The role of CD40 ligand and tumor necrosis factor α signaling in the transgenic K/BxN mouse model of rheumatoid arthritis

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

1996 • 2,527 citations

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

1999 • 1,832 citations

Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)–Fc Fusion Protein

1997 • 1,651 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

1998 • 1,546 citations

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

1999 • 1,325 citations

Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α

1993 • 1,031 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

FcR γ chain deletion results in pleiotrophic effector cell defects

1994 • 967 citations

Organ-Specific Disease Provoked by Systemic Autoimmunity

1996 • 880 citations

Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

1999 • 824 citations

TNF Receptor-Deficient Mice Reveal Divergent Roles for p55 and p75 in Several Models of Inflammation

1998 • 715 citations

Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

1991 • 694 citations

From Systemic T Cell Self-Reactivity to Organ-Specific Autoimmune Disease via Immunoglobulins

1999 • 689 citations

Uncoupling of Immune Complex Formation and Kidney Damage in Autoimmune Glomerulonephritis

1998 • 621 citations

Arthritis Provoked by Linked T and B Cell Recognition of a Glycolytic Enzyme

1999 • 620 citations

How important are t cells in chronic rheumatoid synovitis?

1990 • 553 citations

Humoral immune responses in CD40 ligand-deficient mice.

1994 • 541 citations

Induction of self-tolerance in mature peripheral B lymphocytes

1989 • 525 citations

Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: A comparative study using anti-TNFα, anti-IL-1α/β and IL-1Ra

2008 • 514 citations

IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation.

1999 • 449 citations

B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40

1993 • 390 citations

Anticytokine treatment of established type II collagen–induced arthritis in DBA/1 mice: A comparative study using anti‐TNFα, anti–IL‐1α/β, and IL‐1Ra

1996 • 370 citations

IL-1αβ Blockade Prevents Cartilage and Bone Destruction in Murine Type II Collagen-Induced Arthritis, Whereas TNF-α Blockade Only Ameliorates Joint Inflammation

1999 • 363 citations

Peripheral deletion of self-reactive B cells

1991 • 353 citations

The many roles of CD40 in cell-mediated inflammatory responses

1996 • 276 citations

Cytotoxic antibodies trigger inflammation through Fc receptors

1995 • 263 citations

Pannus and pannocytes

1994 • 224 citations

Hypercross-linking surface IgM or IgD receptors on mature B cells induces apoptosis that is reversed by costimulation with IL-4 and anti-CD40.

1994 • 210 citations

Transmembrane TNF is sufficient to induce localized tissue toxicity and chronic inflammatory arthritis in transgenic mice.

1996 • 121 citations

Major role for interleukin 1 but not for tumor necrosis factor in early cartilage damage in immune complex arthritis in mice.

1995 • 87 citations

Animal models of rheumatoid arthritis

1999 • 79 citations

Transfusion studies in rheumatoid arthritis

1961 • 65 citations

Animal models in rheumatoid arthritis

1995 • 62 citations

The arthritogenic T cell receptor and its ligand in a model of spontaneous arthritis

1999 • 60 citations

Functional analysis of rheumatoid factor-producing B cells from the synovial fluid of rheumatoid arthritis patients

1998 • 58 citations

Human Rheumatoid Factor Production Is Dependent on CD40 Signaling and Autoantigen

1999 • 56 citations

Ligation of CD40 induced tumor necrosis factor-alpha in rheumatoid arthritis: a novel mechanism of activation of synoviocytes.

1999 • 45 citations

Expression and function of CD40 in rheumatoid arthritis synovium.

1998 • 30 citations

Anti-inflammatory effects of systemic anti-tumour necrosis factor alpha treatment in human/murine SCID arthritis

1999 • 10 citations