Hypermethylation of tumor suppressor genes in cancer

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene

1993 • 2,906 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1998 • 1,852 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

Mutations of the VHL tumour suppressor gene in renal carcinoma

1994 • 1,719 citations

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 • 1,542 citations

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.

1997 • 1,465 citations

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

1995 • 1,353 citations

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

1999 • 1,252 citations

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1994 • 1,205 citations

Aberrant methylation of p16 ^INK4a is an early event in lung cancer and a potential biomarker for early diagnosis

1998 • 953 citations

Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients.

1999 • 920 citations

Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability.

1998 • 855 citations

Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis.

1994 • 840 citations

E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas.

1995 • 803 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.

1995 • 635 citations

Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas.

1997 • 632 citations

Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers

1998 • 629 citations

Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

1996 • 585 citations

Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma

1989 • 540 citations

MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas

1998 • 498 citations

Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells.

1994 • 481 citations

Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene.

1991 • 467 citations

Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes.

1996 • 465 citations

Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia–lymphoma cells

1998 • 436 citations

Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies.

1997 • 420 citations

Methylation of the BRCA1 gene in sporadic breast cancer.

1997 • 384 citations

hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability.

1999 • 374 citations

Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability.

1999 • 369 citations

Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers.

1999 • 366 citations

Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia.

1998 • 366 citations

The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53

1998 • 357 citations

Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics

1999 • 353 citations

Methylation of the p15INK4b Gene in Myelodysplastic Syndromes Is Frequent and Acquired During Disease Progression

1998 • 352 citations

Mapping Patterns of CpG Island Methylation in Normal and Neoplastic Cells Implicates Both Upstream and Downstream Regions inde Novo Methylation

1997 • 323 citations

Hypermethylation of the DAP-Kinase CpG Island Is a Common Alteration in B-Cell Malignancies

1999 • 319 citations

CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene.

1993 • 317 citations

MLH1 Promoter Methylation and Gene Silencing is the Primary Cause of Microsatellite Instability in Sporadic Endometrial Cancers

1999 • 316 citations

Absence of p16(INK4) protein is restricted to the subset of lung cancer lines that retains wildtype RB

1995 • 314 citations

p16INK4a Gene Inactivation by Deletions, Mutations, and Hypermethylation Is Associated With Transformed and Aggressive Variants of Non-Hodgkin's Lymphomas

1998 • 300 citations

Association between CpG island methylation and microsatellite instability in colorectal cancer.

1997 • 295 citations

Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation.

1999 • 285 citations

Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors.

1997 • 273 citations

Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation

1998 • 266 citations

Hypermethylation of the p15INK4B Gene in Myelodysplastic Syndromes

1997 • 260 citations

Inactivation of the von Hippel–Lindau ( VHL ) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL ‐independent pathway in clear cell renal tumourigenesis

1998 • 255 citations

The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas

1997 • 254 citations

Hypermethylation of the DAP-Kinase CpG Island Is a Common Alteration in B-Cell Malignancies

1999 • 248 citations

Aberrant methylation of the BRCA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells

1998 • 245 citations

Hypermethylation of the p16INK4a promoter in colectomy specimens of patients with long-standing and extensive ulcerative colitis.

1998 • 237 citations

Methylation of the androgen receptor promoter CpG island is associated with loss of androgen receptor expression in prostate cancer cells.

1998 • 234 citations

Inactivation of p16 in Human Mammary Epithelial Cells by CpG Island Methylation

1998 • 231 citations

Detailed methylation analysis of the glutathione S-transferase π (GSTP1) gene in prostate cancer

1999 • 225 citations

Causes and consequences of microsatellite instability in endometrial carcinoma.

1999 • 217 citations

Somatic inactivation of the VHL gene in Von Hippel-Lindau disease tumors.

1997 • 217 citations

DNA methylation patterns of the calcitonin gene in human lung cancers and lymphomas.

1986 • 215 citations

CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine.

1995 • 215 citations

Methylation of Discrete Regions of the O⁶-Methylguanine DNA Methyltransferase (MGMT) CpG Island Is Associated with Heterochromatinization of the MGMT Transcription Start Site and Silencing of the Gene

1997 • 214 citations

Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene.

1997 • 214 citations

Inactivation of the von Hippel–Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for aVHL-independent pathway in clear cell renal tumourigenesis

1998 • 212 citations

Mapping of ER gene CpG island methylation-specific polymerase chain reaction.

1998 • 209 citations

DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene

1997 • 207 citations

p16INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas.

1997 • 197 citations

Frequent Hypermethylation of p16 and p15 Genes in Multiple Myeloma

1997 • 195 citations

CpG methylation within the 5′ regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site

1998 • 192 citations

Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation.

1999 • 191 citations

Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features☆, ☆☆

1999 • 186 citations

Methylation and silencing of the Thrombospondin-1 promoter in human cancer

1999 • 172 citations

Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells.

1998 • 158 citations

The estrogen receptor CpG island is methylated in most hematopoietic neoplasms.

1996 • 156 citations

Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia.

1997 • 150 citations

Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, Hurthle's cell, and poorly differentiated human thyroid carcinoma.

1998 • 150 citations

Mechanisms of inactivation of E-cadherin in breast cancer cell lines.

1998 • 148 citations

Methylation of the 5' CpG island of the FHIT gene is closely associated with transcriptional inactivation in esophageal squamous cell carcinomas.

1998 • 145 citations

Methylation of the 5' CpG island of the endothelin B receptor gene is common in human prostate cancer.

1997 • 143 citations

Methylation of the CD44 metastasis suppressor gene in human prostate cancer.

1999 • 143 citations

Hypermethylation in the retinoblastoma gene is associated with unilateral, sporadic retinoblastoma

1997 • 142 citations

Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region

1998 • 135 citations

Low frequency of p16/CDKN2A methylation in sporadic melanoma: comparative approaches for methylation analysis of primary tumors.

1997 • 129 citations

Loss of p16/INK4A Protein Expression in Non-Hodgkin's Lymphomas Is a Frequent Finding Associated with Tumor Progression

1998 • 125 citations

Independent induction of senescence by p16INK4a and p21CIP1 in spontaneously immortalized human fibroblasts.

1998 • 123 citations

Extensive intra- and interindividual heterogeneity of p15INK4B methylation in acute myeloid leukemia.

1999 • 121 citations

Absence of methylation of CpG dinucleotides within the promoter of the breast cancer susceptibility gene BRCA2 in normal tissues and in breast and ovarian cancers

1997 • 102 citations

Demethylation by 5-aza-2??-deoxycytidine of specific 5-methylcytosine sites in the promoter region of the retinoic acid receptor ?? gene in human colon carcinoma cells

1998 • 99 citations

p16/INK4a and p15/INK4b Gene Methylation and Absence of p16/INK4a mRNA and Protein Expression in Burkitt's Lymphoma

1998 • 89 citations

Hypermethylation of a 5′ CpG island of p16 is a frequent event in non-Hodgkin’s lymphoma

1997 • 86 citations

A cis-acting element accounts for a conserved methylation pattern upstream of the mouse adenine phosphoribosyltransferase gene.

1993 • 78 citations

A specific CpG methylation pattern of theMGMT promoter region associated with reduced MGMT expression in primary colorectal cancers

1999 • 78 citations

Abnormal methylation of the calcitonin gene marks progression of chronic myelogenous leukemia

1991 • 77 citations

Abnormal methylation of the calcitonin gene in human colonic neoplasms.

1989 • 75 citations

Methylation-mediated regulation of the glutathione S-transferase P1 gene in human breast cancer cells

1998 • 74 citations

Selective variegated methylation of thep15 CpG island in acute myeloid leukemia

1998 • 71 citations

Microsatellite instability and mismatch repair gene inactivation in sporadic pancreatic and colon tumours

1999 • 60 citations

Aberrant Silencing of the CpG Island-Containing Human O⁶-Methylguanine DNA Methyltransferase Gene Is Associated with the Loss of Nucleosome-Like Positioning

1997 • 58 citations

Down-regulation of CD44 expression in human prostatic carcinoma cell lines is correlated with DNA hypermethylation

1999 • 55 citations

Acceleration of chronic myeloid leukemia correlates with calcitonin gene hypermethylation

1991 • 54 citations

Methylation of the p16^INK4A gene in multiple myeloma

1998 • 53 citations

Frequent allelic loss at chromosome arm 3p is distinct from genetic alterations of the Von-Hippel Lindau tumor suppressor gene in head and neck cancer.

1996 • 46 citations

Acceleration of chronic myeloid leukemia correlates with calcitonin gene hypermethylation

1991 • 39 citations

Aberrant hypermethylation at the bcl-2 locus at 18q21 in human lung cancers.

1996 • 26 citations