Low circulating regulatory T-cell levels after acute rejection in liver transplantation

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.

1996 • 1,335 citations

Regulatory T cells in transplantation tolerance

2003 • 1,323 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

2003 • 1,252 citations

Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT3 and ILT4

2002 • 800 citations

IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

2001 • 799 citations

Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells.

1996 • 788 citations

CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses

2002 • 766 citations

Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

1999 • 762 citations

Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function

2002 • 630 citations

Regulatory T Cells Induced by 1α,25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance

2001 • 627 citations

Dysfunctional Blood and Target Tissue CD4+CD25high Regulatory T Cells in Psoriasis: Mechanism Underlying Unrestrained Pathogenic Effector T Cell Proliferation

2005 • 561 citations

Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection

2005 • 500 citations

Both CD4+CD25+ and CD4+CD25− Regulatory Cells Mediate Dominant Transplantation Tolerance

2002 • 372 citations

Suppression of HCV-specific T cells without differential hierarchy demonstrated in persistent HCV infection

2003 • 357 citations

Analyses of Peripheral Blood Mononuclear Cells in Operational Tolerance After Pediatric Living Donor Liver Transplantation

2004 • 263 citations

Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells

2002 • 246 citations

Defining the outcome of immunosuppression withdrawal after liver transplantation

1998 • 237 citations

Weaning Of Immunosuppression In Long-Term Liver Transplant Recipients

1995 • 234 citations

Differential Effect of Calcineurin Inhibitors, Anti-CD25 Antibodies and Rapamycin on the Induction of FOXP3 in Human T Cells

2005 • 220 citations

The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade

2003 • 180 citations

DIFFERENTIAL EFFECTS OF CYCLOSPORINE A, METHYLPREDNISOLONE, MYCOPHENOLATE, AND RAPAMYCIN ON CD154 INDUCTION AND REQUIREMENT FOR NF??B

2000 • 161 citations

Tolerance to rat liver allografts. III. Donor cell migration and tolerance-associated cytokine production in peripheral lymphoid tissues.

1996 • 142 citations

Incidence of rejection and infection after liver transplantation as a function of the primary disease: Possible influence of alcohol and polyclonal immunoglobulins

1996 • 138 citations

Incidence of rejection and infection after liver transplantation as a function of the primary disease: Possible influence of alcohol and polyclonal immunoglobulins

1996 • 129 citations

Regulatory CD8+CD28− T cells in heart transplant recipients

2002 • 117 citations

Detection of T suppressor cells in patients with organ allografts

2001 • 81 citations

A SHORT COURSE OF METHYLPREDNISOLONE IMMUNOSUPPRESSION INHIBITS BOTH REJECTION AND SPONTANEOUS ACCEPTANCE OF RAT LIVER ALLOGRAFTS

2001 • 61 citations

Effects of Immunosuppressants on Induction of Regulatory Cells After Intratracheal Delivery of Alloantigen

2005 • 44 citations

Decrease of CD4+CD25+ T Cells in Peripheral Blood After Liver Transplantation: Association With Immunosuppression

2005 • 39 citations

Regulatory T cells: potential in organ transplantation.1

2004 • 37 citations

Mutual tolerance after liver and not after heart transplantation? Evaluation of patient-anti-donor and donor-anti-patient responses by mixed lymphocyte culture

1998 • 8 citations