Using inhibitors of metalloproteinases to treat arthritis. Easier said than done?

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1991 • 3,309 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Metalloproteinases and their inhibitors in matrix remodeling

1990 • 1,627 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Rheumatoid Arthritis

1990 • 1,565 citations

The matrix‐degrading metalloproteinases

1992 • 1,383 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

1990 • 1,272 citations

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

1992 • 1,252 citations

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

1992 • 1,200 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

The interaction of α2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism

1973 • 1,062 citations

Five intermediate complexes in transcription initiation by RNA polymerase II

1989 • 1,033 citations

Tissue Inhibitor of Metalloproteinase (TIMP-2)

1989 • 899 citations

Gene regulation by proteins acting nearby and at a distance

1986 • 886 citations

Interleukin‐6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides

1988 • 859 citations

Multiplicity generates diversity in the retinoic acid signalling pathways

1992 • 836 citations

Transforming growth factor-beta: recent progress and new challenges.

1992 • 781 citations

Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.

1993 • 738 citations

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.

1987 • 699 citations

A third human retinoic acid receptor, hRAR-gamma.

1989 • 686 citations

α-Macroglobulins: structure, shape, and mechanism of proteinase complex formation

1989 • 673 citations

Interleukin-1 Receptor Antagonist

1993 • 670 citations

Independent Regulation of Collagenase, 72-kDa Progelatinase, and Metalloendoproteinase Inhibitor Expression in Human Fibroblasts by Transforming Growth Factor-β

1989 • 649 citations

Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein.

1986 • 645 citations

Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage.

1989 • 604 citations

Activators and targets

1990 • 582 citations

Tetracyclines Inhibit Connective Tissue Breakdown: New Therapeutic Implications for an Old Family of Drugs

1991 • 522 citations

An A + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro.

1991 • 484 citations

TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence

1990 • 444 citations

Comparison of human stromelysin and collagenase by cloning and sequence analysis

1986 • 443 citations

A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts.

1993 • 383 citations

Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site.

1990 • 377 citations

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6.

1991 • 372 citations

Purification of rabbit bone inhibitor of collagenase

1981 • 352 citations

The Activation of Human Type IV Collagenase Proenzyme

1989 • 347 citations

Retinoids Selective for Retinoid X Receptor Response Pathways

1992 • 342 citations

The N-terminal domain of tissue inhibitor of metalloproteinases retains metalloproteinase inhibitory activity

1991 • 324 citations

Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo.

1992 • 282 citations

Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA)

1991 • 278 citations

A new inhibitor of metalloproteinases from chicken: ChIMP-3. A third member of the TIMP family.

1992 • 274 citations

Regulatory crosstalk at composite response elements

1991 • 261 citations

Detection of Stromelysin and Collagenase in Synovial Fluid From Patients with Rheumatoid Arthritis and Posttraumatic Knee Injury

1992 • 261 citations

Expression of Metalloproteinases and Metalloproteinase Inhibitor in Human Arthritic Synovium

1991 • 217 citations

In Situ Hybridization Studies of Stromelysin and Collagenase Messenger RNA Expression in Rheumatoid Synovium

1991 • 206 citations

Tetracyclines inhibit human synovial collagenase in vivo and in vitro.

1987 • 202 citations

Disulphide bond assignment in human tissue inhibitor of metalloproteinases (TIMP)

1990 • 176 citations

Regulation of c-myc mRNA Stability In Vitro by a Labile Destabilizer with an Essential Nucleic Acid Component

1989 • 172 citations

Tetracyclines suppress matrix metalloproteinase activity in adjuvant arthritis and in combination with flurbiprofen, ameliorate bone damage.

1992 • 164 citations

Human Fibroblast Collagenase-α-Macroglobulin Interactions

1989 • 164 citations

The measurement of collagenase, tissue inhibitor of metalloproteinases (timp), and collagenase—timp complex in synovial fluids from patients with osteoarthritis and rheumatoid arthritis

1993 • 163 citations

The AP-1 sequence is necessary but not sufficient for phorbol induction of collagenase in fibroblasts

1991 • 160 citations

Inhibition of purified collagenase from alkali-burned rabbit corneas.

1989 • 160 citations

AU RNA-binding factors differ in their binding specificities and affinities.

1992 • 157 citations

Antagonism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation.

1991 • 155 citations

lnterleukin-1 Stimulates andAll-Trans-Retinoic Acid Inhibits Collagenase Gene Expression through Its 5′ Activator Protein-1-Binding Site

1990 • 154 citations

Regulation of the expression of tissue inhibitor of metalloproteinases and collagenase by retinoids and glucocorticoids in human fibroblasts.

1987 • 146 citations

Selective regulation of metalloproteinase inhibitor (TIMP-1) by oncostatin M in fibroblasts in culture.

1993 • 146 citations

Refined 1·8 Å X-ray Crystal Structure of Astacin, a Zinc-endopeptidase from the Crayfish Astacus astacus L.

1993 • 138 citations

Interleukin-11, an inducible cytokine in human articular chondrocytes and synoviocytes, stimulates the production of the tissue inhibitor of metalloproteinases.

1993 • 133 citations

Interleukin-11, an inducible cytokine in human articular chondrocytes and synoviocytes, stimulates the production of the tissue inhibitor of metalloproteinases.

1993 • 124 citations

Post‐Transcriptional regulationa of collagenase and stromelysin gene expression by epidermal growth factor and dexamethasone in cultured human fibroblasts

1992 • 121 citations

The AP-1 site Is required for basal expression but is not necessary for TPA-response of the human stromelysin gene

1991 • 120 citations

A gene for rabbit synovial cell collagenase: member of a family of metalloproteinases that degrades the connective tissue matrix

1987 • 115 citations

IL-6/IFN-beta 2 in synovial effusions of patients with rheumatoid arthritis and other arthritides. Identification of several isoforms and studies of cellular sources.

1989 • 113 citations

A polyomavirus enhancer A-binding protein-3 site and Ets-2 protein have a major role in the 12-O-tetradecanoylphorbol-13-acetate response of the human stromelysin gene.

1993 • 112 citations

Interleukin 6 enhances the production of tissue inhibitor of metalloproteinases (TIMP) but not that of matrix metalloproteinases by human fibroblats

1990 • 109 citations

Biosynthesis and secretion of procollagenase by rabbit synovial fibroblasts. Inhibition of procollagenase secretion by monensin and evidence for glycosylation of procollagenase

1983 • 102 citations

Stromelysin and tissue inhibitor of metalloproteinases gene expression in rheumatoid arthritis synovium.

1992 • 97 citations

Doxycycline inhibits type XI collagenolytic activity of extracts from human osteoarthritic cartilage and of gelatinase.

1991 • 88 citations

Inhibition of tumor cell invasion by a highly conserved peptide sequence from the matrix metalloproteinase enzyme prosegment.

1992 • 86 citations

Regulation of collagenase gene expression by IL–1β requires transcriptional and post-transcriptional mechanisms

1994 • 85 citations

Transforming growth factor beta stimulates the production of the tissue inhibitor of metalloproteinases (TIMP) by human synovial and skin fibroblasts

1991 • 84 citations

Regulation of c-myc mRNA stability in vitro by a labile destabilizer with an essential nucleic acid component.

1989 • 82 citations

Minocycline treatment for rheumatoid arthritis: an open dose finding study.

1990 • 75 citations

Transforming growth factor-beta causes partial inhibition of interleukin 1 — Stimulated cartilage degradation in vitro

1989 • 68 citations

Regulation of human synovial fibroblast collagenase messenger RNA by interleukin‐1

1989 • 55 citations

An interleukin 1 beta point mutant demonstrates that jun/fos expression is not sufficient for fibroblast metalloproteinase expression.

1991 • 54 citations

Potent collagenase inhibitors prevent interleukin-1-induced cartilage degradation in vitro.

1991 • 51 citations

Regulation of metalloproteinase gene expression: implications for osteoarthritis.

1992 • 50 citations

Tetracycline in the treatment of rheumatoid arthritis. A double blind controlled study

1971 • 49 citations

A synthetic peptide metalloproteinase inhibitor, but not Timp, prevents the breakdown of proteoglycan within articular cartilagein vitro

1992 • 43 citations

Novel phorbol ester response region in the collagenase promoter binds Fos and Jun

1993 • 43 citations

Systemic administration of TIMP in the treatment of collagen-induced arthritis in mice

1989 • 42 citations

Dose-dependent suppression by the synthetic retinoid, 4-hydroxyphenyl retinamide, of streptococcal cell wall-induced arthritis in rats

1985 • 42 citations

Inhibition of Human Type IV Collagenase by a Highly Conserved Peptide Sequence Derived from Its Prosegment

1991 • 39 citations

Thiol-based inhibitors of mammalian collagenase. Substituted amide and peptide derivatives of the leucine analogue, 2-[(R,S)-mercaptomethyl]-4-methylpentanoic acid.

1990 • 39 citations

Regulation of Collagenase Gene Expression in Synovial Fibroblasts^a

1990 • 37 citations

Differential regulation of collagenase gene expression by retinoic acid receptors—α, β and γ

1992 • 36 citations

SYNOVIAL FLUIDS FROM INFECTED JOINTS CONTAIN ACTIVE METALLOPROTEINASES AND NO INHIBITORY ACTIVITY

1989 • 34 citations

Inhibition of Matrix Metalloproteinases: Therapeutic Potential

1994 • 33 citations

Inhibition of interleukin 1 beta induced rat and human cartilage degradation in vitro by the metalloproteinase inhibitor U27391.

1993 • 33 citations

The secretion of the tissue inhibitor of metalloproteinases (TIMP) by human synovial fibroblasts is modulated by all-trans-retinoic acid

1991 • 27 citations

Mode of action of razoxane: inhibition of basement membrane collagen-degradation by a malignant tumor enzyme.

1989 • 16 citations

Basement membrane collagen-degrading activity from a malignant tumor is inhibited by anthracycline antibiotics

1990 • 14 citations

Identification of tissue inhibitor of metalloproteinase-2 (TIMP-2)-progelatinase complex as the third metalloproteinase inhibitor peak in rheumatoid synovial fluid.

1993 • 13 citations