Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

Obesity is associated with macrophage accumulation in adipose tissue

2003 • 8,349 citations

Obesity is associated with macrophage accumulation in adipose tissue

2003 • 7,795 citations

The metabolic syndrome

2010 • 6,321 citations

Definition of Metabolic Syndrome

2004 • 5,872 citations

Global and societal implications of the diabetes epidemic

2001 • 5,825 citations

The metabolic syndrome

2005 • 5,005 citations

Prevalence of Overweight and Obesity Among US Children, Adolescents, and Adults, 1999-2002

2004 • 4,576 citations

Resveratrol improves health and survival of mice on a high-calorie diet

2006 • 4,102 citations

Inflammation, stress, and diabetes

2005 • 3,786 citations

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

2006 • 3,767 citations

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

2004 • 3,671 citations

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

2000 • 3,355 citations

A central role for JNK in obesity and insulin resistance

2002 • 3,225 citations

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1999 • 3,119 citations

Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

2004 • 3,100 citations

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

2005 • 2,981 citations

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

2000 • 2,831 citations

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

2001 • 2,550 citations

Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase

2004 • 2,531 citations

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

2006 • 2,496 citations

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

2001 • 2,042 citations

Nuclear Receptors and Lipid Physiology: Opening the X-Files

2001 • 2,040 citations

Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase

2004 • 1,877 citations

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

2001 • 1,849 citations

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

2001 • 1,782 citations

Molecular mediators of hepatic steatosis and liver injury

2004 • 1,763 citations

Molecular mediators of hepatic steatosis and liver injury

2004 • 1,709 citations

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

2007 • 1,630 citations

Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting

1999 • 1,589 citations

Increasing Prevalence of the Metabolic Syndrome Among U.S. Adults

2004 • 1,525 citations

The Sir2 Family of Protein Deacetylases

2004 • 1,478 citations

Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

2007 • 1,400 citations

Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

2007 • 1,386 citations

Phylogenetic Classification of Prokaryotic and Eukaryotic Sir2-like Proteins

2000 • 1,360 citations

Mammalian SIRT1 Represses Forkhead Transcription Factors

2004 • 1,352 citations

CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

2001 • 1,351 citations

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

2008 • 1,328 citations

Mechanism of Hepatic Insulin Resistance in Non-alcoholic Fatty Liver Disease

2004 • 1,276 citations

Inflammation, stress, and diabetes

2005 • 1,203 citations

The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes

2000 • 1,125 citations

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

2003 • 1,075 citations

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

2000 • 946 citations

Sirt1 protects against high-fat diet-induced metabolic damage

2008 • 895 citations

Nuclear Receptor Expression Links the Circadian Clock to Metabolism

2006 • 895 citations

Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control

1998 • 763 citations

Definition of Metabolic Syndrome

2004 • 712 citations

A phylogenetically conserved NAD ⁺ -dependent protein deacetylase activity in the Sir2 protein family

2000 • 703 citations

SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice

2008 • 622 citations

SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR

2007 • 597 citations

The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis

2002 • 594 citations

LXRS AND FXR: The Yin and Yang of Cholesterol and Fat Metabolism

2005 • 571 citations

Tissue-specific regulation of SIRT1 by calorie restriction

2008 • 546 citations

FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction

2005 • 541 citations

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

2008 • 529 citations

Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1

2007 • 526 citations

Sirtuins as potential targets for metabolic syndrome

2006 • 445 citations

Defect in Peroxisome Proliferator-activated Receptor α-inducible Fatty Acid Oxidation Determines the Severity of Hepatic Steatosis in Response to Fasting

2000 • 422 citations

Genetic links between diet and lifespan: shared mechanisms from yeast to humans

2007 • 415 citations

Retinoid X Receptor Heterodimers in the Metabolic Syndrome

2005 • 371 citations

SIRT1 Regulates HIV Transcription via Tat Deacetylation

2005 • 322 citations

Comprehensive Analysis of PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E1"><mml:mi>α</mml:mi></mml:math>-Dependent Regulation of Hepatic Lipid Metabolism by Expression Profiling

2007 • 210 citations

Mechanisms of Disease: pathogenesis of nonalcoholic fatty liver disease

2005 • 207 citations

Peroxisome Proliferator-Activated Receptor α Protects against Obesity-Induced Hepatic Inflammation

2007 • 183 citations

The role of the liver in metabolic homeostasis: Implications for inborn errors of metabolism

1991 • 156 citations

Genome-wide Coactivation Analysis of PGC-1α Identifies BAF60a as a Regulator of Hepatic Lipid Metabolism

2008 • 152 citations

Chromatin remodeling, metabolism and circadian clocks: The interplay of CLOCK and SIRT1

2008 • 113 citations

Peroxisome Proliferator-induced Long Chain Acyl-CoA Thioesterases Comprise a Highly Conserved Novel Multi-gene Family Involved in Lipid Metabolism

1999 • 104 citations

Peroxisome Proliferator-activated Receptor α Inhibits Hepatic S14 Gene Transcription

1996 • 84 citations

A Simple Enzymatic Quantitative Analysis of Triglycerides in Tissues.

1992 • 70 citations