The exocytotic fusion pore and neurotransmitter release

Elastic Properties of Lipid Bilayers: Theory and Possible Experiments

1973 • 5,817 citations

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

Membrane Fusion

1990 • 2,458 citations

Kinetics of swelling of gels

1979 • 1,540 citations

Molecular dissection of the secretory pathway

1992 • 985 citations

Dominant Role of N-Type Ca ²⁺ Channels in Evoked Release of Norepinephrine from Sympathetic Neurons

1988 • 859 citations

Microdomains of High Calcium Concentration in a Presynaptic Terminal

1992 • 837 citations

Delay in vesicle fusion revealed by electrochemical monitoring of single secretory events in adrenal chromaffin cells

1992 • 809 citations

Calcium gradients and buffers in bovine chromaffin cells.

1992 • 746 citations

The molecular machinery for secretion is conserved from yeast to neurons.

1993 • 658 citations

Membrane Fusion

1992 • 613 citations

Calcium ions, active zones and synaptic transmitter release

1988 • 609 citations

Intrinsic curvature hypothesis for biomembrane lipid composition: a role for nonbilayer lipids.

1985 • 599 citations

Release of secretory products during transient vesicle fusion

1993 • 582 citations

The Annexins and Exocytosis

1992 • 549 citations

Capacitance measurements reveal stepwise fusion events in degranulating mast cells

1984 • 506 citations

rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles.

1990 • 486 citations

Lipid-anchored influenza hemagglutinin promotes hemifusion, not complete fusion

1994 • 485 citations

Structural changes after transmitter release at the frog neuromuscular junction.

1981 • 471 citations

INTERACTING PHOSPHOLIPID BILAYERS: Measured Forces and Induced Structural Changes

1981 • 464 citations

Architecture and design of the nuclear pore complex

1992 • 452 citations

A small GTP-binding protein dissociates from synaptic vesicles during exocytosis

1991 • 441 citations

Currents through the fusion pore that forms during exocytosis of a secretory vesicle

1987 • 432 citations

The binding of AP-1 clathrin adaptor particles to Golgi membranes requires ADP-ribosylation factor, a small GTP-binding protein

1993 • 422 citations

Calcium requirements for secretion in bovine chromaffin cells.

1992 • 416 citations

THE NUCLEAR PORE COMPLEX

1995 • 383 citations

Membrane fusion machinery: Insights from synaptic proteins

1993 • 380 citations

Phosphatidylinositol transfer protein required for ATP-dependent priming of Ca2+-activated secretion

1993 • 346 citations

A role for calpactin in calcium-dependent exocytosis in adrenal chromaffin cells

1989 • 321 citations

Living with Clathrin: Its Role in Intracellular Membrane Traffic

1988 • 304 citations

Biomembrane fusion: a new concept derived from model studies using two interacting planar lipid bilayers

1987 • 295 citations

Simultaneous electrical and optical measurements show that membrane fusion precedes secretory granule swelling during exocytosis of beige mouse mast cells.

1987 • 280 citations

The Calcium Signal for Transmitter Secretion from Presynaptic Nerve Terminalsa

1991 • 272 citations

Three types of Ca2+ channel trigger secretion with different efficacies in chromaffin cells

1994 • 263 citations

Properties of the fusion pore that forms during exocytosis of a mast cell secretory vesicle

1990 • 262 citations

A novel 145 kd brain cytosolic protein reconstitutes Ca2+-regulated secretion in permeable neuroendocrine cells

1992 • 261 citations

The synaptic vesicle protein SV2 is a novel type of transmembrane transporter

1992 • 257 citations

GE: A GTP-Binding Protein Mediating Exocytosis

1990 • 256 citations

Molecular Mechanisms and Forces Involved in the Adhesion and Fusion of Amphiphilic Bilayers

1989 • 242 citations

Arrest of membrane fusion events in mast cells by quick-freezing.

1980 • 241 citations

Activation of Exocytosis by the Heterotrimeric G Protein G _i3

1993 • 233 citations

Synaptic vesicle membrane proteins interact to form a multimeric complex.

1992 • 219 citations

Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol

1993 • 218 citations

Beginning of exocytosis captured by rapid-freezing of Limulus amebocytes.

1981 • 212 citations

Molecular Mechanisms of Membrane Fusion

1988 • 209 citations

Inhibition of RabSB expression attenuates Ca2+-dependent exocytosis in rat anterior pituitary cells

1993 • 199 citations

The exocytotic fusion pore.

1992 • 195 citations

Essential synergy between Ca2+ and guanine nucleotides in exocytotic secretion from permeabilized rat mast cells.

1987 • 188 citations

Genetic analysis of membrane differentiation in Paramecium. Freeze-fracture study of the trichocyst cycle in wild-type and mutant strains.

1976 • 185 citations

Exol and Exo2 proteins stimulate calcium-dependent exocytosis in permeabilized adrenal chromaff in cells

1992 • 185 citations

On the theory of membrane fusion. The stalk mechanism.

1984 • 185 citations

Regulated exocytosis

1993 • 179 citations

Role of hydrophobic forces in bilayer adhesion and fusion

1992 • 179 citations

Exocytotic fusion is activated by Rab3a peptides

1992 • 173 citations

The nuclear pore complex

1993 • 166 citations

Stalk mechanism of vesicle fusion

1989 • 159 citations

Tension in secretory granule membranes causes extensive membrane transfer through the exocytotic fusion pore.

1990 • 148 citations

Analysis of diffusional broadening of vesicular packets of catecholamines released from biological cells during exocytosis

1992 • 147 citations

On the structure of the ‘synaptosecretosome’ Evidence for a neurexin/synaptotagmin/syntaxin/Ca²⁺channel complex

1993 • 144 citations

Role of calcium in the adhesion and fusion of bilayers

1993 • 144 citations

Temporal characteristics of quantal secretion of catecholamines from adrenal medullary cells

1993 • 140 citations

Mucin Exocytosis

1991 • 140 citations

Peptides that mimic the pseudosubstrate region of protein kinase C bind to acidic lipids in membranes

1991 • 139 citations

Membrane specializations in the form of regular membr ane-to-m emb r ane attachment sites in Paramecium. a correlated freeze-etching and ultrathin-sectioning analysis

1973 • 138 citations

Membrane flux through the pore formed by a fusogenic viral envelope protein during cell fusion.

1993 • 134 citations

A cytosolic complex of p62 and rab6 associates with TGN38/41 and is involved in budding of exocytic vesicles from the trans-Golgi network

1993 • 133 citations

Guanine nucleotide effects on catecholamine secretion from digitonin-permeabilized adrenal chromaffin cells.

1986 • 131 citations

Simultaneous measurements of cytosolic calcium and secretion in single bovine adrenal chromaffin cells by fluorescent imaging of fura-2 in cocultured cells.

1989 • 127 citations

The Secretory Granule Matrix: A Fast-Acting Smart Polymer

1993 • 125 citations

Quenched flow analysis of exocytosis in Paramecium cells: time course, changes in membrane structure, and calcium requirements revealed after rapid mixing and rapid freezing of intact cells.

1991 • 123 citations

A synthetic peptide of the rab3a effector domain stimulates amylase release from permeabilized pancreatic acini.

1992 • 117 citations

The exocytotic fusion pore modeled as a lipidic pore

1992 • 112 citations

Spatial localization of the stimulus‐induced rise in cytosolic Ca²⁺ in bovine adrenal chromaffin cells

1989 • 112 citations

A Functional Role for GTP-Binding Proteins in Synaptic Vesicle Cycling

1993 • 109 citations

Techniques and concepts in exocytosis: focus on mast cells

1991 • 109 citations

A highly antigenic proteoglycan-like component of cholinergic synaptic vesicles.

1983 • 103 citations

The SV2 Protein of Synaptic Vesicles Is a Keratan Sulfate Proteoglycan

1993 • 102 citations

Acetylcholine, ATP, and Proteoglycan Are Common to Synaptic Vesicles Isolated from the Electric Organs of Electric Eel and Electric Catfish as Well as from Rat Diaphragm

1986 • 102 citations

Binding of basic peptides to acidic lipids in membranes: effects of inserting alanine(s) between the basic residues

1992 • 99 citations

Reversible condensation of mast cell secretory products in vitro

1991 • 98 citations

Organization of cortical cytoskeleton of cultured chromaffin cells and involvement in secretion as revealed by quick-freeze, deep-etching, and double-label immunoelectron microscopy

1992 • 91 citations

A complex of rab3A, SNAP‐25, VAMP/synaptobrevin‐2 and syntaxins in brain presynaptic terminals

1993 • 83 citations

Synthetic peptides of the effector‐binding domain of rab enhance secretion from digitonin‐permeabilized chromaffin cells

1992 • 73 citations

Ionic control of the size of the vesicle matrix of beige mouse mast cells.

1991 • 72 citations

Ra1 and Rab3a are major GTP-binding proteins of axonal rapid transport and synaptic vesicles and do not redistribute following depolarization stimulated synaptosomal exocytosis

1993 • 70 citations

Events leading to the opening and closing of the exocytotic fusion pore have markedly different temperature dependencies. Kinetic analysis of single fusion events in patch-clamped mouse mast cells

1992 • 69 citations

Membrane events in adrenal chromaffin cells during exocytosis: a freeze-etching analysis after rapid cryofixation.

1983 • 59 citations

A Lipid/Protein Complex Hypothesis for Exocytotic Fusion Pore Formationa

1991 • 58 citations

Chromogranins: Universal proteins in secretory organelles from paramecium to man

1990 • 51 citations

Association of three small GTP‐binding proteins with cholinergic synaptic vesicles

1993 • 48 citations

Expression of synaptotagmin and syntaxin associated with N‐type calcium channels in small cell lung cancer

1993 • 44 citations

Properties of single fibre excitatory post‐synaptic potentials in triceps surae motoneurones.

1979 • 43 citations

Synaptic vesicle life cycle and synaptic turnover

1993 • 41 citations

The events leading to secretory granule fusion.

1988 • 29 citations

Synchronous exocytosis in Paramecium cells

1984 • 28 citations

Rab effector domain peptides stimulate the release of neurotransmitter from cell cultured synapses

1993 • 26 citations

A synthetic peptide of the N‐terminus of ADP‐ribosylation factor (ARF) inhibits regulated exocytosis in adrenal chromaffin cells

1993 • 25 citations

[11] Forces between phospholipid bilayers and relationship to membrane fusion

1993 • 23 citations

Patch clamp studies of single intact secretory granules

1993 • 22 citations

Chromaffin granule and PC12 cell chondroitin sulfate proteoglycans and their relation to chromogranin A

1990 • 21 citations

Kinetic characterization of guanine-nucleotide-induced exocytosis from permeabilized rat mast cells

1993 • 18 citations

Distributions of EPSP latency at different group Ia-fiber-alpha-motoneuron connections.

1982 • 9 citations

Is the Activity of the Fusion Pore Scaffold Regulated by a Coincidence Detector?

1994 • 5 citations

Neurotransmitter release through the exocytotic fusion pore

1994 • 4 citations