GENE THERAPY FOR MALIGNANT PLEURAL MESOTHELIOMA

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

1997 • 3,167 citations

Immunol. Cell Biol.

1995 • 2,564 citations

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

1992 • 1,530 citations

The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

1993 • 1,097 citations

Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

1991 • 994 citations

Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers.

1996 • 692 citations

Curability of Tumors Bearing Herpes Thymidine Kinase Genes Transfered by Retroviral Vectors

1990 • 514 citations

Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo.

1994 • 483 citations

Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression

1998 • 449 citations

In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.

1993 • 442 citations

Calretinin: A Novel Immunocytochemical Marker for Mesothelioma

1996 • 434 citations

Gene therapy: adenovirus vectors

1993 • 423 citations

Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase.

1994 • 420 citations

Regression of established macroscopic liver metastases after in situ transduction of a suicide gene.

1993 • 380 citations

Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy

1996 • 379 citations

Antiviral Activity and Mechanism of Action of Ganciclovir

1988 • 354 citations

Adenovirus-Mediated Herpes Simplex Virus Thymidine Kinase/Ganciclovir Gene Therapy in Patients with Localized Malignancy: Results of a Phase I Clinical Trial in Malignant Mesothelioma

1998 • 352 citations

Heat Shock Protein 70 Induced During Tumor Cell Killing Induces Th1 Cytokines and Targets Immature Dendritic Cell Precursors to Enhance Antigen Uptake

1999 • 332 citations

Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component.

1994 • 308 citations

Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy.

1996 • 278 citations

Drug sensitivity ("suicide") genes for selective cancer chemotherapy.

1994 • 277 citations

Complexes of Adenovirus with Polycationic Polymers and Cationic Lipids Increase the Efficiency of Gene Transfer in Vitro and in Vivo

1997 • 268 citations

Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro.

1996 • 260 citations

Simian virus-40 large-T antigen binds p53 in human mesotheliomas

1997 • 259 citations

Herpes simplex virus type 1 deletion variants 1714 and 1716 pinpoint neurovirulence-related sequences in Glasgow strain 17+ between immediate early gene 1 and the 'a' sequence

1991 • 256 citations

Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA.

1993 • 243 citations

SV40 induces mesotheliomas in hamsters.

1993 • 231 citations

Combination gene therapy for liver metastasis of colon carcinoma in vivo.

1995 • 222 citations

Impact of Preexisting and Induced Humoral and Cellular Immune Responses in an Adenovirus-Based Gene Therapy Phase I Clinical Trial for Localized Mesothelioma

1998 • 201 citations

Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression

1997 • 192 citations

Development and application of adenoviral vectors for gene therapy of cancer

1999 • 183 citations

Advances in adenoviral vectors: from genetic engineering to their biology

1997 • 179 citations

Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: an effective in vitro drug sensitization system.

1994 • 163 citations

Intrapleural treatment with recombinant gamma-interferon in early stage malignant pleural mesothelioma

1994 • 159 citations

Advances in the Treatment of Malignant Pleural Mesothelioma

1999 • 143 citations

Immune system in suicide-gene therapy

1997 • 142 citations

Natural History and Epidemiology of Malignant Mesothelioma

1993 • 133 citations

Adenovirus‐mediated gene therapy of experimental gliomas

1994 • 133 citations

The Calcium Binding Protein Calretinin is a Selective Marker for Malignant Pleural Mesotheliomas of the Epithelial Type

1996 • 130 citations

Activity of intrapleural recombinant gamma-interferon in malignant mesothelioma

1991 • 130 citations

Successful adenovirus-mediated gene transfer in an in vivo model of human malignant mesothelioma

1994 • 129 citations

Intrapleural administration of interleukin-2 for the treatment of patients with malignant pleural mesothelioma

1998 • 123 citations

Extrapleural pneumonectomy, chemotherapy, and radiotherapy in the treatment of diffuse malignant pleural mesothelioma

1991 • 123 citations

Re-expression of p16INK4a in mesothelioma cells results in cell cycle arrest, cell death, tumor suppression and tumor regression

1998 • 122 citations

Intrapleural cisplatin and cytarabine in the management of malignant pleural effusions: a Lung Cancer Study Group trial.

1991 • 122 citations

Current Approach to Malignant Mesothelioma of the Pleura

1995 • 113 citations

Use of a "replication-restricted" herpes virus to treat experimental human malignant mesothelioma.

1997 • 112 citations

Combination gene therapy for oral cancer in a murine model.

1996 • 111 citations

Treatment of Experimental Human Mesothelioma Using Adenovirus Transfer of the Herpes Simplex Thymidine Kinase Gene

1995 • 110 citations

Intrapleural administration of interleukin 2 in pleural mesothelioma: a phase I-II study

1995 • 106 citations

Induction of potent antitumor natural killer cell activity by herpes simplex virus-thymidine kinase and ganciclovir therapy in an orthotopic mouse model of prostate cancer.

1998 • 105 citations

The role of the bystander effect in suicide gene therapy

1997 • 105 citations

Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to treat in vivo models of human malignant mesothelioma and lung cancer.

1995 • 100 citations

Gene therapy approaches for inherited and acquired lung diseases.

1996 • 95 citations

Intrapleural Recombinant IL-2 in Passive Immunotherapy for Malignant Pleural Effusion

1993 • 92 citations

Transforming Growth Factor-Beta: Antisense RNA-Mediated Inhibition Affects Anchorage-Independent Growth, Tumorigenicity and Tumor-Infiltrating T-Cells in Malignant Mesothelioma

1994 • 91 citations

Gene Therapy for Peritoneal Dissemination of Pancreatic Cancer by Liposome-Mediated Transfer of Herpes Simplex Virus Thymidine Kinase Gene

1997 • 88 citations

Use of suicide genes in gene therapy

1994 • 87 citations

METHODS OF GENE DELIVERY

1998 • 86 citations

Intrapleural Natural Beta Interferon in the Treatment of Malignant Pleural Effusions

1988 • 83 citations

Cytokine Gene Therapy with Interleukin-2-Transduced Fibroblasts: Effects of IL-2 Dose on Anti-Tumor Immunity

1995 • 83 citations

Effect of Interferon-α_2aMalignant Mesothelioma

1993 • 82 citations

Superior cytotoxicity with ganciclovir compared with acyclovir and 1-beta-D-arabinofuranosylthymine in herpes simplex virus-thymidine kinase-expressing cells: a novel paradigm for cell killing.

1998 • 80 citations

The role of growth factors and cytokines in the tumorigenesis and immunobiology of malignant mesothelioma.

1995 • 79 citations

Manganese Superoxide Dismutase in Healthy Human Pleural Mesothelium and in Malignant Pleural Mesothelioma

1998 • 76 citations

Pleurectomy/Decortication and Adjuvant Therapy for Malignant Mesothelioma

1993 • 76 citations

Comparison of the effects of three different toxin genes and their levels of expression on cell growth and bystander effect in lung adenocarcinoma.

1996 • 67 citations

Cytokine Gene Therapy or Infusion as Treatment for Solid Human Cancer

1998 • 63 citations

Retinoids augment the bystander effect in vitro and in vivo in herpes simplex virus thymidine kinase/ganciclovir-mediated gene therapy

1997 • 62 citations

Treatment of Pleural Mesothelioma in an Immunocompetent Rat Model Utilizing Adenoviral Transfer of the Herpes Simplex Virus Thymidine Kinase Gene

1996 • 59 citations

Gene therapy of experimental malignant mesothelioma using adenovirus vectors encoding the HSVtk gene

1997 • 58 citations

Replicating vectors for gene therapy of cancer: risks, limitations and prospects

1994 • 56 citations

Mesothelioma and Radical Multimodality Therapy: Who Benefits?

1995 • 53 citations

Interleukin-12 Induces an Effective Antitumor Response in Malignant Mesothelioma

1998 • 44 citations

A Family of Bicistronic Vectors to Enhance Both Local and Systemic Antitumor Effects of HSVtk or Cytokine Expression in a Murine Melanoma Model

1997 • 43 citations

Cytokine Gene Therapy of Mesothelioma

1999 • 39 citations

Characterization of the antitumor immune response generated by treatment of murine tumors with recombinant adenoviruses expressing HSVtk, IL-2, IL-6 or B7-1

1997 • 38 citations

Altered CD3 chain and cytokine gene expression in tumor infiltrating T lymphocytes during the development of mesothelioma

1996 • 38 citations

Gene Transfer of Herpes Simplex Virus Type I Thymidine Kinase Gene as a Drug Sensitivity Gene into Human Lung Cancer Cell Lines Using Retroviral Vectors

1993 • 38 citations

Safety of Intrapleurally Administered Recombinant Adenovirus Carrying Herpes Simplex Thymidine Kinase DNA Followed by Ganciclovir Therapy in Nonhuman Primates

1996 • 37 citations

Clinical Protocol The Treatment of Malignant Mesothelioma with a Gene Modified Cancer Cell Line: A Phase I Study

1998 • 35 citations

The Mesothelial Cell and Mesothelioma

1995 • 34 citations

In vivo gene therapy of malignant tumours with heat shock protein-65 gene

1997 • 34 citations

Treatment of Advanced Mesothelioma with the Recombinant Adenovirus H5.010RSVTK: A Phase 1 Trial (BB-IND 6274)

1996 • 33 citations

The Treatment of Malignant Mesothelioma with a Gene Modified Cancer Cell Line: A Phase I Study. Louisiana State University Medical Center, New Orleans

1998 • 33 citations

Long-term survival of immunocompetent rats with intraperitoneal colon carcinoma tumors using herpes simplex thymidine kinase/ganciclovir and IL-2 treatments

1997 • 30 citations

Antitumor Activity with the HSV-tk-gene-modified Cell Line PA-1-STK in Malignant Mesothelioma

1998 • 30 citations

Multiple transduction as a means of preserving ganciclovir chemosensitivity in sarcoma cells carrying retrovirally transduced herpes thymidine kinase genes

1992 • 29 citations

Transfection of the gene for B7-1 but not B7-2 can induce immunity to murine malignant mesothelioma

1997 • 28 citations

GENE THERAPY FOR MALIGNANT GLIOMAS

1998 • 26 citations

P450 Cytochromes and Hormonal Regulation: An Overview

1996 • 25 citations

Gene therapy study of cytokine-transfected xenogeneic cells (Vero-interleukin-2) in patients with metastatic solid tumors

1999 • 25 citations

Gene therapy for malignant mesothelioma: a novel approach for an incurable cancer with increased incidence in Louisiana.

1998 • 24 citations

The induction of immune responses to murine malignant mesothelioma by IL‐2 gene transfer

1997 • 22 citations

Interleukin-2 and Lymphokine-Activated Killer-Cells in Malignant Mesothelioma

1993 • 21 citations

Suicidal gene therapy for pleural metastasis of lung cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene

1999 • 20 citations

Trials in Malignant Mesothelioma

1994 • 19 citations

The Mesothelial Cell and Mesothelioma

1994 • 17 citations

Cancer escape from immune surveillance: How can it be overcome by gene transfer?

1994 • 15 citations

In Vivo Transfer of Bacterial Marker Genes Results in Differing Levels of Gene Expression and Tumor Progression in Immunocompetent and Immunodeficient Mice

1999 • 12 citations

926 Intralesional vaccinia virus-interleukin 2 (VV-IL2) gene therapy in malignant mesothelioma (MM)

1997 • 5 citations

Gene therapy or therapy with intratumoral cytokines by infusion in mesothelioma patients

1997 • 4 citations

Deleted Work

1955 • 0 citations