Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin-related peptide, gastrin-releasing peptide.

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1980 • 2,387 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer

1985 • 1,360 citations

Epidermal Growth Factor and a New Derivative

1972 • 1,225 citations

Isolation and structure of bombesin and alytesin, two analogous active peptides from the skin of the european amphibiansBombina andAlytes

1971 • 917 citations

Characterization of a gastrin releasing peptide from porcine non-antral gastric tissue

1979 • 871 citations

Two dimensional gel electrophoresis and computer analysis of proteins synthesized by clonal cell lines.

1979 • 759 citations

Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells

1981 • 669 citations

Tyr ⁵²⁷ Is Phosphorylated in pp60 ^{c- src} : Implications for Regulation

1986 • 567 citations

Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus

1980 • 560 citations

The phorbol ester receptor: a phospholipid-regulated protein kinase

1985 • 522 citations

Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses

1983 • 518 citations

Early changes in phosphatidylinositol and arachidonic acid metabolism in quiescent swiss 3T3 cells stimulated to divide by platelet-derived growth factor.

1981 • 492 citations

High Levels of Intracellular Bombesin Characterize Human Small-Cell Lung Carcinoma

1981 • 492 citations

Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells.

1983 • 470 citations

Platelet-derived growth factor. I. High yield purification and evidence for multiple forms.

1982 • 457 citations

Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells.

1981 • 440 citations

Phorbol esters, phospholipase C, and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiescent 3T3 cells.

1983 • 377 citations

Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins

1982 • 366 citations

Bombesin and the C-terminal tetradecapeptide of gastrin-releasing peptide are growth factors for normal human bronchial epithelial cells

1984 • 354 citations

Growth factor-stimulated protein phosphorylation in 3T3-L1 cells. Evidence for protein kinase C-dependent and -independent pathways.

1985 • 351 citations

c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF

1985 • 331 citations

Transformation by Rous sarcoma virus: effects of src gene expression on the synthesis and phosphorylation of cellular polypeptides.

1979 • 293 citations

Protein kinase C-stimulated phosphorylation in vitro of a Mr 80,000 protein phosphorylated in response to phorbol esters and growth factors in intact fibroblasts. Distinction from protein kinase C and prominence in brain.

1986 • 277 citations

I. High affinity receptors for bombesin/GRP-like peptides on human small cell lung cancer

1985 • 251 citations

Protein kinase C phosphorylates pp60src at a novel site

1985 • 243 citations

Comparison of the expression of the src gene of Rous sarcoma virus in vitro and in vivo

1978 • 229 citations

Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. I. Activation of protein kinase C and inhibition of epidermal growth factor binding.

1986 • 225 citations

Gastrin releasing peptide is a selective mitogen for small cell lung carcinoma in vitro.

1985 • 216 citations

Phorbol ester and diacylglycerol induce protein phosphorylation at tyrosine

1983 • 214 citations

The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor.

1985 • 207 citations

Inhibition of epidermal growth factor binding to surface receptors by tumor promotors

1979 • 206 citations

High-affinity receptors for peptides of the bombesin family in Swiss 3T3 cells.

1985 • 202 citations

Reduction of epidermal growth factor receptor affinity by heterologous ligands: Evidence for a mechanism involving the breakdown of phosphoinositides and the activation of protein kinase C

1984 • 197 citations

Bombesin, bombesin analogs, and related peptides: effects on thermoregulation

1978 • 186 citations

Human lung small-cell carcinoma contains bombesin.

1982 • 184 citations

Binding of phorbol esters to high‐affinity sites on murine fibroblastic cells elicits a mitogenic response

1982 • 167 citations

Regulation of Cell Growth and Transformation by Tyrosine-Specific Protein Kinases: The Search for Important Cellular Substrate Proteins

1983 • 164 citations

Diverse Mitogenic Agents Induce the Phosphorylation of Two Related 42,000-Dalton Proteins on Tyrosine in Quiescent Chick Cells

1984 • 159 citations

Changes in Protein Phosphorylation in Rous Sarcoma Virus-Transformed Chicken Embryo Cells

1981 • 158 citations

Homologous and heterologous mitogenic desensitization of Swiss 3T3 cells to phorbol esters and vasopressin: Role of receptor and postreceptor steps

1984 • 154 citations

Phosphorylation of an acidic mol. wt. 80 000 cellular protein in a cell-free system and intact Swiss 3T3 cells: a specific marker of protein kinase C activity.

1986 • 147 citations

Characterization of bombesin receptors in a rat pituitary cell line.

1983 • 129 citations

Serum, like phorbol esters, rapidly activates protein kinase C in intact quiescent fibroblasts.

1985 • 110 citations

Bombesin Stimulates Prolactin and Growth Hormone Release by Pituitary Cells in Culture*

1982 • 104 citations

The Effect of Bombesin and Related Peptides on Prolactin and Growth Hormone Secretion in the Rat*

1978 • 103 citations

Is gastrin releasing peptide mammalian bombesin?

1980 • 103 citations

A peptide that inhibits the mitogenic stimulation of Swiss 3T3 cells by bombesin or vasopressin

1985 • 75 citations

Modulation of p36 phosphorylation in human cells: studies using anti-p36 monoclonal antibodies.

1986 • 64 citations

Phosphatidylinositol turnover and transformation of cells by Abelson murine leukaemia virus.

1985 • 61 citations

Bombesin stimulates insulin secretion by a pancreatic islet cell line.

1984 • 60 citations

Major Substrate for Growth Factor-Activated Protein-Tyrosine Kinases Is a Low-Abundance Protein

1985 • 54 citations

In vivo phosphorylation and dephosphorylation of the platelet-derived growth factor receptor studied by immunoblot analysis with phosphotyrosine antibodies

1986 • 52 citations

Diacylglycerol treatment rapidly decreases the affinity of the epidermal growth factor receptors of Swiss 3T3 cells

1985 • 49 citations

Protein Phosphorylation in a Tetradecanoyl Phorbol Acetate-Nonproliferative Variant of 3T3 Cells

1985 • 31 citations

Novel serine phosphorylation of pp60c-src in intact cells after tumor promoter treatment.

1986 • 29 citations

Modulation of p36 Phosphorylation in Human Cells: Studies Using Anti-p36 Monoclonal Antibodies

1986 • 18 citations