Regulation of Extracellular Matrix Remodeling following Transforming Growth Factor-β1/Epidermal Growth Factor-Stimulated Epithelial-Mesenchymal Transition in Human Premalignant Keratinocytes

Epithelial–mesenchymal transitions in tumour progression

2002 • 6,431 citations

Complex networks orchestrate epithelial–mesenchymal transitions

2006 • 3,818 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Epithelial-mesenchymal transition and its implications for fibrosis

2003 • 2,239 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

Molecular requirements for epithelial–mesenchymal transition during tumor progression

2005 • 1,799 citations

Epithelial–mesenchymal transitions in development and pathologies

2003 • 1,700 citations

The urokinase-type plasminogen activator system in cancer metastasis: A review

1997 • 1,561 citations

Regulation of matrix metalloproteinases: an overview.

2003 • 1,086 citations

TGF-β signaling: positive and negative effects on tumorigenesis

2002 • 830 citations

The two faces of transforming growth factor β in carcinogenesis

2003 • 740 citations

Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization

1998 • 683 citations

Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis

2003 • 679 citations

Leaving the neighborhood: molecular mechanisms involved during epithelial‐mesenchymal transition

2001 • 673 citations

Carcinoma Invasion and Metastasis: A Role for Epithelial-Mesenchymal Transition?

2005 • 647 citations

The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it

2005 • 628 citations

Genetic programs of epithelial cell plasticity directed by transforming growth factor-β

2001 • 520 citations

TGF-β: Regulation of extracellular matrix

1992 • 485 citations

Induction and regulation of epithelial–mesenchymal transitions

2000 • 434 citations

Transforming Growth Factor-β Signaling during Epithelial-Mesenchymal Transformation: Implications for Embryogenesis and Tumor Metastasis

2005 • 312 citations

The Plasminogen Activator Inhibitor PAI-1 Controls in Vivo Tumor Vascularization by Interaction with Proteases, Not Vitronectin

2001 • 311 citations

The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis

1998 • 308 citations

Molecular aspects of epithelial cell plasticity: implications for local tumor invasion and metastasis

2003 • 300 citations

Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes

1998 • 286 citations

Extracellular matrix regulates expression of the TGF-beta 1 gene.

1993 • 260 citations

Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF‐β1 involves MAPK, Smad and AP‐1 signalling pathways

2005 • 242 citations

Distinct mechanisms of TGF- 1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis

2005 • 220 citations

TGF-β-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cells

2004 • 214 citations

Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck.

2001 • 209 citations

Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion.

1998 • 189 citations

Matrix metalloproteinases and cellular fibrinolytic activity.

2002 • 163 citations

Differential expression of matrilysin‐1 (MMP‐7), 92 kD gelatinase (MMP‐9), and metalloelastase (MMP‐12) in oral verrucous and squamous cell cancer

2003 • 163 citations

Activities of the Matrix Metalloproteinase Stromelysin-2 (MMP-10) in Matrix Degradation and Keratinocyte Organization in Wounded Skin

2004 • 140 citations

Differential Regulation of Membrane Type 1-Matrix Metalloproteinase Activity by ERK 1/2- and p38 MAPK-modulated Tissue Inhibitor of Metalloproteinases 2 Expression Controls Transforming Growth Factor-β1-induced Pericellular Collagenolysis

2004 • 133 citations

Overexpression of epidermal growth factor receptor in human head and neck squamous carcinoma cell lines correlates with matrix metalloproteinase-9 expression andin vitro invasion

2000 • 127 citations

What is transforming growth factor-beta (TGF-β)?

2004 • 114 citations

Stromelysin-2 is Upregulated During Normal Wound Repair and is Induced by Cytokines

2000 • 109 citations

Regulation of the expression of stromelysin-2 by growth factors in keratinocytes: implications for normal and impaired wound healing

1996 • 102 citations

C-erbB receptors in squamous cell carcinomas of the head and neck: clinical significance and correlation with matrix metalloproteinases and vascular endothelial growth factors

2002 • 102 citations

Cell type-specific regulation of SL-1 and SL-2 genes. Induction of the SL-2 gene but not the SL-1 gene by human keratinocytes in response to cytokines and phorbolesters

1993 • 97 citations

Collagenase-1 (MMP-1), matrilysin-1 (MMP-7), and stromelysin-2 (MMP-10) are expressed by migrating enterocytes during intestinal wound healing

2004 • 93 citations

Plasminogen Is Present in the Basal Layer of the Epidermis

1983 • 91 citations

Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers

2001 • 89 citations

TGF-β1 stimulates production of gelatinase (MMP-9), collagenases (MMP-1, -13) and stromelysins (MMP-3, -10, -11) by human corneal epithelial cells

2004 • 85 citations

Collagenase 3 (matrix metalloproteinase 13) gene expression by HaCaT keratinocytes is enhanced by tumor necrosis factor alpha and transforming growth factor beta.

1997 • 83 citations

Transforming growth factor beta and fibroblast growth factor as promoters of tumor progression to malignancy.

1993 • 82 citations

Blocking transforming growth factor beta signaling in transgenic epidermis accelerates chemical carcinogenesis: a mechanism associated with increased angiogenesis.

1999 • 78 citations

Tumour-associated urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in normal and neoplastic tissues of patients with squamous cell cancer of the oral cavity – clinical relevance and prognostic value

2005 • 75 citations

Altered expression of the epidermal growth factor receptor and transforming growth factor‐α during multistage skin carcinogenesis in SENCAR mice

1994 • 71 citations

TGF-β1-induced PAI-1 expression is E box/USF-dependent and requires EGFR signaling

2006 • 64 citations

Transforming growth factor (TGF)-β in conjunction with H-ras activation promotes malignant progression of MCF10A breast epithelial cells

2004 • 64 citations

MMP expression profiling in recurred stage IB lung cancer

2003 • 60 citations

Induction of extracellular matrix gene expression in normal human keratinocytes by transforming growth factor β is altered by cellular differentiation

1991 • 60 citations

MMP-10 Is Overexpressed, Proteolytically Active, and a Potential Target for Therapeutic Intervention in Human Lung Carcinomas

2004 • 60 citations

Stromelysin-2 overexpression in human esophageal squamous cell carcinoma: potential clinical implications

2002 • 52 citations

Matrix Metalloproteinase-21 Is Expressed Epithelially During Development and in Cancer and Is Up-Regulated by Transforming Growth Factor-β1 in Keratinocytes

2003 • 50 citations

Enhancement of membrane-type 1-matrix metalloproteinase (MT1-MMP) production and sequential activation of progelatinase A on human squamous carcinoma cells co-cultured with human dermal fibroblasts

1999 • 44 citations

Transforming growth factor beta and the cell surface in tumor progression

1993 • 41 citations

Transforming Growth Factor-β Modulates Plasminogen Activator Activity and Plasminogen Activator Inhibitor Type-1 Expression in Human Keratinocytes In Vitro

1990 • 28 citations

Apposition-Dependent Induction of Plasminogen Activator Inhibitor Type 1 Expression: A Mechanism for Balancing Pericellular Proteolysis During Angiogenesis

1998 • 25 citations

Altered Epidermal Growth Factor Signal Transduction in Activated Ha-ras-Transformed Human Keratinocytes

1993 • 22 citations

Selective loss of PMA-stimulated expression of matrix metalloproteinase 1 in HaCaT keratinocytes is correlated with the inability to induce mitogen-activated protein family kinases

1999 • 21 citations

A Perspective on Regulation of Cell-Cell Adhesion and Epithelial-Mesenchymal Transition: Known and Novel

2005 • 20 citations