Signal transduction during amyloid-β-peptide neurotoxicity: role in Alzheimer disease

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Alzheimer's Disease Is a Synaptic Failure

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An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

1998 • 3,404 citations

Wnt signaling and cancer

2000 • 3,215 citations

The Mechanisms of Action of PPARs

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β-catenin is a target for the ubiquitin–proteasome pathway

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A molecular mechanism for the effect of lithium on development.

1996 • 2,270 citations

Staging of alzheimer's disease-related neurofibrillary changes

1995 • 2,187 citations

Copper, iron and zinc in Alzheimer's disease senile plaques

1998 • 2,035 citations

Roles of PPARs in health and disease

2000 • 1,941 citations

Inhibition of Adipogenesis by Wnt Signaling

2000 • 1,822 citations

High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

2000 • 1,793 citations

MODELS OF AMYLOID SEEDING IN ALZHEIMER'S DISEASE AND SCRAPIE: Mechanistic Truths and Physiological Consequences of the Time-Dependent Solubility of Amyloid Proteins

1997 • 1,621 citations

Rapid induction of Alzheimer A beta amyloid formation by zinc

1994 • 1,483 citations

Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

2001 • 1,418 citations

Oligomeric and Fibrillar Species of Amyloid-β Peptides Differentially Affect Neuronal Viability

2002 • 1,405 citations

Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells

1996 • 1,299 citations

Peroxisome proliferator-activated receptor a target genes

2004 • 1,204 citations

PPARγ: a Nuclear Regulator of Metabolism, Differentiation, and Cell Growth

2001 • 1,147 citations

Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

1999 • 1,118 citations

The Cholinergic Hypothesis of Age and Alzheimer's Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development

2003 • 1,101 citations

PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs

1999 • 1,091 citations

Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme

1996 • 1,058 citations

Pain: Moving from Symptom Control toward Mechanism-Specific Pharmacologic Management

2004 • 1,046 citations

LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way

2004 • 990 citations

Dramatic Aggregation of Alzheimer Aβ by Cu(II) Is Induced by Conditions Representing Physiological Acidosis

1998 • 988 citations

Tau in Alzheimer's disease

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Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

1992 • 899 citations

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

2001 • 865 citations

Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds

1993 • 800 citations

Wnt genes

1992 • 799 citations

Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity

1999 • 748 citations

Regulation of Wnt Signaling during Adipogenesis

2002 • 712 citations

Axonal Remodeling and Synaptic Differentiation in the Cerebellum Is Regulated by WNT-7a Signaling

2000 • 686 citations

The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)

1996 • 657 citations

Activation of the Wnt Signaling Pathway: A Molecular Mechanism for Lithium Action

1997 • 627 citations

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

2000 • 617 citations

Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

1998 • 612 citations

β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding

1995 • 580 citations

The Wnt/β-catenin pathway directs neuronal differentiation of cortical neural precursor cells

2004 • 578 citations

Metalloenzyme-like Activity of Alzheimer's Disease β-Amyloid

2002 • 566 citations

Immunolocalization of peroxisome proliferator-activated receptors and retinoid x receptors in the adult rat CNS

2003 • 555 citations

Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons

1999 • 537 citations

Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

1998 • 512 citations

Alzheimer's disease – do tauists and baptists finally shake hands?

2002 • 504 citations

The Mood‐Stabilizing Agents Lithium and Valproate RobustlIncrease the Levels of the Neuroprotective Protein bcl‐2 in the CNS

1999 • 495 citations

Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β

2003 • 481 citations

Long Term Lithium Treatment Suppresses p53 and Bax Expression but Increases Bcl-2 Expression

1999 • 470 citations

Lithium Reduces Tau Phosphorylation by Inhibition of Glycogen Synthase Kinase-3

1997 • 459 citations

β-catenin is critical for dendritic morphogenesis

2003 • 450 citations

Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain

2004 • 434 citations

GATA-3 Is Involved in the Development of Serotonergic Neurons in the Caudal Raphe Nuclei

1999 • 411 citations

Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau

1998 • 404 citations

Alzheimer's disease and Aβ toxicity: from top to bottom

2001 • 396 citations

A detergent-insoluble membrance compartment contains Aβ in vivo

1998 • 394 citations

The Role of Insulin Resistance in the Pathogenesis of Alzheimer??s Disease

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A Structural Motif of Acetylcholinesterase That Promotes Amyloid β-Peptide Fibril Formation

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Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies

2004 • 384 citations

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

1993 • 379 citations

The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin

1998 • 373 citations

Anti-bipolar therapy: mechanism of action of lithium

1999 • 372 citations

Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver.

1993 • 371 citations

Spatial learning deficit in transgenic mice that conditionally over‐express GSK‐3β in the brain but do not form tau filaments

2002 • 360 citations

Copper Mediates Dityrosine Cross-Linking of Alzheimer's Amyloid-β

2003 • 352 citations

Distribution, Levels, and Activity of Glycogen Synthase Kinase-3 in the Alzheimer Disease Brain

1997 • 344 citations

Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by β-amyloid fibrils

2003 • 321 citations

The α-Helical to β-Strand Transition in the Amino-terminal Fragment of the Amyloid β-Peptide Modulates Amyloid Formation

1995 • 319 citations

Lithium inhibits Alzheimer's disease‐like tau protein phosphorylation in neurons

1997 • 315 citations

Roles of Wnt proteins in neural development and maintenance

2000 • 311 citations

Sequential phosphorylation of Tau by glycogen synthase kinase‐3β and protein kinase A at Thr212 and Ser214 generates the Alzheimer‐specific epitope of antibody AT100 and requires a paired‐helical‐filament‐like conformation

1998 • 308 citations

Role of β-Catenin in Synaptic Vesicle Localization and Presynaptic Assembly

2003 • 304 citations

Stable Complexes Involving Acetylcholinesterase and Amyloid-β Peptide Change the Biochemical Properties of the Enzyme and Increase the Neurotoxicity of Alzheimer’s Fibrils

1998 • 300 citations

Wnt signaling function in Alzheimer’s disease

2000 • 289 citations

Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons.

1996 • 289 citations

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Muscarinic acetylcholine receptor subtypes in cerebral cortex and hippocampus

2004 • 286 citations

Detection of a Novel Intraneuronal Pool of Insoluble Amyloid β Protein that Accumulates with Time in Culture

1998 • 285 citations

Muscarinic acetylcholine receptors in the hippocampus, neocortex and amygdala: a review of immunocytochemical localization in relation to learning and memory

1999 • 261 citations

Amyloid β Peptide of Alzheimer’s Disease Downregulates Bcl-2 and Upregulates Bax Expression in Human Neurons

1996 • 257 citations

Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats

1998 • 256 citations

Exposure of rat hippocampal neurons to amyloid β peptide (25–35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3β

1996 • 253 citations

Excess beta -catenin promotes accumulation of transcriptionally active p53

1999 • 236 citations

Loss of presenilin 1 is associated with enhanced β-catenin signaling and skin tumorigenesis

2001 • 231 citations

Zebrafishwnt8andwnt8bshare a common activity but are involved in distinct developmental pathways

1995 • 231 citations

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin,a component of the presenilin protein complex

1999 • 224 citations

Wnt Signaling to β-Catenin Involves Two Interactive Components

2000 • 220 citations

Stress‐Activated Protein Kinase/c‐Jun N‐Terminal Kinase Phosphorylates τ Protein

1997 • 213 citations

A divergent canonical WNT-signaling pathway regulates microtubule dynamics

2004 • 211 citations

A Cell Biological Perspective on Alzheimer's Disease

2002 • 209 citations

Wnt-3a overcomes β-amyloid toxicity in rat hippocampal neurons

2004 • 206 citations

Increased Expression of Cyclooxygenases and Peroxisome Proliferator-Activated Receptor-γ in Alzheimer's Disease Brains

1999 • 205 citations

Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex

2003 • 203 citations

Invited Review Cholinesterase inhibitors for Alzheimer’s disease therapy: from tacrine to future applications

1998 • 202 citations

Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway.

1999 • 189 citations

Peroxisome proliferator-activated receptor γ is expressed in hippocampal neurons and its activation prevents β-amyloid neurodegeneration: role of Wnt signaling

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Differential Mechanisms of LEF/TCF Family-Dependent Transcriptional Activation by β-Catenin and Plakoglobin

2000 • 181 citations

Abnormalities of neural circuitry in Alzheimer's disease

1998 • 179 citations

PPARγ signaling exacerbates mammary gland tumor development

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Mitotic phosphoepitopes precede paired helical filaments in Alzheimer’s disease

1998 • 177 citations

Wnt genes and vertebrate development

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Colocalization of cholinesterases with ? amyloid protein in aged and Alzheimer's brains

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Increased expression of Wnt-1 in schizophrenic brains

1999 • 160 citations

Protein kinase C inhibits amyloid β‐peptide neurotoxicity by acting on members of the Wnt pathway

2002 • 160 citations

Regulation of β-Catenin Levels and Localization by Overexpression of Plakoglobin and Inhibition of the Ubiquitin-Proteasome System

1997 • 157 citations

Presenilin 1 Facilitates the Constitutive Turnover of β-Catenin: Differential Activity of Alzheimer’s Disease–Linked PS1 Mutants in the β-Catenin–Signaling Pathway

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Axin: A Master Scaffold for Multiple Signaling Pathways

2004 • 151 citations

Fractionation and characterization of oligomeric, protofibrillar and fibrillar forms of β-amyloid peptide

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Plakoglobin (γ-catenin) has TCF/LEF family-dependent transcriptional activity in β-catenin-deficient cell line

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Wnt proteins promote neuronal differentiation in neural stem cell culture

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Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease

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Histochemically Reactive Zinc in Plaques of the Swedish Mutant β-Amyloid Precursor Protein Transgenic Mice

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Regulation of the Wnt signaling pathway by disabled-2 (Dab2)

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Molecular basis of lithium action: integration of lithium-responsive signaling and gene expression networks

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Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity

1995 • 130 citations

Alzheimer's disease: transiently developing dendritic changes in pyramidal cells of sector CA1 of the Ammon's horn

1997 • 130 citations

The Wnt pathway, cell-cycle activation and β-amyloid: novel therapeutic strategies in Alzheimer's disease?

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Increased soluble amyloid-β peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein

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GSK-3 and the neurodevelopmental hypothesis of schizophrenia

2002 • 125 citations

Acetylcholinesterase-Aβ Complexes Are More Toxic than Aβ Fibrils in Rat Hippocampus

2004 • 125 citations

Mitogen‐Activated Protein Kinase‐Dependent and Protein Kinase C‐Dependent Pathways Link the m1 Muscarinic Receptor to β‐Amyloid Precursor Protein Secretion

1998 • 122 citations

Bcl-2 Transcription from the Proximal P2 Promoter Is Activated in Neuronal Cells by the Brn-3a POU Family Transcription Factor

1998 • 122 citations

Dishevelled-1 Regulates Microtubule Stability

2000 • 120 citations

Dishevelled Regulates the Metabolism of Amyloid Precursor Protein via Protein Kinase C/Mitogen-Activated Protein Kinase and c-Jun Terminal Kinase

2001 • 119 citations

Muscarinic Receptor Activation Protects Cells from Apoptotic Effects of DNA Damage, Oxidative Stress, and Mitochondrial Inhibition

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Regulation of acetylcholine receptor clustering by the tumor suppressor APC

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Role of PPAR-γ Ligands In Neuroprotection against Glutamate-Induced Cytotoxicity in Retinal Ganglion Cells

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Presenilins Interact with Armadillo Proteins Including Neural‐Specific Plakophilin‐Related Protein and β‐Catenin

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Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease.

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Potentiation of Insulin Signaling in Tissues of Zucker Obese Rats After Acute and Long-Term Treatment With PPARγ Agonists

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A Monoclonal Antibody against Acetylcholinesterase Inhibits the Formation of Amyloid Fibrils Induced by the Enzyme

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From Molecular Structure to Alzheimer Therapy.

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Plakoglobin Regulates the Expression of the Anti-apoptotic Protein BCL-2

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GSK‐3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and β‐catenin stabilisation without elevation of glycogen synthase activity

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Long-term stabilizing effect of cholinesterase inhibitors in the therapy of Alzheimer’ disease

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Muscarinic m1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain

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Wnt-1 promotes neuronal differentiation and inhibits gliogenesis in P19 cells

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Copper reduction by copper binding proteins and its relation to neurodegenerative diseases.

2003 • 78 citations

Troglitazone inhibits both post-glutamate neurotoxicity and low-potassium-induced apoptosis in cerebellar granule neurons

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Acetylcholinesterase-amyloid-β-peptide interaction and Wnt signaling involvement in Aβ neurotoxicity

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M1 muscarinic receptor activation protects neurons from β-amyloid toxicity. A role for Wnt signaling pathway

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Networking with proline-directed protein kinases implicated in Tau phosphorylation

1995 • 60 citations

Distribution of m1 muscarinic acetylcholine receptors in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies—an immunohistochemical study

2001 • 56 citations

Regulation of WNT signaling molecules by retinoic acid during neuronal differentiation in NT2 cells: Threshold model of WNT action (Review)

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Cysteine 144 Is a Key Residue in the Copper Reduction by the β‐Amyloid Precursor Protein

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Overexpression of the mouse dishevelled‐1 protein inhibits GSK‐3β‐mediated phosphorylation of tau in transfected mammalian cells

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GSK3β Forms a Tetrameric Complex with Endogenous PS1‐CTF/NTF and β‐Catenin: Effects of the D257/D385A and FAD‐linked Mutations

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Implication of cyclin-dependent kinases and glycogen synthase kinase 3 in the phosphorylation of microtubule-associated protein 1B in developing neuronal cells

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Ectopic Expression of Axin Blocks Neuronal Differentiation of Embryonic Carcinoma P19 Cells

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Protein kinase C iota protects neural cells against apoptosis induced by amyloid β-peptide

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Role of protein kinase Cα in the regulated secretion of the amyloid precursor protein

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Presenilin 1 Regulates β-Catenin-mediated Transcription in a Glycogen Synthase Kinase-3-independent Fashion

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Fractionation and characterization of oligomeric, protofibrillar and fibrillar forms of β-amyloid peptide

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Competitive substrate inhibition in the histochemistry of cholinesterase activity in Alzheimer's disease

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