Bombesin and bombesin antagonists: Studies in Swiss 3T3 cells and human small cell lung cancer

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System

1985 • 1,585 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer

1985 • 1,360 citations

Isolation and structure of bombesin and alytesin, two analogous active peptides from the skin of the european amphibiansBombina andAlytes

1971 • 917 citations

Growth factors: Mechanism of action and relation to oncogenes

1984 • 885 citations

Characterization of a gastrin releasing peptide from porcine non-antral gastric tissue

1979 • 871 citations

cDNA eloping of bovine substance-K receptor through oocyte expression system

1987 • 748 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

Receptor-mediated endocytosis

1985 • 577 citations

High Levels of Intracellular Bombesin Characterize Human Small-Cell Lung Carcinoma

1981 • 492 citations

Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells.

1983 • 470 citations

Bombesin-like immunoreactivity in the lung

1978 • 439 citations

Progress against Cancer?

1986 • 420 citations

Fate of immunoprecipitable protein kinase C in GH3 cells treated with phorbol 12-myristate 13-acetate.

1985 • 387 citations

POLYPEPTIDE GROWTH FACTORS

1984 • 381 citations

Phorbol esters, phospholipase C, and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiescent 3T3 cells.

1983 • 377 citations

Neuromedin B: A novel bombesin-like peptide identified in porcine spinal cord

1983 • 372 citations

Peptide growth factors and inflammation, tissue repair, and cancer.

1986 • 360 citations

Growth factor-stimulated protein phosphorylation in 3T3-L1 cells. Evidence for protein kinase C-dependent and -independent pathways.

1985 • 351 citations

Phorbol esters and vasopressin stimulate DNA synthesis by a common mechanism

1980 • 334 citations

Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms

1986 • 325 citations

Protein kinase C-stimulated phosphorylation in vitro of a Mr 80,000 protein phosphorylated in response to phorbol esters and growth factors in intact fibroblasts. Distinction from protein kinase C and prominence in brain.

1986 • 277 citations

Selective stimulation of small cell lung cancer clonal growth by bombesin and gastrin-releasing peptide

1987 • 269 citations

Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 cells: role of Ca2+-sensitive phospholipid-dependent protein kinase.

1984 • 266 citations

Cloning and characterization of cDNAs encoding human gastrin-releasing peptide.

1984 • 239 citations

Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. I. Activation of protein kinase C and inhibition of epidermal growth factor binding.

1986 • 225 citations

A role for neuropeptides in the control of cell proliferation

1987 • 225 citations

Neuromedin C: A bombesin-like peptide identified in porcine spinal cord

1984 • 223 citations

Gastrin releasing peptide is a selective mitogen for small cell lung carcinoma in vitro.

1985 • 216 citations

Selective growth in serum-free hormone-supplemented medium of tumor cells obtained by biopsy from patients with small cell carcinoma of the lung.

1981 • 208 citations

Peptide Hormone-Induced Receptor Mobility, Aggregation, and Internalization

1981 • 207 citations

High-affinity receptors for peptides of the bombesin family in Swiss 3T3 cells.

1985 • 202 citations

Reduction of epidermal growth factor receptor affinity by heterologous ligands: Evidence for a mechanism involving the breakdown of phosphoinositides and the activation of protein kinase C

1984 • 197 citations

BOMBESIN,SOMATOSTATIN AND NEUROTENSIN-LIKE IMMUNOREACTIVITY IN BRONCHIAL CARCINOMA

1981 • 186 citations

Effects of bombesin and insulin on inositol (1,4,5) trisphosphate and inositol (1,3,4) trisphosphate formation in Swiss 3T3 cells

1986 • 185 citations

Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs.

1986 • 184 citations

Human lung small-cell carcinoma contains bombesin.

1982 • 184 citations

The effects of bombesin on polyphosphoinositide and calcium metabolism in Swiss 3T3 cells.

1987 • 175 citations

A synthetic peptide that is a bombesin receptor antagonist

1984 • 171 citations

Pertussis Toxin-Sensitive Pathway in the Stimulation of c- myc Expression and DNA Synthesis by Bombesin

1986 • 171 citations

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro.

1988 • 170 citations

Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. II. Changes in Na+ and Ca2+ fluxes, Na+/K+ pump activity, and intracellular pH.

1986 • 164 citations

Uptake of Insulin and Other Ligands into Receptor-Rich Endocytic Components of Target Cells: The Endosomal Apparatus

1985 • 163 citations

Production and molecular size heterogeneity of immunoreactive gastrin-releasing peptide in fetal and adult lungs and primary lung tumors.

1983 • 151 citations

Phosphorylation of an acidic mol. wt. 80 000 cellular protein in a cell-free system and intact Swiss 3T3 cells: a specific marker of protein kinase C activity.

1986 • 147 citations

Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin-related peptide, gastrin-releasing peptide.

1986 • 132 citations

Transient elevation of messenger RNA encoding gastrin-releasing peptide, a putative pulmonary growth factor in human fetal lung.

1987 • 128 citations

Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: Evidence for a role of protein kinase C

1987 • 127 citations

Ca2+-mobilizing actions of platelet-derived growth factor differ from those of bombesin and vasopressin in Swiss 3T3 mouse cells.

1987 • 126 citations

Growth factors, oncogenes, and multistage carcinogenesis

1987 • 121 citations

Identification of a receptor for peptides of the bombesin family in Swiss 3T3 cells by affinity cross-linking.

1987 • 114 citations

Quantitation of protein kinase C by immunoblot—expression in different cell lines and response to phorbol esters

1987 • 114 citations

Serum, like phorbol esters, rapidly activates protein kinase C in intact quiescent fibroblasts.

1985 • 110 citations

Protein kinase C activation enhances cAMP accumulation in Swiss 3T3 cells: inhibition by pertussis toxin.

1987 • 100 citations

Ionic responses rapidly elicited by activation of protein kinase C in quiescent Swiss 3T3 cells.

1985 • 91 citations

Bombesin and Vasoactive Intestinal Polypeptide in the Developing Lung: Marked Changes in Acute Respiratory Distress Syndrome*

1983 • 84 citations

Receptor for bombesin with associated tyrosine kinase activity.

1986 • 77 citations

Bombesin induction of c‐fos and c‐myc proto‐oncogenes in Swiss 3T3 cells: Significance for the mitogenic response

1987 • 77 citations

Inhibition of bombesin-induced mitogenesis by pertussis toxin: Dissociation from phospholipase C pathway

1987 • 76 citations

A peptide that inhibits the mitogenic stimulation of Swiss 3T3 cells by bombesin or vasopressin

1985 • 75 citations

Peptide Hormone Antagonists That Are Effective in Vivo

1986 • 69 citations

Modulation of the epidermal growth factor receptor by mitogenic ligands: effects of bombesin and role of protein kinase C.

1985 • 69 citations

Growth factors in biology and medicine

1986 • 64 citations

Return of the magnificent seven

1987 • 60 citations

Growth factors, cell proliferation and cancer: an overview.

1983 • 52 citations

Stabilized complexes of epidermal growth factor and its receptor on the cell surface stimulate RNA synthesis but not mitogenesis.

1985 • 51 citations

Internalization and degradation of peptides of the bombesin family in Swiss 3T3 cells occurs without ligand-induced receptor down-regulation.

1987 • 50 citations

cDNA cloning of bovine substance-K receptor through oocyte expression system

1989 • 49 citations

Bombesin stimulation of c-fos and c-myc gene expression in cultures of Swiss 3T3 cells

1986 • 48 citations

Neuromedin B-32 and B-30: Two “big” neuromedin B identified in porcine brain and spinal cord

1985 • 46 citations

Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer

1986 • 45 citations

A substance P antagonist also inhibits specific binding and mitogenic effects of vasopressin and bombesin-related peptides in Swiss 3T3 cells

1986 • 43 citations

Characterisation of bombesin-like immunoreactivity in human fetal lung

1983 • 35 citations

Progress against Cancer?

1986 • 33 citations

Protein Phosphorylation in a Tetradecanoyl Phorbol Acetate-Nonproliferative Variant of 3T3 Cells

1985 • 31 citations

Polypeptide Growth Factors

1984 • 27 citations

Protein phosphorylation in a tetradecanoyl phorbol acetate-nonproliferative variant of 3T3 cells.

1985 • 19 citations

Detection of Gastrin-Releasing Peptide mRNA in Small Cell Lung Carcinomas and Medullary Thyroid Carcinomas Using Synthetic Oligodeoxyribonucleotide Probes

1987 • 16 citations

Receptor for Bombesin with Associated Tyrosine Kinase Activity

1986 • 14 citations

Peptide Growth Factors and Inflammation, Tissue Repair, and Cancer

1987 • 8 citations

Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs

1987 • 8 citations

Uptake of Insulin and Other Ligands into Receptor-Rich Endocytic Components of Target Cells: The Endosomal Apparatus

1985 • 7 citations

Molecular analysis of the expression of mammalian prepro-gastrin releasing peptide genes

1987 • 1 citations