A functional interaction between Rev and yeast pre-mRNA is related to splicing complex formation.

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA

1989 • 1,280 citations

Nucleotide sequence of the AIDS virus, LAV

1985 • 1,225 citations

A Method for Gene Disruption That Allows Repeated Use of URA3 Selection in the Construction of Multiply Disrupted Yeast Strains

1987 • 887 citations

Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev function

1989 • 742 citations

HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA

1986 • 673 citations

A second post-transcriptional trans-activator gene required for HTLV-III replication

1986 • 639 citations

rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA.

1989 • 634 citations

Regulation by HIV Rev depends upon recognition of splice sites

1989 • 517 citations

Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs

1986 • 490 citations

HIV-1 structural gene expression requires binding of the rev trans-activator to its RNA target sequence

1990 • 457 citations

Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm

1989 • 417 citations

Spliceosome assembly in yeast.

1987 • 402 citations

The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization

1989 • 400 citations

Sequence-specific RNA binding by the HIV-1 Rev protein

1989 • 384 citations

Specific binding of HIV-1 recombinant Rev protein to the Rev-responsive element in vitro

1989 • 377 citations

A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5′ cleavage site.

1988 • 364 citations

The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region

1989 • 359 citations

HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element region

1990 • 354 citations

Tandem gene amplification mediates copper resistance in yeast.

1982 • 354 citations

Mammalian Glucocorticoid Receptor Derivatives Enhance Transcription in Yeast

1988 • 315 citations

Primary structure and transcription of an amplified genetic locus: the CUP1 locus of yeast.

1984 • 279 citations

Mutational definition of the human immunodeficiency virus type 1 Rev activation domain

1991 • 276 citations

Oligomerization and RNA binding domains of the type 1 human immunodeficiency virus Rev protein: a dual function for an arginine-rich binding motif.

1991 • 253 citations

Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA.

1994 • 248 citations

Structural analysis of the interaction between the human immunodeficiency virus Rev protein and the Rev response element.

1991 • 226 citations

Function and Autoregulation of Yeast Copperthionein

1985 • 216 citations

mRNA splicing efficiency in yeast and the contribution of nonconserved sequences

1985 • 194 citations

Rev and the fate of pre-mRNA in the nucleus: implications for the regulation of RNA processing in eukaryotes.

1993 • 188 citations

Secondary Structure is the Major Determinant for Interaction of HIV rev Protein with RNA

1990 • 188 citations

Expression of a beta-galactosidase gene containing the ribosomal protein 51 intron is sensitive to the rna2 mutation of yeast.

1983 • 180 citations

Mutational analysis of pre-mRNA splicing in Saccharomyces cerevisiae using a sensitive new reporter gene, CUP1.

1993 • 178 citations

Expression of heterologous genes in Saccharomyces cerevisiae from vectors utilizing the glyceraldehyde-3-phosphate dehydrogenase gene promoter

1984 • 174 citations

Mutational analysis of the human immunodeficiency virus type 1 Rev transactivator: essential residues near the amino terminus

1990 • 158 citations

U1 small nuclear RNA plays a direct role in the formation of a rev-regulated human immunodeficiency virus env mRNA that remains unspliced.

1990 • 151 citations

Specific regulation of mRNA splicing in vitro by a peptide from HIV-1 Rev

1991 • 143 citations

A point mutation in the conserved hexanucleotide at a yeast 5′ splice junction uncouples recognition, cleavage, and ligation

1985 • 129 citations

Identification oftrans-dominant HIV-1 rev protein mutants by direct transfer of bacterially produced proteins into human cells

1990 • 128 citations

A human cell factor is essential for HIV-1 Rev action.

1990 • 120 citations

Minimal Rev-response element for type 1 human immunodeficiency virus

1991 • 117 citations

A quantitative analysis of the effects of 5′ junction and TACTAAC box mutants and mutant combinations on yeast mRNA splicing

1985 • 115 citations

The HIV-1 Rev protein: prototype of a novel class of eukaryotic post-transcriptional regulators

1991 • 106 citations

The basic domain of Rev from human immunodeficiency virus type 1 specifically blocks the entry of U4/U6.U5 small nuclear ribonucleoprotein in spliceosome assembly

1993 • 102 citations

trans-dominant inhibition of human immunodeficiency virus type 1 Rev occurs through formation of inactive protein complexes

1992 • 93 citations

RNA splicing and intron turnover are greatly diminished by a mutant yeast branch point.

1986 • 80 citations

Exon mutations uncouple 5′ splice site selection from U1 snRNA pairing

1990 • 78 citations

Rev and the Fate of Pre-mRNA in the Nucleus: Implications for the Regulation of RNA Processing in Eukaryotes

1993 • 78 citations

Messenger RNA Transport and HIV rev Regulation

1990 • 67 citations

Human immunodeficiency virus env expression becomes Rev-independent if the env region is not defined as an intron

1994 • 66 citations

A novel role for the 3' region of introns in pre-mRNA splicing of Saccharomyces cerevisiae.

1987 • 62 citations

Universally conserved and yeast-specific U1 snRNA sequences are important but not essential for U1 snRNP function.

1990 • 41 citations