Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Programmed cell death involved in the schizolysigenous formation of the secretory cavity in Citrus sinensis L. (Osbeck)

2010 • 1,629 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

1993 • 1,097 citations

Neonatal Tolerance Revisited: Turning on Newborn T Cells with Dendritic Cells

1996 • 770 citations

Apoptosis (the 1992 Frank Rose Memorial Lecture)

1993 • 447 citations

Regression of established macroscopic liver metastases after in situ transduction of a suicide gene.

1993 • 380 citations

Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component.

1994 • 308 citations

Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors.

1994 • 302 citations

Drug sensitivity ("suicide") genes for selective cancer chemotherapy.

1994 • 277 citations

Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA.

1993 • 243 citations

The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro.

1995 • 209 citations

Apoptosis in interleukin-3-dependent haemopoietic cells

1992 • 207 citations

5-Fluorocytosine-induced eradication of murine adenocarcinomas engineered to express the cytosine deaminase suicide gene requires host immune competence and leaves an efficient memory.

1995 • 109 citations

Human melanocytes and melanoma cells constitutively express the Bcl-2 proto-oncogene in situ and in cell culture.

1995 • 97 citations

Priming of tumor-specific T cells in the draining lymph nodes after immunization with interleukin 2-secreting tumor cells: three consecutive stages may be required for successful tumor vaccination.

1995 • 94 citations

Long-Term Secretion of Therapeutic Proteins from Genetically Modified Skeletal Muscles

1996 • 76 citations

A comparison of the properties of different retroviral vectors containing the murine tyrosinase promoter to achieve transcriptionally targeted expression of the HSVtk or IL-2 genes.

1994 • 58 citations

Gene therapy of hepatoma: bystander effects and non-apoptotic cell death induced by thymidine kinase and ganciclovir

1995 • 52 citations

New therapeutic approaches based on gene transfer techniques

1996 • 6 citations