Somatic inactivation of the VHL gene in Von Hippel-Lindau disease tumors.

Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene

1993 • 2,906 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Mutations of the VHL tumour suppressor gene in renal carcinoma

1994 • 1,719 citations

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 • 1,542 citations

Clinical Features and Natural History of von Hippel-Lindau Disease

1990 • 916 citations

Tumor suppressor genes

1991 • 775 citations

Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C

1995 • 672 citations

Inhibition of Transcription Elongation by the VHL Tumor Suppressor Protein

1995 • 571 citations

Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: Correlations with phenotype

1995 • 552 citations

Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas.

1994 • 469 citations

DNA methylation and cancer

1994 • 418 citations

Identification of intragenic mutations in the Von Hippel — Lindau disease tumour suppressor gene andcorrelation with disease phenotype

1994 • 386 citations

Somatic mutations of the von Hippel — Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma

1994 • 371 citations

Elongin (SIII): A Multisubunit Regulator of Elongation by RNA Polymerase II

1995 • 320 citations

Phenotypic expression in von Hippel-Lindau disease: correlations with germline VHL gene mutations.

1996 • 224 citations

Somatic mutations of the von Hippel-Lindau tumor suppressor gene in sporadic central nervous system hemangioblastomas.

1994 • 214 citations

Von Hippel-Lindau (VHL) disease with pheochromocytoma in the Black Forest region of Germany: evidence for a founder effect

1995 • 177 citations

Mutations in the RET proto-oncogene and the von Hippel-Lindau disease tumour suppressor gene in sporadic and syndromic phaeochromocytomas.

1995 • 171 citations

Molecular genetic investigations of the mechanism of tumourigenesis in von Hippel-Lindau disease: analysis of allele loss in VHL tumours

1994 • 150 citations

Molecular genetic diagnosis of von Hippel-Lindau disease in familial phaeochromocytoma.

1995 • 103 citations

Consequences of Direct Genetic Testing for Germline Mutations in the Clinical Management of Families With Multiple Endocrine Neoplasia, Type II

1995 • 103 citations

Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines.

1994 • 96 citations

Cytogenetic and fluorescence in situ hybridization studies on sporadic and hereditary tumors associated with von Hippel-Lindau syndrome (VHL)

1994 • 24 citations

A PCR generated AccI RFLP in the 3′ untranslated region of the von Hippel — Lindau disease (VHL) tumour suppressor gene

1994 • 22 citations