Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

1999 • 2,199 citations

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

1990 • 1,835 citations

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

1996 • 1,769 citations

Extrachromosomal rDNA Circles— A Cause of Aging in Yeast

1997 • 1,477 citations

Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription

1990 • 1,343 citations

The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity and Lifetime Energy Intake

1986 • 968 citations

The genetics of caloric restriction in Caenorhabditis elegans

1998 • 918 citations

Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.

1993 • 795 citations

Characterization of Five Human cDNAs with Homology to the Yeast SIR2 Gene: Sir2-like Proteins (Sirtuins) Metabolize NAD and May Have Protein ADP-Ribosyltransferase Activity

1999 • 781 citations

Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast

1995 • 778 citations

Four Genes Responsible for a Position Effect on Expression From HML and HMR in Saccharomyces cerevisiae

1987 • 709 citations

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.

1995 • 601 citations

An unusual form of transcriptional silencing in yeast ribosomal DNA.

1997 • 590 citations

A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA

1989 • 550 citations

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance

1996 • 478 citations

Relocalization of Telomeric Ku and SIR Proteins in Response to DNA Strand Breaks in Yeast

1999 • 458 citations

An Enzymatic Activity in the Yeast Sir2 Protein that Is Essential for Gene Silencing

1999 • 388 citations

Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast.

1997 • 376 citations

Efficient Transcriptional Silencing in Saccharomyces cerevisiae Requires a Heterochromatin Histone Acetylation Pattern

1996 • 363 citations

MEC1-Dependent Redistribution of the Sir3 Silencing Protein from Telomeres to DNA Double-Strand Breaks

1999 • 332 citations

Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae

1997 • 330 citations

Histone H3 amino terminus is required for telomeric and silent mating locus repression in yeast

1994 • 227 citations

Calorie Restriction in Primates: Will It Work and How Will We Know?

1999 • 187 citations

Calendar life span versus budding lifespan of Saccharomyces cerevisiae

1980 • 173 citations

CobB, a New Member of the SIR2 Family of Eucaryotic Regulatory Proteins, Is Required to Compensate for the Lack of Nicotinate Mononucleotide:5,6-Dimethylbenzimidazole Phosphoribosyltransferase Activity in cobT Mutants during Cobalamin Biosynthesis in Salmonella typhimurium LT2

1998 • 146 citations

ADP-ribosylation of nuclear proteins in vivo. Identification of histone H2B as a major acceptor for mono- and poly(ADP-ribose) in dimethyl sulfate-treated hepatoma AH 7974 cells.

1984 • 141 citations

DNA repair-associated ADP-ribosylation in vivo. Modification of histone H1 differs from that of the principal acceptor proteins.

1984 • 138 citations

Life and Cancer Without Telomerase

1997 • 85 citations

Production of anti‐(ADP‐ribose) antibodies with the aid of a dinucleotide‐pyrophosphatase‐resistant hapten and their application for the detection of mono(ADP‐ribosyl)ated polypeptides

1986 • 57 citations

Inhibitors and activators of ADP-ribosylation reactions

1994 • 56 citations

γ-Radiation induced ADP-ribosyl transferase activity and mammalian longevity

1985 • 38 citations