TGF-β Requires CTLA-4 Early after T Cell Activation to Induce FoxP3 and Generate Adaptive CD4+CD25+ Regulatory Cells

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Natural versus adaptive regulatory T cells

2003 • 1,363 citations

Modulation of tryptophan catabolism by regulatory T cells

2003 • 1,323 citations

CTLA-4–Ig regulates tryptophan catabolism in vivo

2002 • 1,150 citations

Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7

2004 • 1,123 citations

CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy

2001 • 964 citations

Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

2004 • 805 citations

Natural and Induced CD4+CD25+ Cells Educate CD4+CD25− Cells to Develop Suppressive Activity: The Role of IL-2, TGF-β, and IL-10

2004 • 657 citations

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

2005 • 591 citations

Prostaglandin E2 Induces FOXP3 Gene Expression and T Regulatory Cell Function in Human CD4+ T Cells

2005 • 553 citations

A Role for TGF-β in the Generation and Expansion of CD4+CD25+ Regulatory T Cells from Human Peripheral Blood

2001 • 540 citations

Imaging the Single Cell Dynamics of CD4+ T Cell Activation by Dendritic Cells in Lymph Nodes

2004 • 537 citations

TGF-β Induces Foxp3 + T-Regulatory Cells from CD4 + CD25 − Precursors

2004 • 527 citations

Cytotoxic T Lymphocyte Antigen-4 Accumulation in the Immunological Synapse Is Regulated by TCR Signal Strength

2002 • 497 citations

T cell fitness determined by signal strength

2003 • 478 citations

Generation Ex Vivo of TGF-β-Producing Regulatory T Cells from CD4+CD25− Precursors

2002 • 461 citations

Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: Twelve‐month results of a phase iib, double‐blind, randomized, placebo‐controlled trial

2005 • 446 citations

TGF-β regulatesin vivoexpansion of Foxp3-expressing CD4⁺CD25⁺regulatory T cells responsible for protection against diabetes

2004 • 425 citations

B7-1 and B7-2 Selectively Recruit CTLA-4 and CD28 to the Immunological Synapse

2004 • 415 citations

Distinct roles of CTLA‐4 and TGF‐β in CD4⁺CD25⁺ regulatory T cell function

2004 • 377 citations

Duration of TCR Stimulation Determines Costimulatory Requirement of T Cells

1996 • 372 citations

Engagement of Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Induces Transforming Growth Factor β (TGF-β) Production by Murine CD4+ T Cells

1998 • 359 citations

The main function of IL-2 is to promote the development of T regulatory cells

2003 • 323 citations

Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease

2004 • 322 citations

The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation

2004 • 297 citations

CD86 and CD80 Differentially Modulate the Suppressive Function of Human Regulatory T Cells

2004 • 275 citations

CD4+ and CD8+ Regulatory T Cells Generated Ex Vivo with IL-2 and TGF-β Suppress a Stimulatory Graft-versus-Host Disease with a Lupus-Like Syndrome

2004 • 237 citations

Structural Analysis of CTLA-4 Function In Vivo

2000 • 236 citations

Differentiation and Expansion of T Cells with Regulatory Function from Human Peripheral Lymphocytes by Stimulation in the Presence of TGF-β

2005 • 173 citations

The role of transforming growth factor beta in the generation of suppression: an interaction between CD8+ T and NK cells.

1994 • 147 citations

Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25+ regulatory T cells

2002 • 137 citations

CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X(L) induction.

1998 • 137 citations

Acquisition of anergic and suppressive activities in transforming growth factor- -costimulated CD4+CD25- T cells

2004 • 116 citations

Regulatory/suppressor T cells in health and disease

2004 • 112 citations

Cutting Edge: CTLA-4 Ligation Delivers a Unique Signal to Resting Human CD4 T Cells That Inhibits Interleukin-2 Secretion but Allows Bcl-XL Induction

1998 • 111 citations

The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance

2002 • 106 citations

Suppressor and oncogenic roles of transforming growth factor-β and its signaling pathways in tumorigenesis

2001 • 97 citations

TGF-β signaling in T cells: roles in lymphoid and epithelial neoplasia

2005 • 82 citations

Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4+CD25+ cells in the recipient

2006 • 79 citations

B7-Independent Inhibition of T Cells by CTLA-4

2005 • 74 citations

Targeted CTLA-4 Engagement Induces CD4+CD25+CTLA-4high T Regulatory Cells with Target (Allo)antigen Specificity

2004 • 65 citations

Lack of a role for transforming growth factor-β in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation

2001 • 57 citations

Interleukin-2 Signaling and the Maintenance of Self-Tolerance

2001 • 54 citations

Re-establishing Peripheral Tolerance in the Absence of CTLA-4: Complementation by Wild-Type T Cells Points to an Indirect Role for CTLA-4

2002 • 51 citations

Generation of Antigen-Specific, Foxp3-Expressing CD4+ Regulatory T Cells by Inhibition of APC Proteosome Function

2005 • 50 citations

Importance of IL-10 for CTLA-4-Mediated Inhibition of Tumor-Eradicating Immunity

2004 • 47 citations

Biphasic role of TGF‐β1 in signal transduction and crosstalk

2003 • 47 citations

Cyclic Adenosine 5′-Monophosphate and Calcium Induce CD152 (CTLA-4) Up-Regulation in Resting CD4+ T Lymphocytes

2002 • 45 citations

Smad-dependent Cooperative Regulation of Interleukin 2 Receptor α Chain Gene Expression by T Cell Receptor and Transforming Growth Factor-β

2005 • 43 citations

Simultaneous blockade of co-stimulatory signals, CD28 and ICOS, induced a stable tolerance in rat heart transplantation

2003 • 33 citations

Transforming growth factor β enhances the expression of CD154 (CD40L) and production of tumor necrosis factor α by human T lymphocytes

2001 • 23 citations

Down-Regulation of IL-2 Production in T Lymphocytes by Phosphorylated Protein Kinase A-RIIβ

2004 • 15 citations

MHC class II-independent and -dependent T cell expansion and B cell hyperactivity in vivo in mice deficient in CD152 (CTLA-4)

2004 • 10 citations

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