Chimeric NK1 (substance P)/NK3 (neurokinin B) receptors. Identification of domains determining the binding specificity of tachykinin agonists.

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

Chimeric α ₂ -,β ₂ -Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity

1988 • 766 citations

cDNA eloping of bovine substance-K receptor through oocyte expression system

1987 • 748 citations

Isolation of a Sialogogic Peptide from Bovine Hypothalamic Tissue and Its Characterization as Substance P

1970 • 689 citations

Tachykinins

1988 • 542 citations

Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function.

1988 • 533 citations

Mammalian Tachykinin Receptors

1991 • 502 citations

Molecular characterization of a functional cDNA for rat substance P receptor

1989 • 463 citations

New selective agonists for neurokinin receptors: pharmacological tools for receptor characterization

1988 • 360 citations

Ligand binding to the β-adrenergic receptor involves its rhodopsin-like core

1987 • 318 citations

Highly selective agonists for substance P receptor subtypes.

1986 • 316 citations

Cloning and expression of a rat neuromedin K receptor cDNA.

1990 • 308 citations

Calculating receptor number from binding experiments using same compound as radioligand and competitor

1989 • 250 citations

Substance P precursor and kininogen: their structures, gene organizations, and regulation

1987 • 241 citations

Extracellular domain of lutropin/choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity.

1990 • 237 citations

Localization of agonist and antagonist binding domains of the human neurokinin-1 receptor.

1992 • 190 citations

Thyrotropin-luteinizing hormone/chorionic gonadotropin receptor extracellular domain chimeras as probes for thyrotropin receptor function.

1991 • 183 citations

The tachykinins: a family of peptides with a brood of ‘receptors’

1986 • 164 citations

Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors.

1988 • 160 citations

Biosynthesis of peptide precursors and protease inhibitors using new constitutive and inducible eukaryotic expression vectors

1990 • 160 citations

Site-directed mutagenesis of the m3 muscarinic receptor: identification of a series of threonine and tyrosine residues involved in agonist but not antagonist binding.

1991 • 152 citations

Immunomodulation by Tachykinin Neuropeptidesa

1990 • 126 citations

Determination of the amino acid residues in substance P conferring selectivity and specificity for the rat neurokinin receptors.

1992 • 121 citations

Demonstration of two distinct tachykinin receptors in rat brain cortex.

1985 • 100 citations

Delineation of structural domains involved in the subtype specificity of tachykinin receptors through chimeric formation of substance P/substance K receptors.

1992 • 97 citations

Nonpeptide antagonists herald new era in tachykinin research

1992 • 85 citations

Selective binding of ligands to beta 1, beta 2 or chimeric beta 1/beta 2-adrenergic receptors involves multiple subsites.

1990 • 76 citations

Characterization of ligand-binding properties and selectivities of three rat tachykinin receptors by transfection and functional expression of their cloned cDNAs in mammalian cells.

1991 • 75 citations

Stable expression of high affinity NK₁ (substance P) and NK₂(neurokinin A) receptors but low affinity NK₃ (neurokinin B) receptors in transfected CHO cells

1992 • 34 citations

The extracellular domain of substance P (NK1) receptor comprises part of the ligand binding site

1992 • 16 citations

C-terminal KDEL-modified cystatin C is retained in transfected CHO cells

1990 • 11 citations

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