OOC-3, a novel putative transmembrane protein required for establishment of cortical domains and spindle orientation in the P1 blastomere of C. elegans embryos

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

1991 • 3,108 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

A C-terminal signal prevents secretion of luminal ER proteins

1987 • 2,189 citations

par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed

1995 • 1,099 citations

Origins of Cell Polarity

1996 • 1,024 citations

Generation of asymmetry and segregation of germ-line granules in early C. elegans embryos

1983 • 534 citations

Mechanisms of asymmetric cell division: Two Bs or not two Bs, that is the question

1992 • 527 citations

Short cytoplasmic sequences serve as retention signals for transmembrane proteins in the endoplasmic reticulum

1989 • 499 citations

cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila

1995 • 480 citations

Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos

1995 • 407 citations

Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans

1998 • 377 citations

Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans.

1987 • 346 citations

An N-terminal double-arginine motif maintains type II membrane proteins in the endoplasmic reticulum.

1994 • 315 citations

Specification of the anteroposterior axis in Caenorhabditis elegans

1996 • 315 citations

Formation of the first cleavage spindle in nematode embryos

1984 • 307 citations

par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3

1996 • 271 citations

CELL POLARITY AND MORPHOGENESIS IN BUDDING YEAST

1998 • 269 citations

PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos

1996 • 254 citations

Centrosome movement in the early divisions of Caenorhabditis elegans: a cortical site determining centrosome position.

1989 • 250 citations

Control of spindle orientation in Drosophila by the Par-3-related PDZ-domain protein Bazooka

1998 • 233 citations

Organization of the sea urchin egg endoplasmic reticulum and its reorganization at fertilization.

1991 • 225 citations

The dynactin complex is required for cleavage plane specification in early Caenorhabditis elegans embryos

1998 • 195 citations

ZYG-9, A Caenorhabditis elegans Protein Required for Microtubule Organization and Function, Is a Component of Meiotic and Mitotic Spindle Poles

1998 • 173 citations

EARLY PATTERNING OF THE C. ELEGANS EMBRYO

1998 • 173 citations

Dissection of Cell Division Processes in the One Cell Stage Caenorhabditis elegans Embryo by Mutational Analysis

1999 • 170 citations

Mammalian homologues of C. elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity

1997 • 168 citations

Transport of Axl2p Depends on Erv14p, an ER–Vesicle Protein Related to the Drosophila cornichon Gene Product

1998 • 139 citations

CAENORHABDITIS ELEGANS DEFICIENCY MAPPING

1984 • 134 citations

Control of cleavage spindle orientation in Caenorhabditis elegans: the role of the genes par-2 and par-3.

1995 • 134 citations

CROSSOVER SUPPRESSORS AND BALANCED RECESSIVE LETHALS IN CAENORHABDITIS ELEGANS

1978 • 133 citations

An analysis of the role of microfilaments in the establishment and maintenance of asymmetry in Caenorhabditis elegans zygotes

1988 • 131 citations

A Genetic Screen for Temperature-Sensitive Cell-Division Mutants of Caenorhabditis elegans

1998 • 125 citations

Transient localized accumulation of actin in Caenorhabditis elegans blastomeres with oriented asymmetric divisions

1994 • 120 citations

Establishment of gut fate in the E lineage of C. elegans: the roles of lineage-dependent mechanisms and cell interactions

1993 • 106 citations

Brief cytochalasin-induced disruption of microfilaments during a critical interval in 1-cell C. elegans embryos alters the partitioning of developmental instructions to the 2-cell embryo

1990 • 100 citations

A calsequestrin-like protein in the endoplasmic reticulum of the sea urchin: localization and dynamics in the egg and first cell cycle embryo.

1989 • 100 citations

Maternal-effect lethal mutations on linkage group II of Caenorhabditis elegans.

1988 • 100 citations

Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans

1998 • 94 citations

Budding and cell polarity in Saccharomyces cerevisiae

1991 • 89 citations

par-2, a gene required for blastomere asymmetry in Caenorhabditis elegans, encodes zinc-finger and ATP-binding motifs.

1994 • 87 citations

Cleavage Plane Specification in C. elegans: How to Divide the Spoils

1996 • 76 citations

Cortical domains and the mechanisms of asymmetric cell division

1996 • 49 citations

Distribution of a Ca2+ storing site in PtK2 cells during interphase and mitosis. An immunocytochemical study using an antibody against calreticulin.

1995 • 20 citations