The Use of Photolabelled Peptides to Localize the Substance‐P‐Binding Site in the Human Neurokinin‐1 Tachykinin Receptor

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii

2007 • 11,720 citations

Methods in Molecular Biology

2008 • 1,605 citations

Benzophenone Photophores in Biochemistry

1994 • 835 citations

Recent Trends in Photoaffinity Labeling

1995 • 386 citations

Different binding epitopes on the NK1 receptor for substance P and a non-peptide antagonist

1993 • 213 citations

Localization of agonist and antagonist binding domains of the human neurokinin-1 receptor.

1992 • 190 citations

Amino–aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345

1993 • 185 citations

Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580.

1992 • 175 citations

Interaction of Substance P with the Second and Seventh Transmembrane Domains of the Neurokinin-1 Receptor

1994 • 136 citations

The extracellular domain of the neurokinin-1 receptor is required for high-affinity binding of peptides

1992 • 118 citations

Molecular basis for the species selectivity of the substance P antagonist CP-96,345.

1993 • 118 citations

Tachykinin peptides affect differently the second messenger pathways after binding to CHO-expressed human NK-1 receptors.

1996 • 105 citations

Mutations along transmembrane segment II of the NK-1 receptor affect substance P competition with non-peptide antagonists but not substance P binding.

1994 • 105 citations

Proteolytic activity of pseudotrypsin

1971 • 104 citations

Chimeric NK1 (substance P)/NK3 (neurokinin B) receptors. Identification of domains determining the binding specificity of tachykinin agonists.

1993 • 99 citations

Design and Synthesis of Side-Chain Conformationally Restricted Phenylalanines and Their Use for Structure-Activity Studies on Tachykinin NK-1 Receptor

1994 • 73 citations

Mapping Peptide-binding Domains of the Substance P (NK-1) Receptor from P388D 1 Cells with Photolabile Agonists

1995 • 71 citations

Two nonpeptide tachykinin antagonists act through epitopes on corresponding segments of the NK1 and NK2 receptors.

1993 • 69 citations

Asymmetric synthesis of L-diphenylalanine and L-9-fluorenylglycine via room temperature alkylations of a sultam-derived glycine imine

1991 • 66 citations

Coupling of MALDI-TOF Mass Analysis to the Separation of Biotinylated Peptides by Magnetic Streptavidin Beads

1996 • 65 citations

The peptide binding site of the substance P (NK-1) receptor localized by a photoreactive analogue of substance P: presence of a disulfide bond.

1996 • 62 citations

The Nonpeptide NK-2 Antagonist SR 48968 Is Also a NK-3 Antagonist in the Guinea Pig but Not in the Rat

1993 • 51 citations

The species selectivity of chemically distinct tachykinin nonpeptide antagonists is dependent on common divergent residues of the rat and human neurokinin-1 receptors.

1994 • 48 citations

Specific residues at the top of transmembrane segment V and VI of the neurokinin-1 receptor involved in binding of the nonpeptide antagonist CP 96,345 [corrected]

1994 • 42 citations

Localization of the ligand binding site of the neurokinin-1 receptor: interpretation of chimeric mutations and single-residue substitutions.

1994 • 36 citations

Functional nonequivalence of structurally homologous domains of neurokinin-1 and neurokinin-2 type tachykinin receptors

1993 • 34 citations

Specific recognition of SP or NKB receptors by analogues of SP substituted at positions 8 and 9

1986 • 28 citations

Evidence for a common molecular mode of action for chemically distinct nonpeptide antagonists at the neurokinin-1 (substance P) receptor.

1994 • 26 citations

Characterization of the Substance P (NK‐1) Receptor in Tunicamycin‐Treated Transfected Cells Using a Photoaffinity Analogue of Substance P

1995 • 23 citations

Identification of the Site in the Substance P (NK-1) Receptor for Modulation of Peptide Binding by Sulfhydryl Reagents

1996 • 12 citations