Cytokine Gene Therapy of Mesothelioma

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Antitumor and antimetastatic activity of interleukin 12 against murine tumors.

1993 • 1,206 citations

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

1991 • 976 citations

Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production.

1994 • 796 citations

Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

1987 • 722 citations

Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo.

1995 • 710 citations

Biochemical characterization of a gamma interferon-inducible cytokine (IP-10).

1987 • 643 citations

Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice

1995 • 491 citations

Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10

1996 • 480 citations

The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation.

1995 • 456 citations

Preferential effect of γ interferon on the synthesis of HLA antigens and their mRNAs in human cells

1982 • 386 citations

Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or -independent mechanisms.

1994 • 372 citations

Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo.

1994 • 335 citations

Clinical Trials: IL-12 Deaths: Explanation and a Puzzle

1995 • 333 citations

Regulation of human cytolytic lymphocyte responses by interleukin-12

1992 • 331 citations

Fibroblasts as Efficient Antigen-Presenting Cells in Lymphoid Organs

1995 • 308 citations

Interferon γ-Inducible Protein-10 (IP-10), a Member of the C-X-C Chemokine Family, Is an Inhibitor of Angiogenesis

1995 • 293 citations

Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector.

1995 • 277 citations

Nitric oxide is an important mediator for tumoricidal activity in vivo.

1994 • 249 citations

Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumors.

1996 • 248 citations

Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.

1996 • 231 citations

Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts.

1995 • 206 citations

Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-γ production by anti-tumor T cells

1995 • 202 citations

Direct Intratumoral Injection of an Adenovirus Expressing Interleukin-12 Induces Regression and Long-Lasting Immunity That Is Associated with Highly Localized Expression of Interleukin-12

1996 • 193 citations

IL-12 induces T helper 1-directed antitumor response.

1997 • 189 citations

Establishment of a murine model of malignant mesothelioma

1992 • 184 citations

Amount of interleukin 12 available at the tumor site is critical for tumor regression.

1996 • 177 citations

Tumor Antigens are Constitutively Presented in the Draining Lymph Nodes

1999 • 170 citations

A mouse mutant p53 product recognized by CD4+ and CD8+ T cells.

1994 • 168 citations

Cooperation of Natural Killer Cell Stimulatory Factor/Interleukin-12 with Other Stimuli in the Induction of Cytokines and Cytotoxic Cell-Associated Molecules in Human T and NK Cells

1994 • 162 citations

Administration of recombinant interleukin 12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes.

1995 • 138 citations

IL-12 is an effective adjuvant to recombinant vaccinia virus-based tumor vaccines: enhancement by simultaneous B7-1 expression.

1996 • 129 citations

CD4 T cells inhibit in vivo the CD8‐mediated immune response against murine colon carcinoma cells transduced with interleukin‐12 genes

1995 • 125 citations

B7-1 and interleukin 12 synergistically induce effective antitumor immunity.

1995 • 118 citations

Interleukin-12 Promotes the Proliferation and Cytolytic Maturation of Immune Effectors

1993 • 101 citations

Establishment and characterization of five human malignant mesothelioma cell lines derived from pleural effusions

1991 • 99 citations

Effect of Interferon-α_2aMalignant Mesothelioma

1993 • 82 citations

High cytokine production and effective antitumor activity of a recombinant vaccinia virus encoding murine interleukin 12.

1995 • 76 citations

Historical perspectives in occupational medicine. Wittenoom, western Australia: A modern industrial disaster

1992 • 65 citations

Patho- and immunobiology of malignant mesothelioma: characterisation of tumour infiltrating leucocytes and cytokine production in a murine model

1994 • 54 citations

Interleukin-12 Induces an Effective Antitumor Response in Malignant Mesothelioma

1998 • 44 citations

Projection of asbestos related diseases in the United States, 1985-2009. I. Cancer.

1988 • 41 citations

Altered CD3 chain and cytokine gene expression in tumor infiltrating T lymphocytes during the development of mesothelioma

1996 • 38 citations

Bone Marrow‐Derived Cells Present MHC Class I‐Restricted Tumour Antigens in Priming of Antitumour Immune Responses

2007 • 34 citations

Transfection of the gene for B7-1 but not B7-2 can induce immunity to murine malignant mesothelioma

1997 • 28 citations

Conventional Treatment and its Effect on Survival of Malignant Pleural Mesothelioma in Western Australia

1982 • 26 citations

Induction and maintenance of T-cell response to a nonimmunogenic murine mesothelioma cell line requires expression of B7-1 and the capacity to upregulate class II major histocompatibility complex expression.

1996 • 17 citations

Projection of Asbestos-related Diseases in the United States, 1985-2009

1989 • 16 citations