Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

A simple and very efficient method for generating cDNA libraries

1983 • 4,606 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination

1977 • 3,548 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products

1982 • 2,114 citations

Efficient isolation of genes by using antibody probes.

1983 • 2,065 citations

Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer

1985 • 1,360 citations

Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genes

1981 • 959 citations

Charon Phages: Safer Derivatives of Bacteriophage Lambda for DNA Cloning

1977 • 951 citations

Establishment and identification of small cell lung cancer cell lines having classic and variant features

1986 • 896 citations

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

1980 • 880 citations

Characterization of a gastrin releasing peptide from porcine non-antral gastric tissue

1979 • 871 citations

The human c-myc oncogene: Structural consequences of translocation into the igh locus in Burkitt lymphoma

1983 • 732 citations

Three different fibronectin mRNAs arise by alternative splicing within the coding region

1983 • 713 citations

High Levels of Intracellular Bombesin Characterize Human Small-Cell Lung Carcinoma

1981 • 492 citations

Characterization of variant subclasses of cell lines derived from small cell lung cancer having distinctive biochemical, morphological, and growth properties.

1985 • 472 citations

Bombesin-like immunoreactivity in the lung

1978 • 439 citations

Neuroendocrine components of the bronchopulmonary tract: hyperplasias, dysplasias, and neoplasms.

1983 • 389 citations

Neuromedin B: A novel bombesin-like peptide identified in porcine spinal cord

1983 • 372 citations

The isolation and sequence of the gene encoding T8: A molecule defining functional classes of T lymphocytes

1985 • 325 citations

Cloning and characterization of cDNAs encoding human gastrin-releasing peptide.

1984 • 239 citations

Characterization of the branch site in lariat RNAs produced by splicing of mRNA precursors

1985 • 232 citations

Studies on the bronchial counterpart of the Kultschitzky (Argentaffin) cell and innervation of bronchial glands

1965 • 228 citations

Gastrin releasing peptide is a selective mitogen for small cell lung carcinoma in vitro.

1985 • 216 citations

Active polypeptides of the amphibian skin and their synthetic analogues

1973 • 203 citations

Bombesin-like activity: Radioimmunologic assessment in biological tissues

1978 • 197 citations

BOMBESIN,SOMATOSTATIN AND NEUROTENSIN-LIKE IMMUNOREACTIVITY IN BRONCHIAL CARCINOMA

1981 • 186 citations

Human lung small-cell carcinoma contains bombesin.

1982 • 184 citations

The Endocrine Lung in Health and Disease

1985 • 160 citations

Production and molecular size heterogeneity of immunoreactive gastrin-releasing peptide in fetal and adult lungs and primary lung tumors.

1983 • 151 citations

High capacity gel preparative electrophoresis for purification of fragments of genomic DNA

1978 • 128 citations

Bombesin production by human small cell carcinoma of the lung

1982 • 100 citations

Bombesin-like peptides in small cell lung cancer: Biochemical characterization and secretion from a cell line

1983 • 76 citations

Regional distribution of bombesin and seven other regulatory peptides in the human brain

1984 • 68 citations

Pulmonary carcinoids. Immunohistochemical demonstration of brain-gut peptides

1983 • 47 citations

5' sequence of porcine and rat pro-opiomelanocortin mRNA. One porcine and two rat forms.

1984 • 46 citations

Gastrin-releasing peptide, a mammalian analog of bombesin, is present in human neuroendocrine lung tumors.

1984 • 35 citations

Effects of aurintricarboxylic acid on ribosomes and the biosynthesis of globin in rabbit reticulocytes.

1972 • 32 citations

Peripheral lung carcinoid tumor producing predominantly gastrin-releasing peptide (GRP) morphologic and hormonal studies

1983 • 32 citations