The KRN mouse model of inflammatory arthritis

Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation

1998 • 5,369 citations

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

1998 • 4,184 citations

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

1999 • 3,340 citations

Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis

2000 • 2,992 citations

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

1997 • 2,257 citations

A Trial of Etanercept, a Recombinant Tumor Necrosis Factor Receptor:Fc Fusion Protein, in Patients with Rheumatoid Arthritis Receiving Methotrexate

1999 • 2,117 citations

HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation

2003 • 1,909 citations

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

1999 • 1,832 citations

IgG Fc Receptors

2001 • 1,667 citations

INHIBITORY EFFECT OF TNF$alpha; ANTIBODIES ON SYNOVIAL CELL INTERLEUKIN-1 PRODUCTION IN RHEUMATOID ARTHRITIS

1989 • 1,137 citations

Organ-Specific Disease Provoked by Systemic Autoimmunity

1996 • 880 citations

TRANCE (Tumor Necrosis Factor [TNF]-related Activation-induced Cytokine), a New TNF Family Member Predominantly Expressed in T cells, Is a Dendritic Cell–specific Survival Factor

1997 • 869 citations

Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

1999 • 824 citations

Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor

2000 • 811 citations

TRANCE/RANKL Knockout Mice Are Protected from Bone Erosion in a Serum Transfer Model of Arthritis

2001 • 803 citations

Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis

2002 • 764 citations

Arthritis Critically Dependent on Innate Immune System Players

2002 • 694 citations

From Systemic T Cell Self-Reactivity to Organ-Specific Autoimmune Disease via Immunoglobulins

1999 • 689 citations

Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin‐1 receptor antagonist, in combination with methotrexate: Results of a twenty‐four–week, multicenter, randomized, double‐blind, placebo‐controlled trial

2002 • 629 citations

Arthritis Provoked by Linked T and B Cell Recognition of a Glycolytic Enzyme

1999 • 620 citations

Essential Role of Neutrophils in the Initiation and Progression of a Murine Model of Rheumatoid Arthritis

2001 • 583 citations

Induction of arthritis with monoclonal antibodies to collagen.

1992 • 382 citations

The C5a chemoattractant receptor mediates mucosal defence to infection

1996 • 345 citations

How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease

2002 • 334 citations

Critical Roles for Interleukin 1 and Tumor Necrosis Factor α in Antibody-induced Arthritis

2002 • 327 citations

Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals progression of erosions despite clinical improvement

1999 • 312 citations

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

1999 • 290 citations

Chondroclasts and osteoclasts at subchondral sites of erosion in the rheumatoid joint

1984 • 286 citations

Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment

1994 • 251 citations

Clinical improvement and radiological deterioration in rheumatoid arthritis: evidence that the pathogenesis of synovial inflammation and articular erosion may differ

1996 • 231 citations

Arthritogenic Monoclonal Antibodies from K/BxN Mice

2002 • 229 citations

Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease

2001 • 212 citations

The effect of an interleukin‐1 receptor antagonist protein on type ii collagen–induced arthritis and antigen‐induced arthritis in mice

1993 • 204 citations

Interleukin 1 Receptor Dependence of Serum Transferred Arthritis Can be Circumvented by Toll-like Receptor 4 Signaling

2003 • 190 citations

The type I interleukin‐1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF‐transgenic mice

1995 • 159 citations

Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction.

1998 • 149 citations

Genetic Influences on the End-Stage Effector Phase of Arthritis

2001 • 149 citations

Involvement of Fcγ receptor IIIA genotypes in susceptibility to rheumatoid arthritis

2000 • 123 citations

Dynamic visualization of a joint-specific autoimmune response through positron emission tomography

2002 • 123 citations

Does properdin crosslink the cellular and the humoral immune response?

1999 • 118 citations

Molecular Basis for Recognition of an Arthritic Peptide and a Foreign Epitope on Distinct MHC Molecules by a Single TCR

2000 • 81 citations

HIF-1alpha is essential for myeloid cell-mediated inflammation

2003 • 69 citations

Delineation of antigen contact residues on an MHC class II molecule.

1990 • 66 citations

The role of CD40 ligand and tumor necrosis factor α signaling in the transgenic K/BxN mouse model of rheumatoid arthritis

2000 • 63 citations

The arthritogenic T cell receptor and its ligand in a model of spontaneous arthritis

1999 • 60 citations

Transmission of antibody-induced arthritis is independent of complement component 4 (C4) and the complement receptors 1 and 2 (CD21/35)

2002 • 46 citations

Genetic studies, clinical heterogeneity, and disease outcome studies in rheumatoid arthritis

2002 • 19 citations