A Family of Bicistronic Vectors to Enhance Both Local and Systemic Antitumor Effects of HSVtk or Cytokine Expression in a Murine Melanoma Model

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells.

1993 • 1,395 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1990 • 926 citations

Treatment of Established Renal Cancer by Tumor Cells Engineered to Secrete Interleukin-4

1991 • 733 citations

High-titer packaging cells producing recombinant retroviruses resistant to human serum

1995 • 672 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 637 citations

Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity.

1990 • 628 citations

Cloning and expression of murine immune interferon cDNA.

1983 • 455 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 416 citations

Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1.

1981 • 388 citations

Regression of established macroscopic liver metastases after in situ transduction of a suicide gene.

1993 • 380 citations

The Encephalomyocarditis Virus Internal Ribosome Entry Site Allows Efficient Coexpression of Two Genes from a Recombinant Provirus in Cultured Cells and in Embryos

1991 • 333 citations

Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component.

1994 • 308 citations

Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors.

1994 • 302 citations

Is cancer dangerous to the immune system?

1996 • 296 citations

Drug sensitivity ("suicide") genes for selective cancer chemotherapy.

1994 • 277 citations

Experimental and Clinical Studies of Cytokine Gene-Modified Tumor Cells

1994 • 259 citations

Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA.

1993 • 243 citations

The encephalomyocarditis virus internal ribosome entry site allows efficient coexpression of two genes from a recombinant provirus in cultured cells and in embryos.

1991 • 235 citations

Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor.

1994 • 224 citations

Combination gene therapy for liver metastasis of colon carcinoma in vivo.

1995 • 222 citations

Safety Issues Related to Retroviral-Mediated Gene Transfer in Humans

1991 • 207 citations

Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression

1997 • 192 citations

Local cytokine availability elicits tumor rejection and systemic immunity through granulocyte-T-lymphocyte cross-talk.

1992 • 187 citations

Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and gamma-interferon gene or admixed with conventional adjuvants.

1994 • 167 citations

Controlled release, biodegradable cytokine depots: a new approach in cancer vaccine design.

1993 • 164 citations

Occurrence of enzymes involved in biosynthesis of indole-3-acetic acid from indole-3-acetonitrile in plant-associated bacteria, Agrobacterium and Rhizobium.

1995 • 128 citations

Cancer vaccines: the interleukin 2 dosage effect.

1995 • 127 citations

Antitumor effects of granulocyte-macrophage colony-stimulating factor production by melanoma cells.

1996 • 112 citations

Combination gene therapy for oral cancer in a murine model.

1996 • 111 citations

Anti‐metastatic vaccination of tumor‐bearing mice with il‐2‐gene‐inserted tumor cells

1993 • 99 citations

Priming of tumor-specific T cells in the draining lymph nodes after immunization with interleukin 2-secreting tumor cells: three consecutive stages may be required for successful tumor vaccination.

1995 • 94 citations

Two competing influences that may explain concomitant tumor resistance.

1993 • 88 citations

In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumors

1994 • 87 citations

Protective and curative potential of vaccination with interleukin-2-gene-transfected cells from a spontaneous mouse mammary adenocarcinoma.

1993 • 83 citations

Gene therapy of metastatic cancer by in vivo retroviral gene targeting

1995 • 76 citations

Tissue-Specific Gene Expression from Mo-MLV Retroviral Vectors with Hybrid LTRs Containing the Murine Tyrosinase Enhancer/Promoter

1995 • 61 citations

A comparison of the properties of different retroviral vectors containing the murine tyrosinase promoter to achieve transcriptionally targeted expression of the HSVtk or IL-2 genes.

1994 • 58 citations

Vectors for cancer gene therapy

1996 • 36 citations

Cure of Mice with Established Metastatic Friend Leukemia Cell Tumors by a Combined Therapy with Tumor Cells Expressing Both Interferon-α1 and Herpes Simplex Thymidine Kinase Followed by Ganciclovir

1996 • 35 citations

Targeting of cytokine gene expression to malignant melanoma cells using tissue specific promoter sequences

1994 • 31 citations

Highly efficient action of autocrine mouse interferon‐γ expressed via a retroviral vector

1988 • 23 citations

Suppression of Single and Double Nonsense Mutations Introduced into the Diphtheria Toxin A-Chain Gene: A Potential Binary System for Toxin Gene Therapy

1995 • 19 citations

Immunotherapy III: Combinatorial molecular immunotherapy-a synthesis and suggestions

1996 • 18 citations