SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity

Identification and Importance of Brown Adipose Tissue in Adult Humans

2009 • 4,006 citations

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

2000 • 3,355 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Obesity and the Regulation of Energy Balance

2001 • 2,387 citations

PRDM16 controls a brown fat/skeletal muscle switch

2008 • 2,190 citations

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

2004 • 1,896 citations

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1997 • 1,891 citations

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

1997 • 1,835 citations

Sirtuins in mammals: insights into their biological function

2007 • 1,625 citations

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

2004 • 1,610 citations

Towards a molecular understanding of adaptive thermogenesis

2000 • 1,560 citations

Anatomy and regulation of the central melanocortin system

2005 • 1,511 citations

Hypothalamic mTOR Signaling Regulates Food Intake

2006 • 1,217 citations

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α

2007 • 1,185 citations

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

2003 • 1,075 citations

Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure

2005 • 1,053 citations

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

2007 • 1,036 citations

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

2009 • 1,026 citations

Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area

1999 • 909 citations

Leptin Receptor Signaling in POMC Neurons Is Required for Normal Body Weight Homeostasis

2004 • 895 citations

Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon cre-mediated excision

2000 • 841 citations

Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord

1998 • 797 citations

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

2000 • 795 citations

Leptin Directly Activates SF1 Neurons in the VMH, and This Action by Leptin Is Required for Normal Body-Weight Homeostasis

2006 • 747 citations

SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B

2007 • 725 citations

A Unique Metalolic Sysdrone Causes Obesity in the Melanocortin-3 Receptor-Deficient Mouse

2000 • 677 citations

Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity

2007 • 669 citations

Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex

2009 • 662 citations

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

2008 • 641 citations

SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice

2008 • 622 citations

Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction

2006 • 605 citations

Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice

2005 • 602 citations

SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR

2007 • 597 citations

Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity.

1995 • 539 citations

Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1

2007 • 526 citations

Differential Effects of Interleukin-6 and -10 on Skeletal Muscle and Liver Insulin Action In Vivo

2004 • 526 citations

The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation.

1996 • 513 citations

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

2007 • 482 citations

Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake

2006 • 436 citations

The central melanocortin system directly controls peripheral lipid metabolism

2007 • 380 citations

EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses

2007 • 340 citations

Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat

2001 • 332 citations

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

2008 • 328 citations

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity

2006 • 307 citations

Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability

2008 • 300 citations

Transcriptional control of brown adipocyte development and physiological function—of mice and men

2009 • 294 citations

Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats.

1999 • 293 citations

Proopiomelanocortin and Energy Balance: Insights from Human and Murine Genetics

2004 • 228 citations

Minireview: Human Obesity—Lessons from Monogenic Disorders

2003 • 224 citations

Heterozygosity for a POMC-Null Mutation and Increased Obesity Risk in Humans

2006 • 223 citations

Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System

2009 • 193 citations

Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin

2004 • 180 citations

SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats

2009 • 177 citations

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

2009 • 165 citations

PDK1 Deficiency in POMC-Expressing Cells Reveals FOXO1-Dependent and -Independent Pathways in Control of Energy Homeostasis and Stress Response

2008 • 160 citations

Evidence that β-endorphin is synthesized in cells in the nucleus tractus solitarius: detection of POMC mRNA

1992 • 150 citations

Sirtuins: novel targets for metabolic disease.

2008 • 142 citations

An Integrative View of Obesity

2007 • 140 citations

Enhanced Leptin-Stimulated Pi3k Activation in the CNS Promotes White Adipose Tissue Transdifferentiation

2007 • 132 citations

Leptin and the Cardiovascular System

2004 • 113 citations

Distinct Effects of Leptin and a Melanocortin Receptor Agonist Injected Into Medial Hypothalamic Nuclei on Glucose Uptake in Peripheral Tissues

2009 • 105 citations

Brain-adipose tissue neural crosstalk

2007 • 95 citations

Monitoring FoxO1 Localization in Chemically Identified Neurons

2008 • 68 citations

Differential effects of fasting and leptin on proopiomelanocortin peptides in the arcuate nucleus and in the nucleus of the solitary tract

2007 • 64 citations

Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet

2007 • 46 citations