Potentiation of Insulin Signaling in Tissues of Zucker Obese Rats After Acute and Long-Term Treatment With PPARγ Agonists

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat.

1996 • 2,130 citations

The PPARs: From Orphan Receptors to Drug Discovery

2000 • 1,792 citations

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

2001 • 1,789 citations

PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.

1998 • 1,728 citations

Insulin resistance differentially affects the PI 3-kinase– and MAP kinase–mediated signaling in human muscle

2000 • 1,119 citations

PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation

2001 • 1,062 citations

Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes

1996 • 1,004 citations

Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.

1998 • 995 citations

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1998 • 969 citations

Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice

2001 • 950 citations

Prevention of fat-induced insulin resistance by salicylate

2001 • 713 citations

New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes

2001 • 695 citations

Treatment of insulin resistance with peroxisome proliferator–activated receptor γ agonists

2000 • 535 citations

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.

1995 • 524 citations

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2

2000 • 499 citations

Novel Peroxisome Proliferator-activated Receptor (PPAR) γ and PPARδ Ligands Produce Distinct Biological Effects

1999 • 412 citations

Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice.

1996 • 378 citations

Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones

2000 • 367 citations

Insulin Receptor Substrate-1 Phosphorylation and Phosphatidylinositol 3-Kinase Activity in Skeletal Muscle From NIDDM Subjects After In Vivo Insulin Stimulation

1997 • 347 citations

Troglitazone action is independent of adipose tissue.

1997 • 340 citations

Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.

1997 • 314 citations

Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha.

1996 • 313 citations

Thiazolidinediones in the treatment of insulin resistance and type II diabetes

1996 • 302 citations

Peroxisome proliferator activated receptors: transcriptional regulators of adipogenesis, lipid metabolism and more…

1995 • 293 citations

Insulin-Stimulated Akt Kinase Activity Is Reduced in Skeletal Muscle From NIDDM Subjects

1998 • 293 citations

The Insulin Receptor and Its Cellular Targets¹

2001 • 231 citations

Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus.

1993 • 220 citations

New approaches in the treatment of type 2 diabetes

2000 • 186 citations

Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice

2000 • 150 citations

Regulation of Gene Expression by Activation of the Peroxisome Proliferator-Activated Receptor γ with Rosiglitazone (BRL 49653) in Human Adipocytes

1999 • 131 citations

Role of Skeletal Muscle in Thiazolidinedione Insulin Sensitizer (PPARγ Agonist) Action

1998 • 131 citations

Thiazolidinediones (PPARγ agonists) but not PPAR α agonists increase IRS‐2 gene expression in 3T3‐L1 and human adipocytes¹

2001 • 127 citations

Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice.

1993 • 115 citations

Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats.

2000 • 108 citations

Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation

1997 • 97 citations

Exercise and thiazolidinedione therapy normalize insulin action in the obese Zucker fatty rat.

2000 • 92 citations

Membrane-targeted Phosphatidylinositol 3-Kinase Mimics Insulin Actions and Induces a State of Cellular Insulin Resistance

1999 • 91 citations

The Insulin Receptor and Its Cellular Targets

2001 • 88 citations

Persistent Activation of Phosphatidylinositol 3-Kinase Causes Insulin Resistance Due to Accelerated Insulin-Induced Insulin Receptor Substrate-1 Degradation in 3T3-L1 Adipocytes*

2000 • 66 citations

Potentiation of insulin stimulation of phosphatidylinositol 3-kinase by thiazolidinedione-derived antidiabetic agents in Chinese hamster ovary cells expressing human insulin receptors and L6 myotubes.

1994 • 57 citations

Acute troglitazone action in isolated perfused rat liver

1999 • 45 citations

Peroxisome proliferator-activated receptor (PPAR)γ agonists for diabetes

2001 • 37 citations

Hyperglycemia Impairs the Insulin Signaling Step between PI 3-Kinase and Akt/PKB Activations in ZDF Rat Liver

1999 • 36 citations

Chronic and acute effects of thiazolidinediones BM13.1258 and BM15.2054 on rat skeletal muscle glucose metabolism

1999 • 31 citations

Pioglitazone promotes insulin-induced activation of phosphoinositide 3-kinase in 3T3-L1 adipocytes by inhibiting a negative control mechanism

1994 • 22 citations

The oxazolidinedione CP-92,768-2 partially protects insulin receptor substrate-1 from dexamethasone down-regulation in 3T3-L1 adipocytes.

1995 • 15 citations

Actions of the novel antidiabetic agent englitazone in rat hepatocytes

1993 • 13 citations

Poglitazone promotes insulin-induced activation of phosphoinositide 3-kinase in 3T3-L1 adipocytes by inhibiting a negative control mechanism

1994 • 8 citations

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