Nuclear receptors: coactivators, corepressors and chromatin remodeling in the control of transcription

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

1997 • 2,100 citations

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1995 • 2,059 citations

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

1998 • 1,902 citations

AIB1, a Steroid Receptor Coactivator Amplified in Breast and Ovarian Cancer

1997 • 1,655 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300

1997 • 1,472 citations

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1996 • 1,457 citations

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

1997 • 1,300 citations

Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase

1997 • 1,251 citations

Steroid receptor coactivator-1 is a histone acetyltransferase

1997 • 1,245 citations

A positive role for histone acetylation in transcription factor access to nucleosomal DNA

1993 • 1,116 citations

TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors.

1996 • 1,095 citations

Chromatin Structure and Function

1979 • 1,050 citations

brahma: A regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2SWI2

1992 • 951 citations

Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression

1997 • 945 citations

Structure and specificity of nuclear receptor–coactivator interactions

1998 • 922 citations

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

1997 • 856 citations

Stimulation of GAL4 Derivative Binding to Nucleosomal DNA by the Yeast SWI/SNF Complex

1994 • 853 citations

Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.

1996 • 830 citations

Differential Recognition of Target Genes by Nuclear Receptor Monomers, Dimers, and Heterodimers*

1994 • 789 citations

The nucleosomal core histone octamer at 3.1 A resolution: a tripartite protein assembly and a left-handed superhelix.

1991 • 720 citations

Rapid and Phosphoinositol-Dependent Binding of the SWI/SNF-like BAF Complex to Chromatin after T Lymphocyte Receptor Signaling

1998 • 719 citations

Diversity and specialization of mammalian SWI/SNF complexes.

1996 • 703 citations

GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors.

1996 • 702 citations

Replication-Dependent Marking of DNA by PCNA Facilitates CAF-1-Coupled Inheritance of Chromatin

1999 • 674 citations

Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes

1998 • 667 citations

ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor

1994 • 662 citations

Coactivator and Corepressor Regulation of the Agonist/Antagonist Activity of the Mixed Antiestrogen, 4-Hydroxytamoxifen

1997 • 640 citations

Transcription Factor-Specific Requirements for Coactivators and Their Acetyltransferase Functions

1998 • 639 citations

The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.

1995 • 627 citations

Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation

1998 • 609 citations

Co-activators and co-repressors in the integration of transcriptional responses

1998 • 606 citations

A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor.

1993 • 598 citations

Folding of the DNA double helix in chromatin-like structures from simian virus 40.

1975 • 597 citations

Sequence-specific positioning of nucleosomes over the steroid-inducible MMTV promoter.

1987 • 597 citations

Facilitated binding of TATA-binding protein to nucleosomal DNA

1994 • 593 citations

Acetylation of general transcription factors by histone acetyltransferases

1997 • 588 citations

RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2

1997 • 585 citations

Hormone-Dependent Coactivator Binding to a Hydrophobic Cleft on Nuclear Receptors

1998 • 580 citations

Steroid hormone receptors compete for factors that mediate their enhancer function

1989 • 580 citations

Polarity-specific activities of retinoic acid receptors determined by a co-repressor

1995 • 569 citations

Disruption of Higher-Order Folding by Core Histone Acetylation Dramatically Enhances Transcription of Nucleosomal Arrays by RNA Polymerase III

1998 • 568 citations

GENES AFFECTING THE REGULATION OF SUC2 GENE EXPRESSION BY GLUCOSE REPRESSION IN SACCHAROMYCES CEREVISIAE

1984 • 567 citations

Repression by Ume6 Involves Recruitment of a Complex Containing Sin3 Corepressor and Rpd3 Histone Deacetylase to Target Promoters

1997 • 546 citations

Evidence that SNF2/SWI2 and SNF5 activate transcription in yeast by altering chromatin structure.

1992 • 535 citations

A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors.

1996 • 532 citations

Assembly and propagation of repressed and derepressed chromosomal states

1985 • 518 citations

Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex

1998 • 507 citations

Modular structure of a chicken lysozyme silencer: Involvement of an unusual thyroid hormone receptor binding site

1990 • 487 citations

Roles of SWI1, SWI2, and SWI3 Proteins for Transcriptional Enhancement by Steroid Receptors

1992 • 477 citations

Histone acetylation: chromatin in action

1997 • 475 citations

The Partial Agonist Activity of Antagonist-Occupied Steroid Receptors Is Controlled by a Novel Hinge Domain-Binding Coactivator L7/SPA and the Corepressors N-CoR or SMRT

1997 • 468 citations

Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4.

1996 • 460 citations

Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila.

1988 • 460 citations

Five SWI genes are required for expression of the HO gene in yeast

1984 • 450 citations

Reversible and persistent changes in chromatin structure accompany activation of a glucocorticoid-dependent enhancer element

1984 • 449 citations

Nucleosome positioning modulates accessibility of regulatory proteins to the mouse mammary tumor virus promoter

1990 • 440 citations

Chromatin Structure and Function

1999 • 438 citations

Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.

1995 • 431 citations

Studies of the DNA binding properties of histone H4 amino terminus. Thermal denaturation studies reveal that acetylation markedly reduces the binding constant of the H4 “tail” to DNA.

1993 • 423 citations

CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription.

1996 • 414 citations

Transcription Factor Loading on the MMTV Promoter: A Bimodal Mechanism for Promoter Activation

1992 • 411 citations

Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1.

1996 • 410 citations

Five SWI/SNF gene products are components of a large multisubunit complex required for transcriptional enhancement.

1994 • 410 citations

p300 is a component of an estrogen receptor coactivator complex.

1996 • 399 citations

Histone acetylation reduces nucleosome core particle linking number change

1989 • 394 citations

The histone acetylase PCAF is a nuclear receptor coactivator

1998 • 389 citations

A correlation of thyroid hormone receptor gene expression with amphibian metamorphosis.

1990 • 388 citations

TRAM-1, A Novel 160-kDa Thyroid Hormone Receptor Activator Molecule, Exhibits Distinct Properties from Steroid Receptor Coactivator-1

1997 • 380 citations

Transcription factor access is mediated by accurately positioned nucleosomes on the mouse mammary tumor virus promoter.

1991 • 372 citations

Targeting Chromatin Disruption: Transcription Regulators that Acetylate Histones

1996 • 369 citations

RNA Polymerase II Holoenzyme Contains SWI/SNF Regulators Involved in Chromatin Remodeling

1996 • 364 citations

Two human homologues ofSaccharomyces cerevisiae SWI2/SNF2andDrosophila brahmaare transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor

1994 • 338 citations

Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators

1998 • 337 citations

Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone.

1993 • 328 citations

Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase

1998 • 318 citations

Specific glucocorticoid receptor binding to DNA reconstituted in a nucleosome.

1988 • 316 citations

Hormone induces binding of receptors and transcription factors to a rearranged nucleosome on the MMTV promoter in vivo.

1995 • 313 citations

Mobile nucleosomes--a general behavior.

1992 • 309 citations

A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor.

1992 • 302 citations

The contribution of the N- and C-terminal regions of steroid receptors to activation of transcription is both receptor and cell-specific

1989 • 299 citations

The Drosophila trithorax group proteins BRM, ASH1 and ASH2 are subunits of distinct protein complexes

1998 • 287 citations

Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repression.

1993 • 262 citations

The t4 Activation Domain of the Thyroid Hormone Receptor Is Required for Release of a Putative Corepressor(s) Necessary for Transcriptional Silencing

1995 • 250 citations

Amino acid substitutions in the structured domains of histones H3 and H4 partially relieve the requirement of the yeast SWI/SNF complex for transcription.

1995 • 245 citations

Structure and Function of the Core Histone N-Termini: More Than Meets the Eye

1998 • 241 citations

An Asymmetric Model for the Nucleosome: A Binding Site for Linker Histones Inside the DNA Gyres

1996 • 233 citations

A role for nucleosome assembly in both silencing and activation of the Xenopus TR beta A gene by the thyroid hormone receptor.

1995 • 225 citations

The transcriptionally-active MMTV promoter is depleted of histone H1

1992 • 222 citations

A nucleosome-dependent static loop potentiates estrogen-regulated transcription from the Xenopus vitellogenin B1 promoter in vitro.

1993 • 219 citations

SAP30, a Component of the mSin3 Corepressor Complex Involved in N-CoR-Mediated Repression by Specific Transcription Factors

1998 • 212 citations

Activator-dependent regulation of transcriptional pausing on nucleosomal templates.

1996 • 205 citations

Minichromosome assembly of non-integrated plasmid DNA transfected into mammalian cells

1985 • 196 citations

Genetic Analysis of brahma: The Drosophila Homolog of the Yeast Chromatin Remodeling Factor SWI2/SNF2

1998 • 188 citations

The earliest changes in gene expression in tadpole intestine induced by thyroid hormone.

1993 • 185 citations

Transcriptional repression of Xenopus TR beta gene is mediated by a thyroid hormone response element located near the start site.

1994 • 183 citations

Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers

1994 • 174 citations

Unique forms of human and mouse nuclear receptor corepressor SMRT

1999 • 174 citations

A positive role for nucleosome mobility in the transcriptional activity of chromatin templates: restriction by linker histones.

1995 • 172 citations

Coactivator and Corepressor Regulation of the Agonist/Antagonist Activity of the Mixed Antiestrogen, 4-Hydroxytamoxifen

1997 • 167 citations

Distinct steady–state nuclear receptor coregulator complexes exist in vivo

1998 • 165 citations

Formation and stability of higher order chromatin structures. Contributions of the histone octamer.

1994 • 163 citations

Replication-coupled chromatin assembly is required for the repression of basal transcription in vivo.

1993 • 163 citations

Yeast alpha 2 repressor positions nucleosomes in TRP1/ARS1 chromatin.

1990 • 161 citations

Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase

1998 • 161 citations

Glucocorticoid Receptor-Glucocorticoid Response Element Binding Stimulates Nucleosome Disruption by the SWI/SNF Complex

1997 • 159 citations

Alpha-helix in the carboxy-terminal domains of histones H1 and H5.

1988 • 159 citations

Coordinated Regulation of and Transcriptional Activation by Xenopus Thyroid Hormone and Retinoid X Receptors

1995 • 157 citations

Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor

1995 • 154 citations

Determinants of chromatin disruption and transcriptional regulation instigated by the thyroid hormone receptor: hormone-regulated chromatin disruption is not sufficient for transcriptional activation

1997 • 149 citations

Prolonged glucocorticoid exposure dephosphorylates histone H1 and inactivates the MMTV promoter

1998 • 144 citations

A role for helix 3of the TRbeta ligand-binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormone

1998 • 142 citations

Histone acetylation facilitates RNA polymerase II transcription of the Drosophila hsp26 gene in chromatin

1998 • 139 citations

What do linker histones do in chromatin?

1997 • 139 citations

Glucocorticoid receptor-dependent disruption of a specific nucleosome on the mouse mammary tumor virus promoter is prevented by sodium butyrate.

1990 • 135 citations

Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex

1997 • 134 citations

RNA Polymerase II Holoenzyme Recruitment Is Sufficient to Remodel Chromatin at the Yeast PHO5 Promoter

1997 • 133 citations

Translational positioning of a nucleosomal glucocorticoid response element modulates glucocorticoid receptor affinity.

1993 • 133 citations

Nucleosome Structural Changes Due to Acetylation

1994 • 133 citations

Nucleosome-mediated disruption of transcription factor-chromatin initiation complexes at the mouse mammary tumor virus long terminal repeat in vivo.

1994 • 128 citations

Transcriptional Repression by the SMRT-mSin3 Corepressor: Multiple Interactions, Multiple Mechanisms, and a Potential Role for TFIIB

1998 • 127 citations

The Partial Agonist Activity of Antagonist-Occupied Steroid Receptors Is Controlled by a Novel Hinge Domain-Binding Coactivator L7/SPA and the Corepressors N-CoR or SMRT

1997 • 126 citations

The identification of distinct populations of acetylated histone.

1980 • 122 citations

A natural transactivation mutation in the thyroid hormone β receptor: Impaired interaction with putative transcriptional mediators

1997 • 117 citations

Nucleosomes inhibit both transcriptional initiation and elongation by RNA polymerase III in vitro.

1989 • 115 citations

Histone-DNA interactions and their modulation by phosphorylation of -Ser-Pro-X-Lys/Arg- motifs.

1991 • 113 citations

Assembly of DNA and protein during replication in HeLa cells

1975 • 100 citations

Analysis of structure and expression of the Xenopus thyroid hormone receptor-beta gene to explain its autoinduction.

1995 • 99 citations

Moderate increase in histone acetylation activates the mouse mammary tumor virus promoter and remodels its nucleosome structure.

1996 • 97 citations

Transcription complex disruption caused by a transition in chromatin structure.

1991 • 95 citations

The thyroid hormone receptor functions as a ligand-operated developmental switch between proliferation and differentiation of erythroid progenitors

1998 • 94 citations

Influence of chromatin folding on transcription initiation and elongation by RNA polymerase III

1992 • 92 citations

The mechanism of nucleosome assembly onto oligomers of the sea urchin 5 S DNA positioning sequence

1991 • 91 citations

p300/CREB Binding Protein-Related Protein p270 Is a Component of Mammalian SWI/SNF Complexes

1998 • 90 citations

Nucleosome-mediated synergism between transcription factors on the mouse mammary tumor virus promoter

1997 • 88 citations

Nucleosome Assembly Activity and Intracellular Localization of Human CAF-1 Changes during the Cell Division Cycle

1998 • 88 citations

Structural and functional features of a specific nucleosome containing a recognition element for the thyroid hormone receptor

1997 • 87 citations

The amino-terminal tails of the core histones and the translational position of the TATA box determine TBP/TFIIA association with nucleosomal DNA

1995 • 84 citations

A role for histones H2A/H2B in chromatin folding and transcriptional repression.

1994 • 84 citations

A Conformational Switch in Nuclear Hormone Receptors Is Involved in Coupling Hormone Binding to Corepressor Release

1997 • 81 citations

The Affinity of Nuclear Factor 1 for Its DNA Site Is Drastically Reduced by Nucleosome Organization Irrespective of Its Rotational or Translational Position

1996 • 80 citations

Effects of Sin- versions of histone H4 on yeast chromatin structure and function

1997 • 79 citations

p300 stimulates transcription instigated by ligand-bound thyroid hormone receptor at a step subsequent to chromatin disruption

1999 • 78 citations

Structural features of a regulatory nucleosome

1990 • 77 citations

Histone acetylation in chicken erythrocytes. Rates of acetylation and evidence that histones in both active and potentially active chromatin are rapidly modified

1988 • 75 citations

Sin Mutations of Histone H3: Influence on Nucleosome Core Structure and Function

1997 • 74 citations

Nucleosomes associated with newly replicated DNA have an altered conformation

1978 • 69 citations

Architectural specificity in chromatin structure at the TATA box in vivo : Nucleosome displacement upon β-phaseolin gene activation

1998 • 68 citations

Role of Chromatin and Xenopus laevis Heat Shock Transcription Factor in Regulation of Transcription from the X. laevis hsp70 Promoter In Vivo

1995 • 64 citations

Hypothesis: RNA polymerase: Structural determinat of the chromatin loop and the chromosome

1994 • 58 citations

Effect of transcription of yeast chromatin on DNA topology in vivo.

1990 • 53 citations

TIF1α: A possible link between KRAB zinc finger proteins and nuclear receptors

1998 • 49 citations

Chromatin: the second wave. Chromatin structure and function (3rd edn) Academic Press, Cambridge, UK. 447 pp. Alan P. Wolffe.

2000 • 48 citations

Nucleosomal Location of the STE6 TATA Box and Matα2p-Mediated Repression

1994 • 45 citations

Amphibian Metamorphosis: A Complex Program of Gene Expression Changes Controlled by the Thyroid Hormone

1995 • 42 citations

Inhibition of Chromatin Assembly in Xenopus Oocytes Correlates with Derepression of the Mouse Mammary Tumor Virus Promoter

1991 • 42 citations

Organization of the Thyroid Hormone Receptor in Chromatin

1982 • 41 citations

Transcription Factor Access Is Mediated by Accurately Positioned Nucleosomes on the Mouse Mammary Tumor Virus Promoter

1991 • 41 citations

Histone hyperacetylation does not alter the positioning or stability of phased nucleosomes on the mouse mammary tumor virus long terminal repeat

1991 • 37 citations

Metamorphosis: an exquisite model for hormonal regulation of post-embryonic development.

1996 • 37 citations

Steroid Transactivation at a Promoter Organized in a Specifically-Positioned Array of Nucleosomes

1989 • 36 citations

Nucleosome-mediated disruption of transcription factor-chromatin initiation complexes at the mouse mammary tumor virus long terminal repeat in vivo

1994 • 33 citations

Assembly of nucleosomes: do multiple assembly factors mean multiple mechanisms?

1994 • 29 citations

Binding of Retinoic Acid Receptor Heterodimers to DNA

1998 • 27 citations

Asymmetric Linker Histone Association Directs the Asymmetric Rearrangement of Core Histone Interactions in a Positioned Nucleosome Containing a Thyroid Hormone Response Element

1998 • 27 citations

The Heat Shock Response in Xenopus Oocytes, Embryos, and Somatic Cells: A Regulatory Role for Chromatin

1995 • 27 citations

Inhibition of chromatin assembly in Xenopus oocytes correlates with derepression of the mouse mammary tumor virus promoter.

1991 • 24 citations

The hormone responsive region of mouse mammary tumor virus positions a nucleosome and precludes access of nuclear factor I to the promoter

1996 • 23 citations

Measurement of the linking number change in transcribing chromatin

1997 • 19 citations

Transcription Complex Disruption Caused by a Transition in Chromatin Structure

1991 • 15 citations

A Conformational Switch in Nuclear Hormone Receptors Is Involved in Coupling Hormone Binding to Corepressor Release

1998 • 4 citations