Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group [see comments]

1994 • 6,495 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

1997 • 1,636 citations

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

1995 • 1,353 citations

p73 is a human p53-related protein that can induce apoptosis

1997 • 951 citations

p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.

1991 • 915 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

1998 • 640 citations

Acute Myelogenous Leukemia: A Human Cell Line Responsive to Colony-Stimulating Activity

1978 • 537 citations

Rearrangement of the p53 gene in human osteogenic sarcomas.

1987 • 489 citations

p73 Function Is Inhibited by Tumor-Derived p53 Mutants in Mammalian Cells

1999 • 418 citations

Frequent Mutations in the p53 Tumor Suppressor Gene in Human Leukemia T-Cell Lines

1990 • 296 citations

Mutations of the p53 Gene as a Prognostic Factor in Aggressive B-Cell Lymphoma

1997 • 281 citations

Loss of alleles from the distal short arm of chromosome 1 occurs late in melanoma tumor progression.

1989 • 220 citations

Frequent Hypermethylation of p16 and p15 Genes in Multiple Myeloma

1997 • 195 citations

Activation of p73 silent allele in lung cancer.

1998 • 187 citations

Biochemical properties and biological effects of p53

1995 • 183 citations

Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers.

1998 • 178 citations

Homozygous deletions of the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia

1995 • 175 citations

Preferential germline mutation of the paternal allele in retinoblastoma

1989 • 169 citations

Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A, and p18 genes in acute lymphoblastic leukemia of childhood

1995 • 158 citations

Rearrangements in the p53 gene in Philadelphia chromosome positive chronic myelogenous leukemia [see comments]

1989 • 157 citations

Mutation, allelotyping, and transcription analyses of the p73 gene in prostatic carcinoma.

1998 • 143 citations

Loss of p16/INK4A Protein Expression in Non-Hodgkin's Lymphomas Is a Frequent Finding Associated with Tumor Progression

1998 • 125 citations

Clinical significance of p53 mutations in relapsed T-cell acute lymphoblastic leukemia

1994 • 121 citations

Characterization of a novel HTLV-infected cell line

1984 • 116 citations

Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic features

1995 • 114 citations

Clinical outcome in diffuse large B-cell lymphoma is dependent on the relationship between different cell-cycle regulator proteins.

1998 • 104 citations

Increased expression of p53 protein in human leukemia cells.

1986 • 94 citations

Inactivation of the retinoblastoma gene in human lymphoid neoplasms

1991 • 91 citations

Lonely No More: p53 Finds Its Kin in a Tumor Suppressor Haven

1997 • 83 citations

Chromosome Band 1p36 Contains a Putative Tumor Suppressor Gene Important in the Evolution of Chronic Myelocytic Leukemia

1998 • 78 citations

Hypermethylation of the CpG island of p16/CDKN2 correlates with gene inactivation in gliomas.

1996 • 65 citations

Preferential amplification of the paternal allele of the N–myc gene in human neuroblastomas

1993 • 62 citations

Methylation of the p16^INK4A gene in multiple myeloma

1998 • 53 citations

Hypomethylation and increased gene expression of p16INK4a in primary and metastatic breast carcinoma as compared to normal breast tissue

1998 • 47 citations

Transcriptional silencing of the p16 gene in human myeloma-derived cell lines by hypermethylation.

1998 • 42 citations

Expression and prognostic value of the retinoblastoma tumour suppressor gene (RB‐1) in childhood acute lymphoblastic leukaemia

1996 • 22 citations