Extraneuronal cholinergic system in lymphocytes

Inositol phosphates and cell signalling

1989 • 4,058 citations

Development of a Strain of Spontaneously Hypertensive Rats

1963 • 2,492 citations

Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores

1989 • 1,616 citations

Identification of a Family of Muscarinic Acetylcholine Receptor Genes

1987 • 1,439 citations

Muscarinic Receptor Subtypes

1990 • 1,346 citations

T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes

1982 • 1,026 citations

Photochemically generated cytosolic calcium pulses and their detection by fluo-3

1989 • 820 citations

The Cholinesterases: From Genes to Proteins

1994 • 650 citations

Nuclear factor of activated T cells contains Fos and Jun

1992 • 495 citations

Choline esters in tissue extracts

1933 • 490 citations

Cholinergic Mechanisms and Psychopharmacology

1978 • 437 citations

Acetylcholine and Choline in Neuronal Tissue Measured by HPLC with Electrochemical Detection

1983 • 413 citations

Vesicular acetylcholine transporter (VAChT) protein: A novel and unique marker for cholinergic neurons in the central and peripheral nervous systems

1997 • 409 citations

Non-neuronal acetylcholine, a locally acting molecule, widely distributed in biological systems: Expression and function in humans

1998 • 407 citations

Functional identification of a vesicular acetylcholine transporter and its expression from a “cholinergic” gene locus.

1994 • 383 citations

Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells

1994 • 377 citations

THE CHOLINERGIC ‘PITFALL’: ACETYLCHOLINE, A UNIVERSAL CELL MOLECULE IN BIOLOGICAL SYSTEMS, INCLUDING HUMANS

1999 • 292 citations

Development of a Fluorescent Indicator for Nitric Oxide Based on the Fluorescein Chromophore.

1998 • 284 citations

Expression of the putative vesicular acetylcholine transporter in rat brain and localization in cholinergic synaptic vesicles

1996 • 283 citations

Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines

1999 • 235 citations

Guanosine 3′:5′-Cyclic Monophosphate and the Action of Insulin and Acetylcholine

1973 • 232 citations

The presence of histamine and acetylcholine in the spleen of the ox and the horse

1929 • 225 citations

Lymphocyte Hormone Receptors

1987 • 216 citations

Cholinergic systems in non-nervous tissues.

1978 • 206 citations

Cholera toxin inhibits the T-cell antigen receptor-mediated increases in inositol trisphosphate and cytoplasmic free calcium.

1986 • 202 citations

Molecular cloning of a putative vesicular transporter for acetylcholine.

1994 • 183 citations

A unique gene organization for two cholinergic markers, choline acetyltransferase and a putative vesicular transporter of acetylcholine.

1994 • 179 citations

THE MODULATING INFLUENCE OF CYCLIC NUCLEOTIDES UPON LYMPHOCYTE-MEDIATED CYTOTOXICITY

1973 • 174 citations

The synthesis of acetylcholine in skeletal muscles of the rat

1982 • 166 citations

Coordinated Up-regulation of Choline Acetyltransferase and Vesicular Acetylcholine Transporter Gene Expression by the Retinoic Acid Receptor α, cAMP, and Leukemia Inhibitory Factor/Ciliary Neurotrophic Factor Signaling Pathways in a Murine Septal Cell Line

1995 • 163 citations

Neuroreceptor changes in Alzheimer disease.

1992 • 161 citations

Evidence for the Regulation of Phytochrome-mediated Processes in Bean Roots by the Neurohumor, Acetylcholine

1970 • 160 citations

Molecular biology of the vesicular ACh transporter

1995 • 151 citations

Alteration of the Cytotoxic Action of Sensitized Lymphocytes by Cholinergic Agents and Activators of Adenylate Cyclase

1972 • 143 citations

Expression of acetylcholine receptor genes in human thymic epithelial cells: implications for myasthenia gravis.

1996 • 139 citations

Coregulation of Two Embedded Gene Products, Choline Acetyltransferase and the Vesicular Acetylcholine Transporter

1995 • 133 citations

Nicotinic acetylcholine receptor: evidence for a functionally distinct receptor on human lymphocytes.

1979 • 125 citations

Differential regulation of IFN‐γ, IL‐10 and inducible nitric oxide synthase in human T cells by cyclic AMP‐dependent signal transduction pathway

1997 • 124 citations

Cholinergic Augmentation of Lymphocyte-Mediated Cytotoxicity. A Study of the Cholinergic Receptor of Cytotoxic T Lymphocytes

1974 • 122 citations

Alternative Splicing Leads to Two Cholinergic Proteins in Caenorhabditis elegans

1994 • 116 citations

Radioimmunoassay for acetylcholine in the rat brain

1980 • 108 citations

Rat lymphocytes produce and secrete acetylcholine in dependence of differentiation and activation

1998 • 107 citations

Localization and synthesis of acetylcholine in human leukemic T cell lines

1996 • 103 citations

Induction of choline acetyltransferase mRNA in human mononuclear leukocytes stimulated by phytohemagglutinin, a T-cell activator

1998 • 98 citations

The Modulation of Spontaneous and Anti-Ig-Stimulated Motility of Lymphocytes by Cyclic Nucleotides and Adrenergic and Cholinergic Agents

1975 • 96 citations

The Production of Acetylcholine by a Strain of Lactobacillus plantarum

1947 • 95 citations

Immunological depression in spontaneously hypertensive rats.

1980 • 95 citations

The parallel, time-dependent, bimodal change in lymphocyte cholinergic binding activity and cholinergic influence upon lymphocyte-mediated cytotoxicity after lymphocyte activation.

1981 • 93 citations

Synthesis and release of acetylcholine by cultured bovine arterial endothelial cells

1990 • 92 citations

Expression of inducible nitric oxide synthase in T lymphocytes and macrophages of cholesterol-fed rabbits

1997 • 92 citations

The occurrence of homologues of acetylcholine in ox spleen

1953 • 90 citations

Acetylcholine synthesis and muscarinic receptor subtype mRNA expression in T-lymphocytes

1998 • 89 citations

Expression of Three Alternative Acetylcholinesterase Messenger RNAs in Human Tumor Cell Lines of Different Tissue Origins

1994 • 88 citations

Mechanisms of human cell-mediated cytotoxicity. I. Modulation of natural killer cell activity by cyclic nucleotides.

1982 • 88 citations

Cholinergic receptors of lymphocytes

1989 • 84 citations

Acetylcholinesterase activity of lymphocytes: an enzyme characteristic of T‐cells

1982 • 84 citations

Choline Acetyltransferase and the Synthesis of Acetylcholine

1988 • 80 citations

Nitric oxide synthase: expression of the endothelial, Ca²⁺/calmodulin‐dependent isoform in human B and T lymphocytes

1996 • 79 citations

Immunocytochemical Detection of Acetylcholine in the Rat Central Nervous System

1985 • 78 citations

Detection of choline‐acetyltransferase activity in lymphocytes

1993 • 76 citations

Coordinate expression of vesicular acetylcholine transporter and choline acetyltransferase in sympathetic superior cervical neurones

1995 • 76 citations

Identification of nicotinic acetylcholine receptors on lymphocytes in the periphery as well as thymus in mice

1997 • 74 citations

Expression of nitric oxide synthase in human peripheral blood mononuclear cells and neutrophils.

1995 • 73 citations

Muscarinic cholinergic receptors in murine lymphocytes: demonstration by direct binding.

1978 • 73 citations

Expression of alpha subunit genes of nicotinic acetylcholine receptors in human lymphocytes

1996 • 72 citations

Effect of light on the acetylcholine concentrations of the suprachiasmatic nucleus in the rat

1984 • 62 citations

The identification of propionylcholine as a constituent of ox spleen

1954 • 61 citations

Muscarinic cholinergic binding sites on intact human lymphocytes

1981 • 61 citations

Human choline acetyltransferase mRNAs with different 5′-region produce a 69-kDa major translation product

1997 • 61 citations

Constitutive expression of mRNA for the same choline acetyltransferase as that in the nervous system, an acetylcholine-synthesizing enzyme, in human leukemic T-cell lines

1999 • 61 citations

Characterization of immunological depression in spontaneously hypertensive rats

1981 • 59 citations

Species differences in the concentration of acetylcholine, a neurotransmitter, in whole blood and plasma

1995 • 58 citations

Choline and acetylcholine: handbook of chemical assay methods,

1974 • 53 citations

Stimulatory Roles of Muscarinic Acetylcholine Receptors on T Cell Antigen Receptor/CD3 Complex-Mediated Interleukin-2 Production in Human Peripheral Blood Lymphocytes

1997 • 52 citations

The parasympathetic nervous system takes part in the immuno-neuroendocrine dialogue

1991 • 51 citations

Efficient coupling of m5 muscarinic acetylcholine receptors to activation of nitric oxide synthase.

1994 • 51 citations

Expression of Choline Acetyltransferase mRNA and Protein in T-Lymphocytes.

1995 • 50 citations

A cholinergic receptor site on murine lymphocytes with novel binding characteristics

1984 • 50 citations

Extraneuronal localization of acetylcholine and its release upon nicotinic stimulation in rabbits

1989 • 50 citations

Extraneural cholinergic markers in Alzheimer's and Parkinson's disease

1986 • 49 citations

Phorbol ester stimulates acetylcholine synthesis in cultured endothelial cells isolated from porcine cerebral microvessels

1994 • 49 citations

Changes in the cholinergic system of lymphocytes due to mitogenic stimulation

1987 • 48 citations

Determination of Acetylcholine and Choline in Rat Brain Tissue by Liquid Chromatography/Electrochemistry Using an Immobilized Enzyme Post Column Reactor

1986 • 47 citations

Natural cytotoxic autoantibody against thymocytes in spontaneously hypertensive rats

1981 • 46 citations

Cholinergic muscarinic binding by human lymphocytes: Changes with aging, antagonist treatment, and senile dementia of the Alzheimer type

1986 • 46 citations

Presence of m3 subtype muscarinic acetylcholine receptors and receptor-mediated increases in the cytoplasmic concentration of Ca2+ in Jurkat, a human leukemic helper T lymphocyte line.

1993 • 46 citations

Muscarinic cholinergic receptors on intact human lymphocytes properties and subclass characterization

1987 • 43 citations

Muscarinic receptor subtypes in subpopulations of human blood mononuclear cells as analyzed by RT-PCR technique

1996 • 43 citations

Expression of alpha-3, alpha-5, and beta-4 neuronal acetylcholine receptor subunit transcripts in normal and myasthenia gravis thymus. Identification of thymocytes expressing the alpha-3 transcripts.

1993 • 42 citations

Synthesis of acetylcholine by non-nervous tissue.

1946 • 42 citations

Muscarinic cholinergic binding sites on rat lymphocytes

1988 • 42 citations

A muscarinic receptor type in human lymphocytes: A comparison of 3H-QNB binding to intact lymphocytes and lysed lymphocyte membranes

1986 • 41 citations

Occurrence of light-dependent acetylcholine concentrations in higher plants

1974 • 41 citations

Acetylcholine receptors of rat lymphocytes

1980 • 40 citations

A Possible Role for Acetylcholine in the Dialogue between Thymocytes and Thymic Stroma

1999 • 40 citations

Identification of m3, m4 and m5 subtypes of muscarinic receptor mRNA in human blood mononuclear cells

1995 • 40 citations

Presence of acetylcholine in blood and its localization in circulating mononuclear leukocytes of humans

1993 • 40 citations

Determination of acetylcholine in human blood

1986 • 38 citations

THE PRESENCE OF ACETYLCHOLINE IN TRYPANOSOMA RHODESIENSE AND ITS ABSENCE FROM PLASMODIUM GALLINACEUM

1949 • 38 citations

Determination of picomole amounts of choline and acetylcholine in blood by gas chromatography-mass spectrometry equipped with a newly improved pyrolyzer

1982 • 37 citations

Plasma concentration of acetylcholine in young women

1987 • 37 citations

The synthesis of acetylcholine by plants

1981 • 36 citations

Evidence for the presence of immunoreactive acetylcholine receptors on human thymus cells

1984 • 36 citations

Cholinergic Stimulation Modulates Apoptosis and Differentiation of Murine Thymocytes via a Nicotinic Effect on Thymic Epithelium

1994 • 34 citations

Developmental age-dependent upregulation of choline acetyltransferase and vesicular acetylcholine transporter mRNA expression in neonatal rat septum by nerve growth factor

1996 • 33 citations

Response of lymphocyte guanyl cyclase to propranolol, noradrenaline, thymoxamine, and acetylcholine in extrinsic bronchial asthma.

1975 • 32 citations

Expression of muscarinic cholinergic receptors during T cell maturation in the thymus

1987 • 30 citations

Acetylcholine‐induced initiation of thymic lymphoblast DNA synthesis and proliferation

1975 • 30 citations

Acetylcholinesterase in human thymus cells

1985 • 30 citations

[3H]N-methylscopolamine binding to muscarinic receptors in human peripheral blood lymphocytes: Characterization, localization on T-lymphocyte subsets and age-dependent changes

1989 • 29 citations

Determination of acetylcholine, nitrostigmine and acetylcholinesterase activity in four patients with severe nitrostigmine (E 605 forte�) intoxication

1974 • 29 citations

Cholinergic neurons of fetal rat telencephalon in aggregating cell culture respond to NGF as well as to protein kinase C-activating tumor promoters

1986 • 28 citations

Expression of cholinergic muscarinic receptor subtypes mRNA in rat blood mononuclear cells

1994 • 28 citations

IDENTIFICATION OF ACETYLCHOLINE, HISTAMINE, AND 5-HYDROXYTRYPTAMINE IN GIRARDINIA HETEROPHYLLA (DECNE.)

1966 • 27 citations

Acetylcholine and Choline in Human Plasma and Red Blood Cells: A Gas Chromatograph Mass Spectrometric Evaluation

1978 • 27 citations

Intact human lymphocyte membranes respond to muscarinic receptor stimulation by oxotremorine with marked changes in microviscosity and an increase in cyclic GMP

1985 • 26 citations

AN ANALYSIS OF LYMPHOCYTE³H-N-METHYL-SCOPOLAMINE BINDING IN NEUROLOGICAL PATIENTS

1991 • 25 citations

Acetylcholine receptor in rabbit thymus: antigenic similarity between acetylcholine receptors of muscle and thymus.

1980 • 25 citations

Cholinergic muscarinic binding by rat lymphocytes: Effects of antagonist treatment, strain and aging

1986 • 25 citations

Changes in the expression of the cholinergic structures of human T lymphocytes due to maturation and stimulation.

1990 • 25 citations

Liquid chromatography with electrochemical detection for the determination of choline and acetylcholine in plasma and red blood cells

1988 • 24 citations

Depression of T Cell‐Mediated Immunity and Enhancement of Autoantibody Production by Natural Infection with Microorganisms in Spontaneously Hypertensive Rats (SHR)

1988 • 23 citations

Maintenance of constant blood acetylcholine content before and after feeding in young chimpanzees

1997 • 23 citations

Possible Dynamic Neurotransmitter Metabolism Surrounding the Fetus

1999 • 23 citations

The muscarinic agonist pilocarpine inhibits DNA and interferon-γ synthesis in peripheral blood mononuclear cells

1989 • 22 citations

Adrenergic/Cholinergic Immunomodulation in the Rat Model—In VivoVeritas?

1997 • 22 citations

Expression of mRNAs in human thymus coding for the α3 subunit of a neuronal acetylcholine receptor

1991 • 20 citations

The background of the muscarinic system

1995 • 19 citations

Muscarinic cholinergic receptors on murine lympocyte subpopulations

1993 • 18 citations

Cholinergic agonists selectively induce proliferative responses in the mature subpopulation of murine thymocytes

1989 • 18 citations

THE ARREST OF T CELL MATURATION IN SPONTANEOUSLY HYPERTENSIVE RATS WITH A DEFICIENT PRODUCTION OF THYMIC FACTORS

1985 • 17 citations

The alleged occurrence of acetylcholine in ox blood

1933 • 17 citations

Stress-induced changes in muscarinic and β-adrenergic binding sites on rat thymocytes and lymphocytes

1992 • 17 citations

Enhancement of DNA synthesis in rat thymocytes by stimulating their muscarinic acetylcholine receptors.

1992 • 16 citations

Molecular form of human lymphocyte membrane-bound acetylcholinesterase

1987 • 16 citations

Oral administration of KW-5092, a novel gastroprokinetic agent with acetylcholinesterase inhibitory and acetylcholine release enhancing activities, causes a dose-dependent increase in the blood acetylcholine content of beagle dogs

1997 • 16 citations

Muscarinic cholinergic receptors on circulating human lymphocytes: evidence for a particulate binding site.

1983 • 14 citations

Confocal fluorescence microscopy for studying thapsigargin-induced bivalent-cation entry into B cells

1995 • 12 citations

Cholinergic receptors of rat lymphocytes during adjuvant polyarthritis

1982 • 11 citations

Expression of three acetylcholinesterase mRNAs in human lymphocytes.

1999 • 10 citations

Characterization of 3H-N-methylscopolamine binding to intact rat thymocytes.

1990 • 10 citations

Hypothalamic Control of Gastric Secretion

1967 • 10 citations

Age-related changes of natural antitumor resistance in spontaneously hypertensive rats with T-cell depression.

1987 • 9 citations

Determination of acetylcholine content and choline acetyltransferase activity in rabbit blood cells obtained from the buffy coat layer.

1991 • 9 citations

A COMPARISON OF SHAM FEEDING AND TEASING AS STIMULI FOR GASTRIC ACID SECRETION IN THE DOG

1967 • 8 citations

Über das Vorkommen von Acetylcholin im Rinderblut.

1933 • 7 citations

Muscarinic Cholinergic Receptors of Rat Lymphocytes: Effect of Antigen Stimulation and Local Brain Lesion

1994 • 7 citations

Muscarinic Antagonist Binding to Intact Rat Thymocytes.

1990 • 6 citations

M-cholinergic receptors in mice B-lymphocytes in the process of immune response.

1986 • 5 citations

A relationship of central cholinergic functions with enhanced cardiovascular responses to physostigmine in the spontaneously hypertensive rat

1986 • 5 citations

Accumulation of inositol 1,4,5-triphosphate after cholinergic stimulation of human lymphocytes.

1995 • 4 citations

Presence of Acetylcholine in the Blood and its Production by Choline Acetyltransferase in Lymphocytes

1997 • 4 citations

Cholinergic stimulation of RNA synthesis in rat lymphocytes.

1981 • 3 citations

Expression of muscarinic cholinergic receptors on lymphocytes during rheumatoid arthritis.

1986 • 3 citations

Identification and analysis of acetylcholine and choline in guinea pig blood

1990 • 2 citations

Expression of mRNA for muscarinic receptor subtypes and neuronal nicotinic receptor subunits in human mononuclear leukocytes

1999 • 1 citations

Accumulation of inositol phosphates in human lymphocytes after cholinergic stimulation.

1993 • 1 citations