Thrombin Receptor Activating Mutations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function

1993 • 873 citations

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1993 • 769 citations

A Constitutively Active Mutant PTH-PTHrP Receptor in Jansen-Type Metaphyseal Chondrodysplasia

1995 • 668 citations

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

1987 • 609 citations

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.

1992 • 587 citations

Congenital Hyperthyroidism Caused by a Mutation in the Thyrotropin-Receptor Gene

1995 • 309 citations

Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases.

1994 • 218 citations

Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface

1994 • 210 citations

Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling

1993 • 205 citations

Pertussis toxin inhibits thrombin-induced activation of phosphoinositide hydrolysis and Na+/H+ exchange in hamster fibroblasts.

1986 • 165 citations

Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor.

1992 • 146 citations

Identification and functional characterization of two new somatic mutations causing constitutive activation of the thyrotropin receptor in hyperfunctioning autonomous adenomas of the thyroid.

1994 • 128 citations

Expanding horizons for receptors coupled to G proteins: diversity and disease

1994 • 127 citations

Abnormalities in G protein-coupled signal transduction pathways in human disease.

1993 • 118 citations

Mechanisms of Thrombin Receptor Agonist Specificity

1995 • 118 citations

Novel mutations of thyrotropin receptor gene in thyroid hyperfunctioning adenomas. Rapid identification by fine needle aspiration biopsy.

1994 • 116 citations

Binding of NCK to SOS and Activation of ras-Dependent Gene Expression

1995 • 94 citations

Expression of receptors for cholecystokinin and other Ca2+-mobilizing hormones in Xenopus oocytes.

1988 • 68 citations