Scaffold-attached regions (SAR elements) mediate transcriptional effects due to butyrate

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

1990 • 1,835 citations

Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

1986 • 922 citations

Effects of sodium butyrate, a new pharmacological agent, on cells in culture

1981 • 808 citations

A position-effect assay for boundaries of higher order chromosomal domains

1991 • 616 citations

A nuclear DNA attachment element mediates elevated and position-independent gene activity

1989 • 597 citations

A glimpse at chromosomal order

1987 • 423 citations

Biological Significance of Unwinding Capability of Nuclear Matrix-Associating DNAs

1992 • 407 citations

Histone acetylation reduces nucleosome core particle linking number change

1989 • 394 citations

The chicken lysozyme 5' matrix attachment region increases transcription from a heterologous promoter in heterologous cells and dampens position effects on the expression of transfected genes.

1990 • 276 citations

The size of chromatin loops in HeLa cells.

1990 • 246 citations

The enhancer of the immunoglobulin heavy chain locus is flanked by presumptive chromosomal loop anchorage elements.

1987 • 229 citations

Manifold effects of sodium butyrate on nuclear function. Selective and reversible inhibition of phosphorylation of histones H1 and H2A and impaired methylation of lysine and arginine residues in nuclear protein fractions.

1981 • 179 citations

Scaffold-attached regions from the human interferon .beta. domain can be used to enhance the stable expression of genes under the control of various promoters

1991 • 177 citations

Chromatin domain surrounding the human interferon-.beta. gene as defined by scaffold-attached regions

1988 • 169 citations

Production of analytical quantities of recombinant proteins in Chinese hamster ovary cells using sodium butyrate to elevate gene expression

1991 • 154 citations

Torsional stress stabilizes extended base unpairing in suppressor sites flanking immunoglobulin heavy chain enhancer

1990 • 135 citations

Nucleosome linking number change controlled by acetylation of histones H3 and H4.

1990 • 132 citations

Hierarchical binding of DNA fragments derived from scaffold-attached regions: correlation of properties in vitro and function in vivo

1990 • 131 citations

Histone hyperacetylation can induce unfolding of the nucleosome core particle

1990 • 118 citations

A developmental-specific factor binds to suppressor sites flanking the immunoglobulin heavy-chain enhancer.

1989 • 116 citations

Histone deacetylase is a component of the internal nuclear matrix.

1991 • 110 citations

A + T-rich linkers define functional domains in eukaryotic DNA

1982 • 104 citations

Poising chromatin for transcription

1987 • 103 citations

Nucleosomal Particles Open as the Histone Core Becomes Hyperacetylated

1983 • 93 citations

Mapping of Structural and Transcription-Related Matrix Attachment Sites in the α-Globin Gene Domain of Avian Erythroblasts and Erythrocytes

1990 • 76 citations

Modulation of the Nucleosome Structure by Histone Acetylation

1980 • 76 citations

Negative supercoiling of DNA facilitates an interaction between transcription factor IID and the fibroin gene promoter.

1991 • 72 citations

Inducibility of human β-interferon gene in mouse L-cell clones

1982 • 66 citations

DNA bending and nucleosome positioning

1987 • 65 citations

Mutational analysis of sodium butyrate inducible elements in the human immunodeficiency virus type I long yerminal repeat

1989 • 64 citations

Structural changes in nucleosomes during transcription: strip, split or flip?

1991 • 64 citations

Nucleosome fractionation by mercury affinity chromatography. Contrasting distribution of transcriptionally active DNA sequences and acetylated histones in nucleosome fractions of wild-type yeast cells and cells expressing a histone H3 gene altered to encode a cysteine 110 residue.

1991 • 58 citations

Factors affecting nucleosome structure in transcriptionally active chromatin

1990 • 51 citations

The nuclear scaffold exhibits DNA-binding sites selective for supercoiled DNA.

1988 • 45 citations

Interferon production by human lymphoblastoid cells is stimulated by inducers of friend cell differentiation

1979 • 44 citations

Systematic punctuation of eukaryotic DNA by A+T-rich sequences.

1981 • 42 citations

Cooperative interaction of multiple DNA elements in the human interferon-beta promoter

1987 • 39 citations

Expression of Interferon‐α and Interferon‐β Genes in Human Lymphoblastoid (Namalwa) Cells

1983 • 35 citations

Enhancement of interferon mRNA levels in butyric acid‐treated namalwa cells

1980 • 29 citations

Chromatin structure and induction-dependent conformational changes of human interferon-beta genes in a mouse host cell

1986 • 28 citations

Enhanced Production of Interferon from Human Lymphoblastoid (Namalwa) Cells Pre-treated with Sodium Butyrate

1980 • 22 citations

The Extent of Histone Acetylation Induced by Butyrate and the Turnover of Acetyl Groups Depends on the Nature of the Cell Line

1981 • 22 citations

Sodium butyrate inhibits c‐myc and stimulates c‐fos expression in all the steps of the cell‐cycle in hepatoma tissue cultured cells

1990 • 20 citations

Nucleosomal corformations induced by the small HMG proteins or by histone hyperacetylation are distinct

1984 • 20 citations

Influence of histone hyperacetylation on nucleosomal particles as visualized by electron microscopy

1984 • 14 citations

The functional organizaton of chromosomes and the nucleos

1990 • 11 citations

DNA supercoiling and eukaryotic transcription. Cause and effect.

1990 • 8 citations

Links Between Effects of Butyrate on Histone Hyperacetylation and Regulation of Interferon Synthesis in Namalva and FS-4 Cell Lines

1982 • 7 citations