulare Energiewanderung und Fluoreszenz

1948 • 7,839 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Photophysics of aromatic molecules

1971 • 4,490 citations

Fluorescence Energy Transfer as a Spectroscopic Ruler

1978 • 2,370 citations

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

1986 • 1,264 citations

Principles of fluorescence spectroscopy

1984 • 1,031 citations

Exposure of tryptophanyl residues in proteins. Quantitative determination by fluorescence quenching studies

1976 • 1,020 citations

Glutamic acid-113 serves as the retinylidene Schiff base counterion in bovine rhodopsin.

1989 • 663 citations

Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function.

1988 • 533 citations

Identification of Two Serine Residues Involved in Agonist Activation of the β-Adrenergic Receptor

1989 • 522 citations

Structural basis of β‐adrenergic receptor function

1989 • 480 citations

Identification of residues required for ligand binding to the beta-adrenergic receptor.

1987 • 398 citations

Structural features required for ligand binding to the beta-adrenergic receptor.

1987 • 358 citations

Ligand binding to the β-adrenergic receptor involves its rhodopsin-like core

1987 • 318 citations

Regression analysis of nonlinear Arrhenius plots: An empirical model and a computer program

1984 • 313 citations

The opsin family of proteins

1986 • 245 citations

Fluorescence energy transfer in the rapid-diffusion limit

1978 • 165 citations

Affinity chromatography of the beta-adrenergic receptor.

1979 • 156 citations

Dynamics of a protein matrix revealed by fluorescence quenching.

1975 • 154 citations

International union of pure and applied chemistry organic chemistry division commission on photochemistry

1988 • 153 citations

Penetration of small molecules into proteins studied by quenching of phosphorescence and fluorescence

1983 • 135 citations

Identification and sequence of a binding site peptide of the .beta.2-adrenergic receptor

1988 • 128 citations

Site-directed Anti-peptide Antibodies Define the Topography of the β-Adrenergic Receptor

1989 • 127 citations

Rhodopsin's protein and carbohydrate structure: Selected aspects

1984 • 124 citations

The catecholamine binding site of the beta-adrenergic receptor is formed by juxtaposed membrane-spanning domains.

1988 • 121 citations

Transverse location of the retinal chromophore of rhodopsin in rod outer segment disc membranes

1982 • 96 citations

Protein fluorescence quenching by small molecules: Protein penetration versus solvent exposure

1986 • 70 citations

Reconstitution of the purified porcine atrial muscarinic acetylcholine receptor with purified porcine atrial inhibitory guanine nucleotide binding protein

1987 • 63 citations

High-efficiency expression of mammalian β-adrenergic receptors in baculovirus-infected insect cells

1989 • 62 citations

Carazolol, an extremely potent β-adrenergic blocker: Binding to β-receptors in brain membranes

1979 • 55 citations

Cytoplasmic loop of β-adrenergic receptors: synaptic and intracellular localization and relation to catecholaminergic neurons in the nuclei of the solitary tracts

1989 • 54 citations

Transfert d’énergie dans les liquides aromatiques

1966 • 54 citations

Energy transfer in organic systems VII. Effect of diffusion on fluorescence decay

1968 • 47 citations

A rhodopsin pigment containing a spin-labeled retinal

1987 • 38 citations

Molecular structure and evolution of adrenergic and cholinergic receptors

1986 • 25 citations

A molecular graphics study exploring a putative ligand binding site of theβ-adrenoceptor

1988 • 10 citations

Lack of interaction of rhodopsin chromophore with membrane lipids. An electron-electron double resonance study using 14N:15N pairs

1988 • 9 citations