Establishing cell polarity in development

Integrin Signaling

1999 • 3,705 citations

The development of Drosophila melanogaster

1994 • 3,057 citations

DEVELOPMENT IN DROSOPHILA MELANOGASTER

1927 • 2,909 citations

Multifunctional strands in tight junctions

2001 • 2,392 citations

An Electron Microscopic Study

1987 • 1,144 citations

Origins of Cell Polarity

1996 • 1,024 citations

Integrin-Mediated Activation of Cdc42 Controls Cell Polarity in Migrating Astrocytes through PKCζ

2001 • 1,004 citations

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

2000 • 913 citations

Identification of genes required for cytoplasmic localization in early C. elegans embryos

1988 • 841 citations

MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption

1997 • 836 citations

A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

2000 • 740 citations

New Perspectives on Mechanisms Involved in Generating Epithelial Cell Polarity

1999 • 522 citations

Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo

2001 • 511 citations

An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3

1998 • 508 citations

The Drosophila fusome, a germline-specific organelle, contains membrane skeletal proteins and functions in cyst formation

1994 • 496 citations

Cadherins in embryonic and neural morphogenesis

2000 • 482 citations

Atypical Protein Kinase C Is Involved in the Evolutionarily Conserved Par Protein Complex and Plays a Critical Role in Establishing Epithelia-Specific Junctional Structures

2001 • 426 citations

Junctional Adhesion Molecule Interacts with the PDZ Domain-containing Proteins AF-6 and ZO-1

2000 • 426 citations

The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)

2001 • 387 citations

Junctional adhesion molecule (JAM) binds to PAR-3

2001 • 379 citations

Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans

1998 • 377 citations

Morphogenesis of the Drosophila fusome and its implications for oocyte specification

1998 • 351 citations

Catenins and zonula occludens-1 form a complex during early stages in the assembly of tight junctions.

1996 • 335 citations

Specification of the anteroposterior axis in Caenorhabditis elegans

1996 • 315 citations

Asymmetric cell division during animal development

2001 • 306 citations

PAR‐6 regulates aPKC activity in a novel way and mediates cell‐cell contact‐induced formation of the epithelial junctional complex

2001 • 300 citations

GERMLINE CYST FORMATION IN DROSOPHILA

1997 • 293 citations

The Drosophila Homolog of C. elegans PAR-1 Organizes the Oocyte Cytoskeleton and Directs oskar mRNA Localization to the Posterior Pole

2000 • 291 citations

hu-li tai shao, a gene required for ring canal formation during Drosophila oogenesis, encodes a homolog of adducin.

1992 • 286 citations

A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCζ signaling and cell transformation

2000 • 276 citations

The fusome organizes the microtubule network during oocyte differentiation in Drosophila

2000 • 266 citations

A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans

1996 • 262 citations

ROLE OF TIGHT JUNCTIONS IN ESTABLISHING AND MAINTAINING CELL POLARITY

1998 • 255 citations

THE TIGHT JUNCTION: Morphology to Molecules

1998 • 255 citations

A central role for microtubules in the differentiation of Drosophila oocytes

1993 • 252 citations

PARsing Embryonic Polarity

2000 • 248 citations

The microtubule motor cytoplasmic dynein is required for spindle orientation during germline cell divisions and oocyte differentiation in Drosophila

1997 • 246 citations

Control of spindle orientation in Drosophila by the Par-3-related PDZ-domain protein Bazooka

1998 • 233 citations

CDC-42 controls early cell polarity and spindle orientation in C. elegans

2001 • 222 citations

Reciprocal localization of Nod and kinesin fusion proteins indicates microtubule polarity in the Drosophila oocyte, epithelium, neuron and muscle

1997 • 221 citations

Drosophila Lissencephaly-1 functions with Bic-D and dynein in oocyte determination and nuclear positioning

1999 • 220 citations

E-cadherin-mediated Cell-Cell Attachment Activates Cdc42

2000 • 214 citations

The Nonmuscle Myosin Regulatory Light Chain Gene mlc-4 Is Required for Cytokinesis, Anterior-Posterior Polarity, and Body Morphology during Caenorhabditis elegans Embryogenesis

1999 • 203 citations

INTERCELLULAR MIGRATION OF CENTRIOLES IN THE GERMARIUM OF DROSOPHILA MELANOGASTER

1970 • 201 citations

α-spectrin is required for germline cell division and differentiation in the Drosophila ovary

1996 • 195 citations

Polarization of the anterior–posterior axis of C. elegans is a microtubule-directed process

2000 • 177 citations

Tight Junction, a Platform for Trafficking and Signaling Protein Complexes

2000 • 175 citations

A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formation

2000 • 173 citations

EARLY PATTERNING OF THE C. ELEGANS EMBRYO

1998 • 173 citations

Mammalian homologues of C. elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity

1997 • 168 citations

Microtubules Are a General Component of mRNA Localization Systems in Drosophila Oocytes

1995 • 166 citations

Asymmetric cell division: fly neuroblast meets worm zygote

2001 • 160 citations

CDC-42 regulates PAR protein localization and function to control cellular and embryonic polarity in C. elegans

2001 • 154 citations

The spd-2 gene is required for polarization of the anteroposterior axis and formation of the sperm asters in the Caenorhabditis elegans zygote

2000 • 153 citations

Homophilic Interaction of Junctional Adhesion Molecule

2000 • 153 citations

The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1

2000 • 145 citations

The coronin-like protein POD-1 is required for anterior-posterior axis formation and cellular architecture in the nematode Caenorhabditis elegans

1999 • 140 citations

Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C

2001 • 138 citations

Drosophila par-1 is required for oocyte differentiation and microtubule organization

2001 • 137 citations

Multiple effects of colchicine on oogenesis in Drosophila: Induced sterility and switch of potential oocyte to nurse-cell developmental pathway

1983 • 136 citations

Lis1, the Drosophila homolog of a human lissencephaly disease gene, is required for germline cell division and oocyte differentiation

1999 • 131 citations

PAR-1 is required for the maintenance of oocyte fate in Drosophila

2001 • 106 citations

Centrosome migration into the Drosophila oocyte is independent of BicD and egl, and of the organisation of the microtubule cytoskeleton

2001 • 101 citations

Anucleate Caenorhabditis elegans sperm can crawl, fertilize oocytes and direct anterior-posterior polarization of the 1-cell embryo

2000 • 101 citations

Assembly of tight junctions during early vertebrate development

2000 • 99 citations

Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction

2000 • 93 citations

Bazooka and PAR-6 are required with PAR-1 for the maintenance of oocyte fate in Drosophila

2001 • 87 citations

Mutations in ooc-5 and ooc-3 Disrupt Oocyte Formation and the Reestablishment of Asymmetric PAR Protein Localization in Two-Cell Caenorhabditis elegans Embryos

1999 • 67 citations

Asymmetric division of Drosophila neural stem cells: a basis for neural diversity

2000 • 63 citations

Cell polarity in the early Caenorhabditis elegans embryo

1999 • 56 citations

pod-2, along with pod-1, Defines a New Class of Genes Required for Polarity in the Early Caenorhabditis elegans Embryo

2001 • 49 citations

OOC-3, a novel putative transmembrane protein required for establishment of cortical domains and spindle orientation in the P1 blastomere of C. elegans embryos

2000 • 35 citations

When cells tell their neighbors which direction to divide

2000 • 30 citations

Cytoplasmic flow and the establishment of polarity in C. elegans 1-cell embryos

2000 • 28 citations