From Transcript to Protein

Identification and characterization of a spinal muscular atrophy-determining gene

1995 • 3,722 citations

Conserved Structures and Diversity of Functions of RNA-Binding Proteins

1994 • 1,873 citations

Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry

1996 • 1,687 citations

hnRNP PROTEINS AND THE BIOGENESIS OF mRNA

1993 • 1,486 citations

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

1995 • 1,127 citations

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1990 • 949 citations

Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm

1992 • 825 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

A novel nuclear structure containing the survival of motor neurons protein.

1996 • 759 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

The superfamily of arginine/serine-rich splicing factors.

1995 • 671 citations

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.

1996 • 671 citations

Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.

1995 • 606 citations

Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

1993 • 544 citations

A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway

1995 • 529 citations

Regulation by HIV Rev depends upon recognition of splice sites

1989 • 517 citations

Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript.

1994 • 511 citations

A nuclear cap binding protein complex involved in pre-mRNA splicing

1994 • 506 citations

CPEB is a specificity factor that mediates cytoplasmic polyadenylation during Xenopus oocyte maturation

1994 • 451 citations

Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm

1989 • 417 citations

Premature translational termination triggers mRNA decapping

1994 • 399 citations

Sequence-specific RNA binding by the HIV-1 Rev protein

1989 • 384 citations

THE NUCLEAR PORE COMPLEX

1995 • 383 citations

Specific binding of HIV-1 recombinant Rev protein to the Rev-responsive element in vitro

1989 • 377 citations

Isolation and characterization of RAT1: an essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.

1992 • 370 citations

A cap-binding protein complex mediating U snRNA export

1995 • 347 citations

A Novel Spliceosome Containing U11, U12, and U5 snRNPs Excises a Minor Class (AT–AC) Intron In Vitro

1996 • 329 citations

Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins

1995 • 308 citations

Mechanism of action of regulatory proteins encoded by complex retroviruses

1992 • 299 citations

CPEB controls the cytoplasmic polyadenylation of cyclin, Cdk2 and c-mos mRNAs and is necessary for oocyte maturation in Xenopus.

1996 • 287 citations

Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology.

1990 • 281 citations

Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport.

1994 • 278 citations

Iron regulatory protein prevents binding of the 43S translation pre-initiation complex to ferritin and eALAS mRNAs.

1994 • 273 citations

A human nucleoporin-like protein that specifically interacts with HIV Rev

1995 • 268 citations

Translational control by cytoplasmic polyadenylation of c-mos mRNA is necessary for oocyte maturation in the mouse.

1994 • 243 citations

Conserved Sequences in a Class of Rare Eukaryotic Nuclear Introns with Non-consensus Splice Sites

1994 • 233 citations

Requirement of U12 snRNA for in Vivo Splicing of a Minor Class of Eukaryotic Nuclear Pre-mRNA Introns

1996 • 230 citations

Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast

1995 • 223 citations

A Pre-mRNA-Binding Protein Accompanies the RNA from the Gene through the Nuclear Pores and into Polysomes

1996 • 220 citations

RNA-RNA interactions in the spliceosome: Unraveling the ties that bind

1994 • 208 citations

Iron regulatory elements (IREs): a family of mRNA non-coding sequences

1994 • 207 citations

Protein-mediated nuclear export of RNA: 5S rRNA containing small RNPs in xenopus oocytes

1990 • 205 citations

Nitric Oxide and Oxidative Stress (H₂O₂) Control Mammalian Iron Metabolism by Different Pathways

1996 • 194 citations

RNA—protein complexes

1996 • 192 citations

A conditional allele of the novel repeat-containing yeast nucleoporin RAT7/NUP159 causes both rapid cessation of mRNA export and reversible clustering of nuclear pore complexes.

1995 • 192 citations

Mutational analysis of mammalian poly(A) polymerase identifies a region for primer binding and catalytic domain, homologous to the family X polymerases, and to other nucleotidyltransferases.

1996 • 189 citations

The biochemistry of polyadenylation

1996 • 186 citations

The influenza virus NS1 protein: a novel inhibitor of pre-mRNA splicing.

1994 • 185 citations

Transcription-Dependent and Transcription-Independent Nuclear Transport of hnRNP Proteins

1991 • 184 citations

Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements.

1996 • 182 citations

RNA Export

1995 • 181 citations

A yeast RNA-binding protein shuttles between the nucleus and the cytoplasm.

1994 • 164 citations

No end yet to messenger RNA 3′ processing!

1995 • 153 citations

The influenza virus NS1 protein binds to a specific region in human U6 snRNA and inhibits U6-U2 and U6-U4 snRNA interactions during splicing.

1995 • 150 citations

hnRNP proteins:Localization and transport between the nucleus and the cytoplasm

1993 • 150 citations

NUP145 encodes a novel yeast glycine-leucine-phenylalanine-glycine (GLFG) nucleoporin required for nuclear envelope structure.

1994 • 140 citations

Proteins Binding to 5′ Untranslated Region Sites: a General Mechanism for Translational Regulation of mRNAs in Human and Yeast Cells

1994 • 136 citations

Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae.

1994 • 133 citations

Nonsense Mutations Inhibit RNA Splicing in a Cell-Free System: Recognition of Mutant Codon Is Independent of Protein Synthesis

1996 • 132 citations

Succinate Dehydrogenase b mRNA of Drosophila melanogaster Has a Functional Iron-responsive Element in Its 5′-Untranslated Region

1995 • 127 citations

mRNA 5' cap-binding protein eIF4E and control of cell growth

1996 • 123 citations

A single nucleotide substitution in the internal ribosome entry site of foot-and-mouth disease virus leads to enhanced cap-independent translation in vivo

1993 • 122 citations

Nuclear transport of human immunodeficiency virus type 1, visna virus, and equine infectious anemia virus Rev proteins: identification of a family of transferable nuclear export signals

1996 • 119 citations

Influenza virus NS1 protein stimulates translation of the M1 protein

1994 • 117 citations

RNA‐protein interactions

1995 • 113 citations

A conditional yeast mutant deficient in mRNA transport from nucleus to cytoplasm.

1992 • 112 citations

The search for the primary function of the Ran GTPase continues

1996 • 111 citations

NOP3 is an essential yeast protein which is required for pre-rRNA processing.

1992 • 111 citations

Cap-specific mRNA (nucleoside-O2'-)-methyltransferase and poly(A) polymerase stimulatory activities of vaccinia virus are mediated by a single protein.

1992 • 108 citations

Cytoplasmic 3′ poly(A) addition induces 5′ cap ribose methylation: implications for translational control of maternal mRNA.

1995 • 107 citations

The HIV-1 Rev protein: prototype of a novel class of eukaryotic post-transcriptional regulators

1991 • 106 citations

A novel nuclear pore protein Nup82p which specifically binds to a fraction of Nsp1p.

1995 • 102 citations

mRNA transport in yeast: time to reinvestigate the functions of the nucleolus.

1995 • 101 citations

Low cytoplasmic mRNA levels of immunoglobulin kappa light chain genes containing nonsense codons correlate with inefficient splicing.

1994 • 97 citations

Molecular analysis of the coiled body

1995 • 89 citations

Nucleolar accumulation of poly (A)+ RNA in heat-shocked yeast cells: implication of nucleolar involvement in mRNA transport.

1995 • 88 citations

nup1 mutants exhibit pleiotropic defects in nuclear pore complex function.

1994 • 86 citations

Signal Sequences That Target Nuclear Import and Nuclear Export of Pre-mRNA-binding Proteins

1995 • 83 citations

A functional interaction between Rev and yeast pre-mRNA is related to splicing complex formation.

1994 • 78 citations

A nuclear cap binding protein from HeLa cells

1990 • 78 citations

Analysis of RNA-binding proteins by in vitro genetic selection: identification of an amino acid residue important for locking U1A onto its RNA target.

1995 • 59 citations

Taking from the cytoplasm and giving to the pore: soluble transport factors in nuclear protein import

1995 • 46 citations

The Balbiani ring particle: a model for the assembly and export of RNPs from the nucleus?

1993 • 39 citations

Cloning of a complementary DNA encoding an 80 kilodalton nuclear cap binding protein

1994 • 38 citations

RNA:RNA interactions in the spliceosome

1993 • 12 citations